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Gout

ANATOMIC LOCATION Articular cartilage and periarticular soft tissue. CLINICAL INFORMATION Associated with enzyme defects, increased nucleic acid turnover, chronic renal disease, alcohol, obesity, and drugs.

HISTOLOGY If fixed in alcohol, needle shaped, doubly refractile crystals surrounded by granulomatous reaction with abundant foreign body giant cells. If fixed in formalin, crystals not visible but histology still diagnostic.