Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia

ANTIGEN

SUBSTANCE BIOLOGIC MOLECULES (SUGAR, LIPID, HORMON) MACROMOLECULES (PROTEIN, POLYSACCHARIDE, PHOSPHOLIPID) THAT SPECIFICALLY BOUND BY

ANTIBODY T CELL RECEPTOR

IMMUNOGEN SUBSTANCE (MACROMOLECULES) THAT STIMULATE B CELLS

TO PRODUCE

SPECIFIC ANTIBODY

SMALL MOLECULES HAPTEN

BOUND TO

MACROMOLECULES CARRIER

IMMUNOGEN

ANTIBODY

SPECIFIC GLYCOPROTEIN REFERRED TO AS IMMUNOGLOBULIN (GAMMA GLOBULIN)

COMBINE WITH ANTIGEN COMPLEMENT

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

IgM Ig POOL MW HALF LIFE H CHAIN SUBCLASS SECRETED FORM FUNCTION 10 % 900.000 5 days

IgG 70-75% 160.000 23 days

NONE PENTAMER NAIVE B CELL ANTIGEN RECEPTOR C ACTIVATION

4 MONOMER OPSONIZATION C ACTIVATION ADCC

IgA Ig POOL MW HALF LIFE H CHAIN SUBCLASS SECRETED FORM FUNCTION 15-20% 360.000 6 days

IgE

IgD 1% 160.000 3 days

200.000 2 days

2 MONOMER DIMER MUCOSSAL IMMUNITY

NONE MONOMER

NONE NONE

IMMEDIATE HYPERSENSITIVITY ADCC (EOSINOPHIL) DEFENCE AGAINST HELMINTHIC PARASITE

NAIVE B CELL ANTIGEN RECEPTOR

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

MHC GENE PRODUCT MHC MOLECULE HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS I CLASS II MEMBRANE GLYCOPROTEIN

CLASS I POLYPETIDE CHAIN PEPTIDE BINDING SIZE OF PEPTIDE BINDING DISTRIBUTION 1, 2, 3 chain 2 MICROGLOBULIN 1 and 2 8 11 RESIDUE NUCLEATED CELLS

CLASS II 1, 2 chain 1, 2 chain 1 and 1 10 30 RESIDUE DENDRITIC CELLS B CELLS MACROPHAGE HLA - DR, DQ, DP PRESENTED PROCESSED Ag TO T CYTOTOXIC (CD8)

NOMENCLATURE FUNCTION

HLA - A, B, C PRESENTED PROCESSED Ag TO T HELPER (CD4)

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

CELLS
ANTIGEN MITOGEN

CYTOKINE LYMPHOKINE MONOKINE INTERLEUKIN

MEDIATE & REGULATE

IMMUNE & INFLAMMATORY REACTION

SOURCE

REC CELLS

AUTOCRINE ENDO CRINE

BIOLOGIC EFFECTS

ACTION

CYTOKINE

PARACRINE
REC CELLS
TARGET

PROPERTIES OF CYTOKINE

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ANTIGEN IMMUNE SYSTEM PRIMARY LYMPHOID THYMUS BONE MARROW SECONDARY LYMPHOID LYMPH NODES SPLEEN MALT (Mucosa Associated Lymphoid Tissues)

IMMUNE RESPONSE

IMMUNE RESPONSE

INNATE IMMUNITY

ADAPTIVE IMMUNITY

HOST DEFENSE TISSUE INJURY & DISEASE

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

INNATE IMMUNITY

CELLULAR PHAGOCYTES (PMN & MN) NK CELLS

HUMORAL COMPLEMENT CYTOKINES

PHAGOCYTOSIS INFLAMMATION

PHAGOCYTOSIS

RECRUITMENT OF LEUCOCYTES TO SITES OF INFECTION

RECOGNITION OF MICROBES BY PHAGOCYTES

PHAGOCYTOSIS AND INTRACELLULAR KILLING OF MICROBES

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

TOLL LIKE Pattern recognition receptor = PRR RECEPTOR

PHAGOCYTE

Pathogen-associated molecular pattern = PAMP

LPS

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

VIRUS

MICROBES

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ADAPTIVE IMMUNITY

CELLULAR T CELLS B CELLS

CELL MEDIATED IMMUNITY (CMI)

HUMORAL ANTIBODIES CYTOKINES

T CELL
RECOGNIZE
PROCESSED Ag

TCR

NOT RECOGNIZE
NATIVE Ag

MHC MOL

APC

PROCESSING PRESENTING

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY

ABBAS AK, LICHTMAN AH: CELLULAR AND MOLECULAR IMMUNOLOGY