Supplement Treatment for Rheumatoid Arthritis Asuka Suzuki

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Omega 6 fatty acid and Omega 3 fatty acid

Omega-6 fatty acids play a role in of many of our Western diseases, including cardiovascular disease, cancer, inflammatory and autoimmune disease.

Whereas Omega 6 fatty acid induces inflammation, Omega 3 fatty acid induces anti inflammation.

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Omega-6 fatty acid

Omega-6 fatty acid
Corticosteroids Linoleic acid , Bromelain (Pineapple), Feverfew, Licorice, Camomile, Curcumin Adrenal Gland - linoleic acid (GLA) Daily, Beef, Pork 2 -homo- - linolenic acid Prostaglandin-1 (anti inflammatory PG) Prostaglandin-2 (inflammatory PG) Thromboxane (inducing inflammation)

Arachidonic acid
Onion, Garlic, Curcumin, Quercetin Zingiber (ginger)

Leukotriene (inducing inflammation)

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Omega-3 fatty acid

Omega-3 fatty acid
linolenic acid (ex. Flaxseeds with Vitamin E or Selenium) -6 desaturated enzyme Vitamin B6, Mg, Zinc Suteadorin acid (ex. Black currant oil) -5 desaturated enzyme Vitamin C, Niacin, Zinc EPA (eicosapentaenoic acid) (ex. Sardine, Salmon, Mackerel,
Cod especially Cod liver oil )

Prostaglandin-3 (anti inflammation PG)

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Contentained amount of EFA

Oil
Omega-3 fatty acid Omega-6 fatty acid

Flaxseed Salmon Nut Soybean Safflower Sunflower Almond Olive Coconut

60 30 10 8 1 1 1 1 1

20 20 40 50 58~75 20~72 14~44 8~15 2~3

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Lactoferrin An iron-binding protein that is released from activated neutrophils at sites of inflammation and has anti-microbial as well as anti-inflammatory properties.

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Folic acid
Folic acid supplementation limit the toxicity of methotrexate on blood cells, gastrointestinal tract and liver.

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

Study
Paul Sabatier University and Purpan Hospital Total sample of 648 patients. There were 257 patients in the placebo group, 198 patients treated with folic acid, and 193 patients treated with folinic acid. a significant reduction of 35.8% of hepatic side-effects induced by methotrexate for patients with supplementation with folic or folinic acid.

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)

However,
Dr. Alberto Sulli, Genoa University, Italy advocated folic acid decreasing not only side effect of MTX but also beneficial effect.

You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com)