Documente Academic
Documente Profesional
Documente Cultură
Submitted to
Prof. N.K.Jain
Submitted by
Surbhi Dubey
Saket Asati
Amit Verma
Object: To prepare and evaluate Ibuprofen matrix tablets and observes the
effect of different polymer (Methyl cellulose, Hydroxy propyl methyl cellulose
and Ethyl cellulose) on drug release profile.
1. Hardness Testing:
Tablet
1st
2nd
5.5
3rd
Avera
ge
MC
Avera
ge
EC
5.5
3.5
5.16
Average
5.5
3.16
5.66
2. Friability Testing:
S.
No
.
Before
HPM
MC
After
EC
HPM
MC
EC
HPM
Avg
6.10
6.20
6.23
6.06
6.17
6.18
0.65
6.33
6.34
6.18
6.28
6.29
6.14
0.78
MC
Av
g.
0.48
0.74
0.78
vg.
0.8
0.6
0.64
6.15
6.25
6.30
6.10
6.20
6.26
0.81
0.8
0.63
0.69
Individual Weight
Polymer
HPMC
MC
0.53
0.56
0.54
0.55
0.56
-1.81
1.81
0.55
0.57
0.54
3.63
-1.81
0.56
0.55
0.55
1.81
0.55
0.54
0.54
-1.81
-1.81
0.53
0.53
0.58
-3.63
-3.63
-5.4
0.58
0.55
0.55
5.4
0.55
0.56
0.57
1.81
3.63
0.57
0.57
0.56
3.63
3.63
1.81
10
0.54
0.56
0.55
-1.81
1.81
11
0.55
0.58
0.54
5.4
-1.81
12
0.56
0.55
0.52
1.81
-5.4
13
0.57
0.54
0.55
3.63
-1.81
14
0.56
0.56
0.54
1.81
1.81
-1.81
15
0.57
0.56
0.56
3.63
1.81
-1.81
16
0.55
0.54
0.55
-1.81
17
0.55
0.55
0.57
3.63
18
0.56
0.57
0.56
1.81
3.63
1.81
19
0.54
0.55
0.55
-1.81
20
0.53
0.56
0.55
-3.63
1.81
n=1
n=2
Time
(Min)
mcg/ml
(mg)
%Drug
Release
mcg/ml
(mg)
%Drug
Release
15
3.41
30.66
15.33
2.69
24.24
12.12
30
4.71
42.4
21.2
4.12
37.04
18.52
60
6.33
57
28.5
5.40
48.56
24.28
90
7.13
64.2
32.1
6.51
58.6
29.3
120
8.92
80.24
40.12
7.83
70.44
35.22
150
9.89
89.04
44.52
9.13
82.2
41.1
180
11.02
99.14
49.57
10.49
94.44
47.22
210
11.64
104.72
52.36
11.44
102.94
51.47
240
13.21
118.88
59.44
12.49
112.44
56.22
270
14.76
132.84
66.42
13.81
124.26
62.13
300
15.83
142.46
71.23
15.21
136.88
68.44
330
17.01
153.08
76.54
16.09
144.8
72.4
360
19.65
176.86
88.43
17.39
156.5
78.25
390
20.48
184.36
92.18
19.18
172.64
86.32
420
21.62
194.56
97.28
20.48
184.3
92.15
2. HPMC
n=1
n=2
Time
(Min)
mcg/ml
(mg)
%Drug
Release
mcg/ml
(mg)
%Drug
Release
15
2.45
22.04
11.02
3.16
28.44
14.22
30
3.37
30.36
15.18
4.06
36.5
18.25
60
4.29
38.64
19.32
4.76
42.88
21.44
90
5.93
53.4
26.7
5.90
53.06
26.53
120
7.02
63.2
31.6
7.51
67.62
33.81
150
7.61
68.5
34.25
8.11
73
36.5
180
8.54
76.9
38.45
8.94
80.5
40.25
210
9.76
87.8
43.9
10.12
91.1
45.55
240
10.30
92.66
46.33
10.81
97.3
48.65
270
11.16
100.42
50.21
11.44
102.94
51.47
300
11.65
104.82
52.41
12.05
108.46
54.23
330
12.91
116.22
58.11
13.10
117.88
58.94
360
13.85
124.62
62.31
14.80
133.16
66.58
390
15.43
138.86
69.43
16.08
144.72
72.36
420
16.48
148.3
74.15
17.42
156.82
78.41
3. ETHYL CELLULOSE
n=1
n=2
Time
(Min)
mcg/ml
(mg)
%Drug
Release
mcg/ml
(mg)
%Drug
Release
15
1.89
17
8.5
2.78
25.02
12.51
30
2.74
24.7
12.35
3.16
28.4
14.2
60
4.14
37.28
18.64
3.67
33
16.5
90
5.24
47.14
23.57
4.62
41.6
20.8
120
5.66
50.96
25.48
6.41
57.68
28.84
150
6.36
57.28
28.64
6.72
60.48
30.24
180
7.19
64.74
32.37
7.87
70.8
35.4
210
8.05
72.42
36.21
8.58
77.2
38.6
240
9.24
83.16
41.58
9.03
81.24
40.62
270
9.70
87.3
43.65
9.96
89.62
44.81
300
10.83
97.44
48.72
10.70
96.3
48.15
330
11.66
104.96
52.48
11.17
100.52
50.26
360
12.79
115.1
57.55
12.07
108.62
54.31
390
13.81
124.26
62.13
13.05
117.42
58.71
420
14.73
132.56
66.28
13.83
124.44
62.22