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  • Pityriasis Rosea Patogenesis

    Încărcat de

    Adrian Kuswanto
    125 vizualizări4 pagini
    This document summarizes the pathogenesis, pathophysiology, and clinical symptoms of pityriasis rosea. It notes that the condition is caused by a viral infection which leads to an initial herald patch and primary rash of solitary lesions along skin lines. It involves increased CD4 T cells and Langerhans cells, as well as a lack of NK and B cells. Symptoms include a prodromal illness, herald patch, primary eruption of lesions, and secondary eruption involving keratinocytes, mast cells, T cells, and eosinophils which cause itching and infection through the release of substances like nerve growth factor.

    Descriere originală:

    Pityriasis Rosea

    Titlu original

    Patogenesis Patofisiologi Gejala Klinik

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    © Attribution Non-Commercial (BY-NC)

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    This document summarizes the pathogenesis, pathophysiology, and clinical symptoms of pityriasis rosea. It notes that the condition is caused by a viral infection which leads to an initial herald patch and primary rash of solitary lesions along skin lines. It involves increased CD4 T cells and Langerhans cells, as well as a lack of NK and B cells. Symptoms include a prodromal illness, herald patch, primary eruption of lesions, and secondary eruption involving keratinocytes, mast cells, T cells, and eosinophils which cause itching and infection through the release of substances like nerve growth factor.

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca PPTX, PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    125 vizualizări4 pagini

    Pityriasis Rosea Patogenesis

    Încărcat de

    Adrian Kuswanto
    This document summarizes the pathogenesis, pathophysiology, and clinical symptoms of pityriasis rosea. It notes that the condition is caused by a viral infection which leads to an initial herald patch and primary rash of solitary lesions along skin lines. It involves increased CD4 T cells and Langerhans cells, as well as a lack of NK and B cells. Symptoms include a prodromal illness, herald patch, primary eruption of lesions, and secondary eruption involving keratinocytes, mast cells, T cells, and eosinophils which cause itching and infection through the release of substances like nerve growth factor.

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca PPTX, PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    din 4

    Adrian Kuswanto - 1110005

    Pityriasis Rosea Patogenesis Patofisiologi Gejala Klinik

    Patogenesis-Patofisiologi-Gejala Klinik
    Viral infection
    Viral antigen preocessing & presentation Prodromal illness (Upper Respiratory Infection) Herarld Patch Primary eruption (Solitary)

    A lack of natural killer (NK) cell and B-cell activity. Increased amounts of CD4 T cells and Langerhans cells. IgM to keratinocytes Secondary eruption

    Lesions aligning along Langer's lines

    Disorders

    Keratinocytes, mast cell, T cell, eosinofil (epidermis & dermis)

    Nerve Growth Factor, Subs. P, IL-31, histamine, Neurotrophin 3-4

    Dorsal Root Ganglia Spinal Cord Central Nerve System

    Antiseptic

    Triclosan

    Flora normal berkurang Kering gatal Infeksi Sekunder

    Berjemur

    Penguapan meningkat

    http://www.aafp.org/ http://emedicine.medscape.com/article/110 7532-overview

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