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    Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics
    Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics
    Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics
    Ebook238 pages1 hour

    Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics

    By Kedar Deodhar and Arun Chitale

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    About this ebook

    Histopathological evaluation is the gold standard in the diagnosis of malignant tumors and chronic diseases of visceral organs like liver, kidney and lungs. Histopathological analysis provides information that helps the clinician to choose the most appropriate treatment modality and assists in prognostication. Notwithstanding the current and future advances in the imaging technology and other innovations, the status of Histopathology will remain unchanged for decades to come.
    Whereas Histopathology is the most objective form of investigation, there are many gray areas in arriving at a definitive diagnosis. On many occasions total lack of clinical information leads to avoidable errors in the diagnosis. The surgical pathologist is advised to keep the cases pending until adequate information is available. On the other hand there are numerous problems in histological interpretation even if the entire clinical information is at hand. This occurs because some lesions have inherent morphological ambiguities and no two surgical pathologists may agree on the correct histological diagnosis. One such lesion, for example, is verrucous squamous cell carcinoma of the oro-pharyngeal region or other organs with squamous epithelial lining. The most controversial problem in thyroid disorders is a lesion called follicular variant of papillary carcinoma. In every organ and system, there are sporadic entities, which have debatable criteria of morphological diagnosis. The object of this book is to adequately address problems of uncommon morphologic variations of common lesions and rare difficult lesions with the help of extensive illustrations. There are excellent frequently updated textbooks of surgical pathology, in which all lesions occurring in various sites are described, illustrated and backed by references. However, due to constraints of space, these problematic entities are not extensively illustrated or explained at length. This deficiency is admirably handled in exclusively individual organ pathology monograms. However, this requires the facility of a well-stocked library; most practicing surgical pathologists do not have access to these.
    The proposed book is an attempt to address these lesions with multiple illustrations and detailed pertinent text. It is envisaged that the book should be a companion to a standard surgical pathology textbook and this should be accessible just at the fingertips via power of electronic media using internet. The targeted audience includes residents in Anatomic Pathology; young recently qualified pathologists and a large contingent of pathologists attached to medical institutions, in which the volume of surgical specimens is low.

    LanguageEnglish
    PublisherDhananjay Chitale
    Release dateMay 31, 2014
    ISBN9781311583758
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      Book preview

      Diagnostic Problems in Tumors of Female Genital Tract - Kedar Deodhar

      DIAGNOSTIC PROBLEMS IN TUMOR PATHOLOGY SERIES

      Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics

      Authors

      Kedar Deodhar, MD (Path), FRCpath

      Professor & Pathologist

      Tata Memorial Hospital, Mumbai, India

      Arun Chitale, MD (Path), DABP

      Diplomate American Board of Pathology (1969)

      Surgical Pathologist

      Sir HN Hospital, Jaslok Hospital, Surgical Pathology Center

      Formerly Professor & Head Department of Pathology Bombay Hospital Institute of Medical Sciences, Mumbai, India

      Published by Arun Chitale & Dhananjay Chitale at Smashwords

      Copyright 2014 Chitale publications

      Smashwords Edition, License Notes

      This ebook is licensed for your personal reading only. This ebook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each recipient. If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy. Thank you for respecting the hard work of the authors.

      Series Editors

      Arun Chitale, MD (Path), DABP

      Diplomate American Board of Pathology (1969)

      Surgical Pathologist

      Sir HN Hospital, Jaslok Hospital, Surgical Pathology Center

      Formerly Professor & Head Department of Pathology Bombay Hospital Institute of Medical Sciences, Mumbai, India

      Dhananjay Chitale, MD (Path), DNB, DABP

      Diplomate American Board of Pathology

      Director, Molecular Pathology & Genomic Medicine,

      Senior Staff Surgical Pathologist

      Director, Tissue Biorepostiroy

      Clinical Assistant Professor, Wayne State University School of Medicine

      Henry Ford Hospital, Detroit, Michigan, USA

      Diagnostic Problems in Tumors of Head and Neck: Selected Topics, 1/e

      Arun Chitale, Dhananjay Chitale, 2014

      Diagnostic Problems in Tumors of Gastrointestinal Tract Topics, 1/e

      Arun Chitale, Dhananjay Chitale, 2014

      Diagnostic Problems in Tumors of Female Genital Tract: Selected Topics, 1/e

      Kedar Deodhar, Arun Chitale, 2014

      Table of Content

      Endometrioid Adenocarcinoma of Endometrium & variants

      Cellular classification of Endometrial Carcinoma

      Endometrial Hyperplasia

      WHO Classification of Endometrial hyperplasia

      Endometrioid Adenocarcinoma with Squamous Differentiation

      Serous adenocarcinoma of endometrium

      Serous Endometrial Cancers (SC) That Mimic Endometrioid Carcinomas (EC)

      Endometrial Intraepithelial Carcinoma (EIC)

      Serous carcinoma arising in endometrial polyp

      Clear Cell Carcinoma of Endometrium (CCC)

      Endometrial Adenocarcinoma in Women under 40 years of Age

      Malignant Mixed Mullerian Tumors (MMMT)

      Mullerian Adenosarcoma (MA)

      Endometrial Stromal Tumor (EST)

      Low Grade Endometrial Stroma Sarcoma

      Endometrial Stromal Nodule

      Uterine smooth muscle tumors

      Leiomyosarcoma (LMS)

      Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP)

