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SISTEMUL NERVOS

AUTONOM
Dr. Radu BRAGA
radu.braga@univermed-cdgm.ro
Neuroni Neuroni
SISTEM
NERVOS
MEDIU
EXTERN
MEDIU
INTERN
senzoriali senzoriali
CENTRAL
EXTERN
INTERN
Neuroni
motori
Neuroni
motori
Sistem nervos autonom
Sistem nervos
senzorial-somatic
Conservarea energiei
Conservarea energiei Fuga sau lupta
Balanta
sistemelor sistemelor
nervoase
autonome
Activitate parasimpatica Activitate simpatica
CONTROLUL CENTRAL AL SNA CONTROLUL CENTRAL AL SNA
Cortex insular Cortex insular
cx. viscerosenzorial pt. chemorec.&barorec.
arteriali arteriali
Cx. Ventromedial prefrontal&cingulat ant.
Comportament afectiv Comportament afectiv
Amigdala
Asociaza inf. afectiva pt inf. extero- si
interoceptiva
Hipotalamus Hipotalamus
Periventriculara
Ritmicitate raspuns endocrin Ritmicitate, raspuns endocrin
Mediala
F sexuala osmo- termoreglare
Nc. trunchi
cerebral &
d l i
F. sexuala, osmo , termoreglare
Comportament alimentar
Laterala
medulari
Laterala
Alerta comportamentala
REGLAREA SNA REGLAREA SNA
c. spinotalamice
c. spinoreticulate
n. IX, n. X
CALEA DE CONDUCERE A SN
AUTONOM AUTONOM
Cale autonoma
Neuron
preganglionar
Neuron
postganglionar
Ganglion Tesut
SNC
Ganglion
autonom
Tesut
tinta
Cale simpatica
Cale parasimpatica
Cale
comunicanta
i
Cale
comunicanta
alba
cenusie
SN AUTONOM
SIMPATIC SIMPATIC
N S i l N. Spinal
Lant
ganglionar
paravertebral
N. Autonom
RECEPTORI ADRENERGICI RECEPTORI ADRENERGICI
Receptor Localizare Sensibilitate MS
1
Maj. tes. int
simpatice
NA>A Activeaza
PLC + IP3 simpatice PLC + IP3
2
Tr. Gastrointest.
i pancreas
NA>A Inhiba cAMP
i pancreas
1
Miocard, Rinichi NA=A Activeaza
cAMP
2
Vase snge, m.
neted
A>NA Activeaza
cAMP
3
Adipocite
ELIBERAREA MEDIATORILOR ELIBERAREA MEDIATORILOR
MEDULOSUPRARENALA MEDULOSUPRARENALA
SN AUTONOM
PARASIMPATIC PARASIMPATIC
PS
cranian cranian
PS sacrat PS sacrat
RECEPTORI COLINERGICI RECEPTORI COLINERGICI
Tip receptor Mecanism Localizare
M1 Stimulare PLC SNC N postgangli M1 Stimulare PLC SNC,N.postgangli
onar ps.
M2 Inhiba cAMP Miocard,m.neted
M3 Stimuleaza PLC Tes. Glandular, m.
neted vasc.
M4 I hib AMP SNC M4 Inhiba cAMP SNC
M5 Stimuleaza PLC SNC
Nicotinic SNC Depolarizare SNC Nicotinic SNC Depolarizare
deschide c. Na+K
SNC
Nicotinic Gg.
Idem
Gg.Autonom Nicotinic Gg. Gg.Autonom
Nicotinic mm.
idem
J. neuromusc.
Transmitere la nivelul gg autonom Transmitere la nivelul gg. autonom
Transmisie colinergica - cord Transmisie colinergica cord
Transmisie non-adrenergic, non-
li i colinergic
Gastrin releasing peptide (GRP) & Vasoactive intestinal peptide
(VIP) (VIP)
=> cotransmitori pregg simpatici
Neuropeptidul Y & Somatostatin Neuropeptidul Y & Somatostatin
=> cotransmisie fibre postgg
Enkephalina, Substana P, NPY Enkephalina, Substana P, NPY
=> cotransmisie parasimpatic
ATP, NPY, VIP neurotransmitori independeni n SNA p
(VIP&ACh cotransmisie frecvent PS vase sge, gl. exocrine)
SNE VIP&NO relaxeaz sfincterele, cresc secreia
NO neuroni nitrergici
REGLAREA SNA REGLAREA SNA
c. spinotalamice
c. spinoreticulate
n. IX, n. X
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