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    Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
    Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
    Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets
    Ebook63 pages33 minutes

    Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets

    By Dr. Pharm Tao

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    About this ebook

    Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available. The pandemic of the deadly COVID-19 is a reminder that such coronaviruses can emerge at any time. Novel human coronaviruses (HCoVs) may lead to Acute Respiratory Distress Syndrome (ARDS) and renal failure. They are highly transmissible and can spread from person-to-person through close contact. Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic. Experiences from SARS and MERS outbreaks have revealed the demands for drugs with pan-coronavirus antiviral activities. The potential antiviral agents include neutralizing antibodies and drugs targeting the coronaviral envelope protein. Vaccine platforms can be used to transport antigens and immunostimulatory cytokines to enable protective immunity. Some compounds have been found to inhibit the replication of SARS and Ebola viruses. These compounds may be useful for the development of broad-spectrum drugs against viruses. Medicinal herbs and extracts have potential anti-CoV effects. The herbal extracts may inhibit viral replication and suppress SARS-CoV protease activity. The antiviral effects of regular household products have been evaluated against SARS-CoV. Studies of SARS-CoV have focused on the accessory proteins, host cell entry, nucleocapsid protein, spike protein, and viral proteases. The SARS-CoV and MERS-CoV have altered signaling pathways for evading early innate immune responses. Understanding of these mechanisms is critical for finding drugs for the treatment of COVID-19, SARS, MERS, and other coronavirus diseases.

    LanguageEnglish
    PublisherDr. Pharm Tao
    Release dateJul 31, 2020
    ISBN9781005839895
    Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets

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      Book preview

      Potential Antiviral Agents for Coronaviruses - Dr. Pharm Tao

      Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets

      Potential Antiviral Agents for Coronaviruses: Compounds, Herbal Products, and Drug Targets

      Pharm Tao

      2020

      ISBN 9781005839895

      Copyright © 2020 by Pharm Tao

      All rights reserved. No parts of this publication may be reproduced or utilized, stored in a retrieval system, or transmitted, in any form or by any means, electronic or mechanical, including photocopying, recording, or otherwise, without prior written permission from the copyright owner.

      The information in this publication is true and complete to the best of our knowledge. The author disclaims any liability in connection with the use of this information. The information provided is not intended for diagnosis, or to treat, cure or prevent any diseases, conditions or symptoms, or to endorse any products. Personal directions and use of drugs and herbs should be provided by qualified health professionals.

      Publisher’s Website: www.pharmtao.com

      Contents

      Preface 5

      Chapter 1: Potential Broad-Spectrum Antiviral Drugs 6

      Chapter 2: Potential Antiviral Compounds 13

      Chapter 3: Antiviral Herbal Extracts for Coronaviruses 17

      Chapter 4: Potential Antivirals for SARS-CoV 29

      Chapter 5: Drug Targets for Coronaviruses 38

      Preface

      Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available.

      The pandemic of the deadly COVID-19 is a reminder that such coronaviruses can emerge at any time.

      Novel human coronaviruses (HCoVs) may lead to Acute Respiratory Distress Syndrome (ARDS) and renal failure.

      They are highly transmissible and can spread from person-to-person through close contact.

      Broad-spectrum antiviral drugs may lower the vulnerability of public health systems to the coronavirus pandemic.

      Experiences from SARS and MERS outbreaks have revealed the demands for drugs with pan-coronavirus antiviral activities.

      The potential antiviral agents include neutralizing antibodies and drugs targeting the coronaviral envelope protein.

      Vaccine platforms can be used to transport antigens and immunostimulatory cytokines to enable protective immunity.

      Some compounds have been found to inhibit the replication of SARS and Ebola viruses.

      These compounds may be useful for the development of broad-spectrum drugs against viruses.

      Medicinal herbs and extracts have potential anti-CoV effects.

      The herbal extracts may inhibit viral replication and suppress SARS-CoV protease activity.

      The antiviral effects of regular household products have been evaluated against SARS-CoV.

      Studies of SARS-CoV have focused on the accessory proteins, host cell entry, nucleocapsid protein, spike protein, and viral proteases.

      The SARS-CoV and MERS-CoV have altered signaling pathways for evading early innate immune responses.

      Understanding of these mechanisms is critical for finding drugs for COVID-19, SARS, MERS, and other coronavirus diseases.

      Chapter 1: Potential Broad-Spectrum Antiviral Drugs

      Coronaviruses (CoVs)

      Coronaviruses (CoVs) may lead to lethal infections, but currently no effective antiviral therapeutics or vaccines are available.

      The pandemic of the deadly coronavirus

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