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INTRODUCTION
Sialolithiasis refers to non-cancerous stones (calcium-rich crystallized minerals known as salivary calculi or sialoliths) in a salivary gland or duct. Sialolithiasis accounts for more than 50% of diseases of the large salivary glands and is thus the most common cause of acute and chronic infections.
More than 80% occur in the submandibular gland or its duct 6% in the parotid gland 2% in the sublingual gland or minor salivary glands Most salivary stones are single; however multiple stones may be present.
There are three pairs of major salivary glands: (i) the parotid glands, (ii) the sublingual glands, (iii) the submandibular glands. In addition to these major glands, there are hundreds of minor salivary glands that are scattered throughout the mouth and throat.
DUCTS
Parotid duct
located by maxillary bone 2nd upper molar) Stensens duct PAROTID GLAND
SUBLINGUAL GLAND
Sialolithiasis
Sialolithiasis results in a mechanical obstuction of the salivary duct Is the major cause of unilateral diffuse parotid or submandibular gland swelling2
Sialolithiasis Incidence
It is estimated that it affects 12 in 1000 of the adult population. Escudier & McGurk 1:15-20 000 Marchal & Dulgurerov 1:10-20 000 Males are affected twice as much as females Sialolithiasis remains the most frequent reason for submandibular gland resection
Sialolithiasis
The exact pathogenesis of sialolithiasis remains unknown. Thought to form via.
an initial organic nidus that progressively grows by deposition of layers of inorganic and organic substances.
Salivary stagnation Epithelial injury along the duct resulting in sialolith formation, which acts as a nidus for further stone formation Precipitation of calcium salts
Pathogenesis ...........
Traditional theories suggest that the formation occurs in two phases: a central core and a layered periphery. The central core is formed by the precipitation of salts, which are bound by certain organic substances. The second phase consists of the layered deposition of organic and non organic material. Submandibular stones are thought to form around a nidus of mucous, parotid stones are thought to form most often around a nidus of inflammatory cells or a foreign body.
Pathogenesis ...........
Another theory has proposed that an unknown metabolic phenomenon can increase the saliva bicarbonate content, which alters calcium phosphate solubility and leads to precipitation of calcium and phosphate ions.
Pathogenesis ...........
A retrograde theory for sialolithiasis has also been proposed. Aliments, substances or bacteria within the oral cavity might migrate into the salivary ducts and become the nidus for further calcification
Sialolithiasis
May eventually obstruct flow of saliva from the gland to the oral cavity. Acute ductal obstruction may occur at meal time when saliva producing is at its maximum, the resultant swelling is sudden and can be painful.
Sialolithiasis
Gradually reduction of the swelling can result but it recurs repeatedly when flow is stimulated. This process may continue until complete obstruction and/or infection occurs.
Etiology
Water hardness likelihood? Maybe. Hypercalcemiain rats only Xerostomic medicines - anti-histamines, antihypertensives and anti-psychotics Tobacco smoking, positive correlation Smoking has an increased cytotoxic effect on saliva, decreases PMN phagocytic ability and reduces salivary proteins
Etiology
Gout is the only systemic disease known to cause salivary calculi and these are composed of uric acid.
Stone Composition
Organic; often predominate in the center
Glycoproteins Mucopolysaccarides Bacteria! Cellular debris
Other characteristics:
Despite a similar chemical make-up, 80-90% of SMG calculi are radio-opaque 50-80% of parotid calculi are radiolucent 30% of SMG stones are multiple 60% of Parotid stones are multiple
Other characteristics:
Submandibular stones are 82% inorganic and 18% organic material parotid stones are composed of 49% inorganic and 51% organic material
Clinical presentation
Painful swelling (60%) Painless swelling (30%) Pain only (12%)
Sometimes described as recurrent salivary colic and spasmodic pains upon eating
Clinical History
History of swellings / change over time? Trismus? Pain? Variation with meals? Bilateral? Dry mouth? Dry eyes? Recent exposure to sick contacts (mumps)? Radiation history? Current medications?
Exam: Inspection
Asymmetry (glands, face, neck) Diffuse or focal enlargement Erythema extra-orally Trismus Medial displacement of structures intraorally? Examine external auditory canal (EAC) Cranial nerve testing
Exam: Palpation
Palpate for cervical lymphadenopathy Bimanual palpation of floor of mouth in a posterior to anterior direction
Have patient close mouth slightly & relax oral musculature to aid in detection Examine for duct purulence
Diagnostic approaches
CT Scan: large stones or small CT slices done also used for inflammatory disorders Ultrasound: operator dependent, can detect small stones (>2mm), inexpensive, non-invasive Although US has proven value, sialoliths smaller than 23 mm may be overlooked because an acoustic shadow may be absent
Sialography continued
Disadvantages:
irradiation dose pain with procedure Possible perforation infection dye reaction push stone further contraindicated in active infection.
Sialography continued
Digital sialography and digital subtraction sialography are the favored techniques for help in the detection of sialolithiasis of the submandibular duct. Even nonradiopaque sialoliths are detectable with this technique.
Sialography continued
Another advantage of digital sialography and digital subtraction sialography is the ability to make small adjustments in the positioning of the patients head during imaging, thus ensuring more accurate positioning and collimation. Motion artifacts, however, are a severe problem with digital subtraction sialographic images
Sialolithiasis Treatment
None: antibiotics and anti-inflammatories, hoping for spontaneous stone passage. Stone excision:
Lithotripsy Interventional sialendoscopy Simple removal (20% recurrence)
Gland excision
Sialolithiasis Treatment
If patients DO defer treatment, they need to know: Stones will likely enlarge over time Seek treatment early if infection develops Salivary gland massage and hyper-hydration when symptoms develop.
Stone excision
External lithotripsy
Stones are fragmented and expected to pass spontaneously The remaining stone may be the ideal nidus for recurrence
Interventional Sialendoscopy
Can retrieve stones, may also use laser to fragment stones and retrieve.
Posterior Stones
Deeper submandibular stones (~15-20% of stones) may best be removed via sialadenectomy. Some surgeons say can still remove transorally, but should be done via general anesthetic. Floor of mouth (FOM) opened opposite the first premolar, duct dissected out, lingual nerve identified. Duct opened & stone removed, FOM approximated.
Gland excision
After SMG excision, 3% cases have recurrence via:
Retention of stones in intraductal portion or new formation in residual Wharton's duct
Future !!
Alpha-blocker........ Guerre and associates (2010) evaluated the safety and effectiveness of alfuzosin, an alpha-blocker, in patients with ductal stenosis, allergic pseudoparotitis or sialolithiasis after lithotripsy Still experimental and investigational for the treatment of sialolithiasis because their effectiveness for this indication has not been established.