      Atypical leiomyoma

      Epithelioid Smooth Muscle Tumors

      Tumors of the uterine cervix

      Minimal Deviation Adenocarcinoma of Cervix

      Glandular Lesions of Cervix Mimicking Adenocarcinoma

      Deep cervical glands and cysts

      Tuboendometrioid Metaplasia (TEM) and Endometriosis

      Microglandular Adenosis (MGA) or hyperplasia

      Mesonephric remnants

      Endocervical Glandular Dysplasia

      Malignant Melanoma of Female Genital Tract

      Mucosal Melanoma

      Vulvar Melanoma

      Paget’s disease of Vulva

      Vaginal Melanoma

      Cervical Melanoma

      Sarcoma Botryoides (Embryonal Rhabdomyosarcoma)

      Gestational Trophoblastic diseases

      WHO Classification of Gestational Trophoblastic diseases

      Placental site trophoblastic tumor (PSTT)

      Exaggerated placental site reaction(synonymous with Syncitial endometritis)

      Placental Site Nodule/Plaque (PSN-P)

      Tumors of the Ovary

      Surface Epithelial Tumors

      Serous borderline tumors (SBT) Synonyms

      Serous borderline tumors with microinvasion

      ‘SBT with micropapillary pattern’ or is it micropapillary carcinoma?

      Serous borderline tumors with lymph node involvement

      Serous Carcinomas of Ovary

      Mucinous borderline tumors

      Mucinous Borderline Tumors

      MBT of intestinal type

      Intraepithelial carcinoma and microinvasion in intestinal MBT

      MBT: ovarian primary or metastatic mucinous carcinoma

      Pseudomyxoma Peritonei (PMP)

      Clear cell carcinoma of the ovary

      Gonadoblastoma (Germ cell-sex cord-stromal tumor)

      Metastatic Tumors in ovaries (Krukenberg tumors)

      Distinction between Primary and Metastatic Mucinous Carcinomas of the Ovary

      Aggressive Angiomyxoma (AAM)

      PEComa of the Female Genital Tract

      Fallopian Tube Serous Carcinoma &Molecular Pathogenesis of Ovarian Carcinoma

      References

      PREFACE:

      DIAGNOSTIC PROBLEMS IN SURGICAL PATHOLOGY:

      Uncommon presentation of common lesions and rare lesions

      Histopathological evaluation is the gold standard in the diagnosis of malignant tumors and chronic diseases of visceral organs like liver, kidney and lungs. Histopathological analysis provides information that helps the clinician to choose the most appropriate treatment modality and assists in prognostication. Notwithstanding the current and future advances in the imaging technology and other innovations, the status of Histopathology will remain unchanged for decades to come.

      Whereas Histopathology is the most objective form of investigation, there are many gray areas in arriving at a definitive diagnosis. On many occasions total lack of clinical information leads to avoidable errors in the diagnosis. The surgical pathologist is advised to keep the cases pending until adequate information is available. On the other hand there are numerous problems in histological interpretation even if the entire clinical information is at hand. This occurs because some lesions have inherent morphological ambiguities and no two surgical pathologists may agree on the correct histological diagnosis. One such lesion, for example, is verrucous squamous cell carcinoma of the oro-pharyngeal region or other organs with squamous epithelial lining. The most controversial problem in thyroid disorders is a lesion called follicular variant of papillary carcinoma. In every organ and system, there are sporadic entities, which have debatable criteria of morphological diagnosis. The object of this book is to adequately address problems of uncommon morphologic variations of common lesions and rare difficult lesions with the help of extensive illustrations. There are excellent frequently updated textbooks of surgical pathology, in which all lesions occurring in various sites are described, illustrated and backed by references. However, due to constraints of space, these problematic entities are not extensively illustrated or explained at length. This deficiency is admirably handled in exclusively individual organ pathology monograms. However, this requires the facility of a well-stocked library; most practicing surgical pathologists do not have access to these.

      The proposed book is an attempt to address these lesions with multiple illustrations and detailed pertinent text. It is envisaged that the book should be a companion to a standard surgical pathology textbook and this should be accessible just at the fingertips via power of electronic media using internet. The targeted audience includes residents in Anatomic Pathology; young recently qualified pathologists and a large contingent of pathologists attached to medical institutions, in which the volume of surgical specimens is low.

      Note on statistical data presented in this eBook:

      The senior author (ARC) has been a practicing consultant surgical pathologist for the last 44 years (1969-2013). As a surgical pathologist, he has been associated with ‘surgical pathology center’ (his own lab). He is also attached to the following hospitals in Mumbai (Bombay): Sir H N Hospital, Bombay Hospital and Jaslok Hospital (all corporate institutions), Bone Registry, Grant Medical College; Cytology department of KEM Hospital.

      He has gathered vast amount of neoplastic cases of different organ-systems and the data has been in the form of Tables for different organ systems. The statistical tabulation of tumors has been based on classification of anatomical site and behavior (benign or malignant). This is not purported to be a population based epidemiological data. However, the data likely represents a fair cross sectional distribution and representation of various neoplasms in the population served in Metropolitan Mumbai (Bombay), India.

      DISCLAIMER:

      This Book titled Diagnostic Problems in tumors of Female Genital tract: selected topics, is made available by the Authors solely for trained and licensed physician for personal, non-commercial teaching and educational use. No two individual patients with neoplasms are identical and therefore diagnosis and treatment varies greatly depending on the medical and surgical history. The information contained in this Book is not medical advice. It is the professional responsibility of the practitioner to apply the information provided in a specific situation. Attention has been taken for accuracy of the information presented to describe generally accepted practices; however, knowledge and best practice in the field constantly change with new research. Readers are advised to check the most current information. The authors, editors and publishers are not responsible for errors or omissions or for

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