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Abstract Malignant melanoma is among the malignant tumors whose incidence has risen markedly in recent decades.

For many years the medical community debated the potential adverse effects of female hormones (whether of exogenous or pregnancy-related endogenous origin), on melanocytic nevi and malignant melanoma. iven that women have been delaying pregnancy until their thirties or forties and that the incidence of malignant melanoma increases in those decades, the likelihood of this tumor developing during pregnancy has increased. !ecent clinical and experimental evidence has suggested that pregnancy does not affect prognosis in malignant melanoma and that it does not seem to lead to significant changes in nevi. "his review examines the relationship between malignant melanoma and hormonal and reproductive factors. #vidence was located by M#$%&'# search (in (ubMed and )vid) for articles in #nglish and *panish for the period from +,-- to March ./+/0 additional sources were found through the reference lists of the identified articles. 1 ./+/ #lsevier #spa2a, *.%. and 3#$4. 3ll rights reserved.

PALABRAS CLAVE
Melanoma0 #mbara5o0 'evus melanoc6ticos0 7ormonas0 Factores reproductivos Nevus, melanoma y embarazo
Resumen #l melanoma maligno (MM) es uno de los tumores malignos 8ue m9s ha aumentado su incidencia en las :ltimas d;cadas. $urante muchos a<nos hubo controversia en la comunidad m;dica en relaci=n con el efecto potencialmente adverso de las hormonas femeninas (ex=genas o end=genas asociadas al embara5o) sobre los nevus melanoc6ticos y el MM. >onsiderando 8ue las mu?eres han retrasado la maternidad hasta la tercera y cuarta d;cadas de la vida, y 8ue la incidencia de MM aumenta en estas d;cadas, la probabilidad de aparici=n de un MM durante el embara5o es mayor. #videncias cl6nicas y experimentales recientes permiten sugerir 8ue el embara5o no influye en el pron=stico del MM, y 8ue no parece causar cambios significativos en los nevus. %a finalidad de este art6culo es revisar la asociaci=n entre MM, nevus y factores hormonales y reproductivos.
(lease cite this article as@ Aorges 4, et al. 'evus, melanoma y embara5o. 3ctas $ermosifiliograr. ./++0+/.@-B/--BC. >orresponding author. E-mail address: valborgesDhotmail.com (4. Aorges). +BCE-.+,/FG
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