Errata | Pathoma

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Page Section 13 IV.E.1

Line phagocytosis is enhanced by opsonins (IgG and C3a) Symptoms of skin bleeding include petechiae, ecchymoses (> 3mm), purpura (> 1 cm) Aminolevulinic acid dehydrogenase (ALAD) converts ALA to porphobilinogen

Comment CORRECTION C3b (and not C3a) is the opsonin. Should read (IgG and C3b) CORRECTION Ecchymoses are >1cm and purpura are > 3mm. Should read include petechiae, purpura (>3mm), and ecchymoses (>1cm) TYPO The enzyme is ALA dehydratase (not dehydrogenase). CLARIFICATION More recent studies show that hemolysis occurs throughout the day. Hence, the color change (hemoglobinemia) seen in the first void upon

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II. B. 2.

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IV. B. 2.

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I. B

Intravascular hemolysis occurs episodically, often at night during sleep

awakening is mostly due to urine production and concentration of hemoglobin overnight (as opposed to hemolysis occurring mostly at night). Of note, my explanation in the text remains partly true and is an excellent way to remember the pathophysiology of this disorder. CLARIFICATION Nitrates do result in coronary artery vasodilation. However, a more significant effect is 06/21/2011

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G. 3.

Nitrates vasodilate coronary arteries

vasodilation of veins. This results in decreased venous return to the heart, which in turn, decreases preload and, hence, stress on the myocardium.

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Table 9.5, Squamous 96 cell carcinoma (under characteristic histology) CORRECTION The gastroduodenal artery lies posterior May rupture leading to bleeding from the 105 VI. B. 3. gastroduodenal artery (anterior ulcer) or acute pancreatitis (posterior ulcer) to the duodenum. Hence, rupture of a posterior (and not anterior) ulcer would lead to bleeding from the GDA. Should read gastroduodenal artery (posterior ulcer) or acute pancreatitis (posterior ulcer). CLARIFICATION Tram-track appearance can be seen 128 V. A. Thick glomerular basement membranes on H&E, often with tram-track appearance in both type I and type II MPGN. However, it is more commonly seen with type I (USMLE examiners do ask about this!). CORRECTION The crystals in gout exhibit negative 199 Fig. 18.9 Gout. A, Tophi. B, Postive birefringence. birefringence (and not, positive birefringence). This is correct in the text, but needs to be corrected in the image caption. 06/21/2011 06/21/2011 06/21/2011 Kertain pearls or intracellular bridges TYPO intracellular should read intercellular 06/21/2011

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