PATHOPHYSIOLOGY

Non-Modifiable Factors: - Age: 56 y/o - Male - Genetics -Race: Asians Modifiable Factors: - Ignores physicians advice - Occupation: Engineer - Sedentary Lifestyle

Chronic irritation of liver cells

Prolonged inflammation

Chronic liver injury Cell Mutation Rapid uncontrollable proliferation of anaplastic cells

Angiogenesis

Tumor growth in the liver

Liver stretches to accommodate growing tumor

Compresses blood vessels and nerve endings

Altered liver function Cell starvation Fatigue & Necrosis Stored fat is lost

hepatomegaly

Compresses hepatic veins Compression of common bile duct Decreased/ absence of bile in the intestine Backflow of blood to lower extremities

Tissue loses nitrogen balance

Fluid leaks into the extracellular compartment

Anaerobic metabolism

Accumulation of unconjugated bilirubin in the blood

steatorrhea

ascites

Dependent edema

Consumes glucose

Pruritus

Jaundice

Increased amounts of bile in the urine

Decreased glycogen stores & conversion of glucose to lactate

Compresses the diaphragm

dyspnea

Tea colored urine Hypoglycemia

Compresses the stomach

Decreased capability of the stomach to fully expand Vasovagal stimulation

Sends signal to the satiety center of hypothalamus

Anorexia Refusal to eat Taste sensation diminishes

LIVER CANCER