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Neuroantomic Bipolar Disorder

Risk Factors Circuits

Ashley Dean
Contributing
Anatomical
Changes of Brain
RNSG1263
Unknown
Factors

Genetic Limbic-Thalamic-Cortical
&
Limbic-Striatal-Pallidal-Cortical
Circuits
Biochemical

Frontal & Temporal Lobes Hippocampus


Neuroanatomic Of Forebrain
Circuits

Enlargement of Third
Pre-Frontal Cortex
and Lateral Ventricles Reduction in #
of Glial Cells

Basil Ganglia & Reduction in


Parts of the Limbic System Volume of Grey Matter
Reduction in #
of Neurons
Genetics

Manifestations Bipolar Disorder Complex and


Non-Mendelian

Promiscuous
Depression
Behaviour
Iinteractions of
Multiple Genes
Anxiety Overspending

genomic imprinting,
Verbally & mitochondrial inheritance
Phobias
Physically Abusive

Complications
Suicide Substance Abuse

Inability to
Care for Self
Smoking
Higher Incident of
Physical Illness Financial Ruin
Alcohol Abuse
Reduction concentration
Heart Disease Migraines Social Alienation Increase in plasma of HVA – a major
Noradrenaline during Mania Dopamine metabolite
Cocaine or Marijuana

Asthma Cancer Death Reduced concentration Depleted levels of Noradrenaline,


of Serotonin metabolite Seratonin and/or Dopamine
5-HIAA in CNS during Depression

GI Disorders Heart Disease Hospitalization


or Jail
Reduced density of Reduction of choline
Serotonin 1A Receptors in erythrocytes
Loss of Family,
Diabetes
Friends& Job

Biochemistry

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