Patofisiologi Graves Diseases

1. Jantung Thyroid () -adrenergic reseptor () myosin di myocardium() Transkripsi CaATPase di sarcoplasma reticulum () Heart rate () CO () 2. Metabolisme. Thyroid () Lipolisis () Glukoneogenesis () Gula darah () LDL receptor di hepar () Degradasi kolesterol () Total kolesterol () 3. Heat production. BMR naik Produksi panas naik 4. Paru-paru. Thyroid () respon ventilatory di brain stem, respiration rate meningkat. Palmar moist Mudah lelah Palpitasi Tekanan.systole () Relaksasi myocardium () Tekanan.diastole ()

5. Gastro intestinal effect. Motility bowel () Absorpsi makanan kurang BB () 6. Neuromuscular effect. Thyroid () Produksi norepineprine () Respon terhadap katekolamin () Mudah lelah

Fine tremor and hyperreflexia 7. Leher dan kepala. Antigen di kelenjar thyroid T lymphocite jadi sensitif Respon inflamasi di orbital Inflamasi fibroblast & orbital muscle Swelling anterior neck. Vaskular bruit Vaskularisasi () B limphocite menghasilkan antibodi Stimulasi growth and function of thyroid