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Hypertension
30
25
Percent of cases
20
15
10
Down Syndrome
General Population
Patients with high cholesterol, high incidence of diabetes and obesity Minimal Hypertension Autopsy studies showing minimal coronary plaque Lancet Study: Incidence of ischemic heart disease %7
Increased incidence of leukemia (RR 10-18) Overall mortality from leukemia (RR 1.5-3) 92% of cases are diagnosed before age 20 Leukemia accounts for more than 50% of all cancers in patients with Down Syndrome
Cancer Type Testicular Colorectal Breast Lung Prostate Cervical Leukemia Non-Leukemia Malignancy
Standardized mortality odds ratio 3.23 0.08 0.04 0.02 0.08 0.00 1.57 0.07
o o o o
Increased pain tolerance Behavior as sign of underlying disease Self talking Visual Memory
Identification of genetic protection from cancer Understanding of Vascular Physiology Implication of benefits for adults with Down Syndrome