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PRACTICAL REPORT

To prepare and evaluate Ibuprofen matrix tablets and


observes the effect of different polymer (Methyl cellulose,
Hydroxy propyl methyl cellulose and Ethyl cellulose) on drug
release profile.

Submitted to
Prof. N.K.Jain

Submitted by
Surbhi Dubey
Saket Asati
Amit Verma

Object: To prepare and evaluate Ibuprofen matrix tablets and observes the
effect of different polymer (Methyl cellulose, Hydroxy propyl methyl cellulose
and Ethyl cellulose) on drug release profile.
1. Hardness Testing:
Tablet

Hardness (Kg); [Drug:Polymer]


HPM
C

1st

2nd

5.5

3rd

Avera
ge

MC

Avera
ge

EC

5.5

3.5

5.16

Average

5.5

3.16

5.66

2. Friability Testing:
S.

Weight of tablets; [Drug:


polymer] (in g)

No
.

% friability; [Drug: polymer]

Before
HPM

MC

After
EC

HPM

MC

EC

HPM

Avg

6.10

6.20

6.23

6.06

6.17

6.18

0.65

6.33

6.34

6.18

6.28

6.29

6.14

0.78

MC

Av
g.

0.48
0.74

0.78

vg.
0.8

0.6

0.64

6.15

6.25

6.30

6.10

6.20

6.26

0.81

0.8

0.63

0.69

3. Weight Variation Testing:


S.
No.
1

Individual Weight
Polymer
HPMC
MC
0.53
0.56

(mg) Drug: % Wight variation Drug:


Polymer
EC
HPMC
MC
EC
0.56
3.63
1.81
1.81

0.54

0.55

0.56

-1.81

1.81

0.55

0.57

0.54

3.63

-1.81

0.56

0.55

0.55

1.81

0.55

0.54

0.54

-1.81

-1.81

0.53

0.53

0.58

-3.63

-3.63

-5.4

0.58

0.55

0.55

5.4

0.55

0.56

0.57

1.81

3.63

0.57

0.57

0.56

3.63

3.63

1.81

10

0.54

0.56

0.55

-1.81

1.81

11

0.55

0.58

0.54

5.4

-1.81

12

0.56

0.55

0.52

1.81

-5.4

13

0.57

0.54

0.55

3.63

-1.81

14

0.56

0.56

0.54

1.81

1.81

-1.81

15

0.57

0.56

0.56

3.63

1.81

-1.81

16

0.55

0.54

0.55

-1.81

17

0.55

0.55

0.57

3.63

18

0.56

0.57

0.56

1.81

3.63

1.81

19

0.54

0.55

0.55

-1.81

20

0.53

0.56

0.55

-3.63

1.81

1. METHYL CELLULOSE (1:1)

n=1

n=2

Time
(Min)

mcg/ml

(mg)

%Drug
Release

mcg/ml

(mg)

%Drug
Release

15

3.41

30.66

15.33

2.69

24.24

12.12

30

4.71

42.4

21.2

4.12

37.04

18.52

60

6.33

57

28.5

5.40

48.56

24.28

90

7.13

64.2

32.1

6.51

58.6

29.3

120

8.92

80.24

40.12

7.83

70.44

35.22

150

9.89

89.04

44.52

9.13

82.2

41.1

180

11.02

99.14

49.57

10.49

94.44

47.22

210

11.64

104.72

52.36

11.44

102.94

51.47

240

13.21

118.88

59.44

12.49

112.44

56.22

270

14.76

132.84

66.42

13.81

124.26

62.13

300

15.83

142.46

71.23

15.21

136.88

68.44

330

17.01

153.08

76.54

16.09

144.8

72.4

360

19.65

176.86

88.43

17.39

156.5

78.25

390

20.48

184.36

92.18

19.18

172.64

86.32

420

21.62

194.56

97.28

20.48

184.3

92.15

2. HPMC

n=1

n=2

Time
(Min)

mcg/ml

(mg)

%Drug
Release

mcg/ml

(mg)

%Drug
Release

15

2.45

22.04

11.02

3.16

28.44

14.22

30

3.37

30.36

15.18

4.06

36.5

18.25

60

4.29

38.64

19.32

4.76

42.88

21.44

90

5.93

53.4

26.7

5.90

53.06

26.53

120

7.02

63.2

31.6

7.51

67.62

33.81

150

7.61

68.5

34.25

8.11

73

36.5

180

8.54

76.9

38.45

8.94

80.5

40.25

210

9.76

87.8

43.9

10.12

91.1

45.55

240

10.30

92.66

46.33

10.81

97.3

48.65

270

11.16

100.42

50.21

11.44

102.94

51.47

300

11.65

104.82

52.41

12.05

108.46

54.23

330

12.91

116.22

58.11

13.10

117.88

58.94

360

13.85

124.62

62.31

14.80

133.16

66.58

390

15.43

138.86

69.43

16.08

144.72

72.36

420

16.48

148.3

74.15

17.42

156.82

78.41

3. ETHYL CELLULOSE

n=1

n=2

Time
(Min)

mcg/ml

(mg)

%Drug
Release

mcg/ml

(mg)

%Drug
Release

15

1.89

17

8.5

2.78

25.02

12.51

30

2.74

24.7

12.35

3.16

28.4

14.2

60

4.14

37.28

18.64

3.67

33

16.5

90

5.24

47.14

23.57

4.62

41.6

20.8

120

5.66

50.96

25.48

6.41

57.68

28.84

150

6.36

57.28

28.64

6.72

60.48

30.24

180

7.19

64.74

32.37

7.87

70.8

35.4

210

8.05

72.42

36.21

8.58

77.2

38.6

240

9.24

83.16

41.58

9.03

81.24

40.62

270

9.70

87.3

43.65

9.96

89.62

44.81

300

10.83

97.44

48.72

10.70

96.3

48.15

330

11.66

104.96

52.48

11.17

100.52

50.26

360

12.79

115.1

57.55

12.07

108.62

54.31

390

13.81

124.26

62.13

13.05

117.42

58.71

420

14.73

132.56

66.28

13.83

124.44

62.22

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