1

30 21

30 21

Purines
Adenine = 6-amino purine Guanine = 2-amino-6-oxy purine

Hypoxanthine = 6-oxy purine

Xanthine = 2,6-dioxy purine

12 30

Pyrimidines
Uracil = 2,4-dioxy pyrimidine Thymine = 2,4-dioxy5-methyl pyrimidine Cytosine = 2-oxy-4amino pyrimidine Orotic acid = 2,4dioxy-6-carboxy pyrimidine
4 12 30

Medical relevance of nucleotide pathways

Critical in cancer treatment Hydroxyurea, anti-folates, FdUMP, 5-FU, etc Antiviral therapies

acyclovir and herpes

Important inborn errors and pathologies Adenosine deaminase and SCIDS Lesch-Nyhan Syndrome Hyperuricemia
5 12 30

30 21

30 21

30 21

30 21

01

30 21

11

30 21

21

30 21

31

30 21

41

30 21

51

30 21

61

30 21

71

30 21

81

30 21

91

30 21

Orotic aciduria
an inherited human disease caused by a deficiency in the multifunctional enzyme that catalyzes the last 2 steps in the pyrimidine synthesis large amounts of orotic acid in urine retarded growth and severe anemia treat by administration (injection) of uridine and/or cytidine
20 12 30

12

30 21

22

30 21

32

30 21

42

30 21

52

30 21

TETRAHYDROFOLATE

26

12 30

72

30 21

82

30 21

92

30 21

03

30 21

Severe combined immunodeficiency (SCID), or Bubble Boy Syndrome

31

12 30