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Mucosal Vaccines
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Mucosal Vaccines
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Mucosal Vaccines
Ebook1,587 pages18 hours

Mucosal Vaccines

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About this ebook

This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology.
  • Provides the latest views on mucosal vaccines
  • Applies basic principles to the development of new vaccines
  • Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases
  • Unique and user-friendly organization
LanguageEnglish
Release dateOct 23, 1996
ISBN9780080537054
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Mucosal Vaccines
Author

Hiroshi Kiyono

University of Alabama, Birmingham, U.S.A. and Osaka University, Japan Since the 1970s, Professor Kiyono has been investigating and characterizing unique features of the mucosal immune system to establish mucosal immunology as an area of the immunology field as well as to develop effective and safe mucosal vaccines against infectious diseases and mucosal immune therapies against allergic and inflammatory diseases. He recently developed cold-chain- and needle-free rice-based vaccines (MucoRice) with the cooperation of agricultural researchers. The vaccine antigens exogenously expressed in MucoRice are temperature-stable for at least 2.5 years and are resistant to digestive enzymes, thus they effectively induce vaccine antigen-specific protective immunity in both systemic and mucosal compartments against toxins produced by pathogenic microorganisms (e.g., cholera toxins). Additionally, his efforts aim to clarify the immunological cross-talk between the mucosal immune system and mucosal environmental factors (e.g., commensal bacteria and dietary materials) in immunological homeostasis. These studies will lead to the development of novel immune therapies against mucosal immune diseases, such as food allergy, rhinitis, and inflammatory bowel diseases.

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