ANTIDIABETICELE ORALE

SULFONILUREICELE
insulinosecretagoge - acioneaz la nivel pancreatic (stimuleaz secreia de insulin prin nchiderea canalelor
de K-ATP) i extrapancreatic (mai slab); hipoglicemiante
Generaia a II-a
D.C.I. Denumire comercial Doz maxim/zi
glibenclamid
Glibenclamid 5 mg 15 mg
Maninil 1,75 mg; 3,5 mg 10,5 mg
gliclazid
Diaprel MR 30 mg 90 mg
Diclazid 80 mg 240 - 320 mg
Esquel 80 mg 240 - 320 mg
glipizid Glucotrol XL 5 mg; 10 mg 10 - 20 mg
gliquidon i n IRC Glurenorm 30 mg 90 - 120 mg
Generaia a III-a
glimepirid Amaryl 1 mg; 2 mg; 3 mg 6 mg
MEGLITINIDELE
mecanism comun de aciune cu al sulfonilureicelor, dar realizat prin legarea de receptor la un situs diferit;
hipoglicemiante
repaglinid NovoNorm 0,5 mg; 1 mg; 2 mg 8 mg
BIGUANIDELE
antihiperglicemiante; mecanism de aciune incert: acioneaz cu precdere la nivel hepatic (producia
hepatic de glucoz prin diminuarea glicogenolizei i a gluconeogenezei) dar i periferic (stimularea captrii
musculare a glucozei mediat de insulin)
metformin
Glucophage 500 mg; 850 mg; 1000 mg 3000 mg
Meguan 500 mg; 850 mg 3000 mg
Metfogamma 500 mg; 850 mg; 1000 mg 3000 mg
Metformin 500 mg; 850 mg; 1000 mg 3000 mg
Siofor 500 mg; 850 mg; 1000 mg 3000 mg
buformin Silubin Retard 100 mg 200 mg
THIAZOLIDINDIONELE (GLITAZONELE)
antihiperglicemiante prin insulinosensibilitii la nivelul organelor int (esut adipos, musculatur scheletic,
ficat), fiind agoniti direci i competitivi ai PPAR
pioglitazona Actos 15 mg; 30 mg; 45 mg 45 mg
rosiglitazona Avandia 4 mg 8 mg
INHIBITORII ALFA-GLUCOZIDAZEI
inhib glucoamilaza, sucraza, maltaza prin legarea reversibil de aceste enzimese ncetinete digestia i
absorbia HC de-a lungul intestinului subirepeak-ul postprandial al glicemiei
acarboza Glucobay 50 mg; 100 mg 300 mg
INHIBITORI DE DPP-4
insulinosecretagoge din grupa incretinelor; inhib DPP-4, astfel nct GLP-1 rmne activ i
stimuleaz secreia de insulin din celula beta
sitagliptina Januvia 100 mg 100 mg
COMBINAII FIXE
GLIBOMET 2,5 mg glibenclamid + 400 mg metformin 2 g metformin
AVANDAMET 1, 2, 4 mg rosiglitazon + 500, 1000 mg metformin 8 mg rosiglitazon
COMPETACT 15 mg pioglitazon + 850 mg metformin 45 mg pioglitazon
JANUMET 50 mg sitagliptin + 500 mg / 1000 mg metformin 2 g metformin
D.C.I. Denumire comercial
Trofice nervoase
acidum alfa-lipoicum (acidum thiocticum)
Thiogamma 600 mg
Thiogamma sol. inj. 30 mg/ml
50 mg benfotiamin + 250 g
ciancobalamin
Milgamma
40 mg benfotiamin + 90 mg piridoxin
clorhidrat + 250 g ciancobalamin
Milgamma N
Medicaie hipolipemiant
Statinele inhib HMG CoA reductaza
rosuvastatin Crestor 10-20-40 mg
atorvastativ Sortis 10-20-40-80 mg
simvastatin
Simcor 20-40 mg
Simvastatin 10-20-40 mg
Vasilip 10-20-40 mg
Zocor 10-20-40 mg
Fibraii agoniti de PPAR, stimuleaz lipoproteinlipaza
fenofibrat
Lipanthyl Supra 160 mg
Fenofibrat LPH 200 mg
bezafibrat Regadrin-B 200 mg
ciprofibrat Lipanor 100 mg
Tratamentul hiperuricemiilor
Uricofrenatoare (inhib biosinteza acidului uric)
allopurinol Allopurinol 100 mg
Tratamentul atacului acut de gut i profilaxia recurentelor
colchicinum Colchicin 1 mg
Tratamentul obezitii
orlistat Xenical 120 mg
sibutramina
Reductil 10 mg; 15 mg
Lindaxa 10 15 mg
Tratamentul hipertensiunii arteriale
Inhibitorii enzimei de conversie a angiotensinei
lisinopril
Lisigamma 5-10-20 mg
Lisinopril 10-20-40 mg
perindopril Prestarium 4-8 mg
quinapril Accupro 5-10-20 mg
ramipril
Tritace 2,5-5-10 mg
Ampril 1,25-2,5-5-10 mg
captopril Captopril 12,5-25-50 mg
enalapril
Enap 2,5-5-10 mg
Renitec 5-10-20 mg





Inhibitori ai receptorului de angiotensin II
candesartan cilexetil Atacand 8-16 mg
eprosartan Teveten 400, 600 mg
irbesartan Aprovel 150, 300 mg
losartan
Cozaar 50 mg
Lorista 50 mg
telmisartan
Micardis 40, 80 mg
Pritor 40, 80 mg
valsartan Diovan 40, 80, 160 mg
Diuretice
indapamidum
Tertensif SR 1,5 mg
Indapamida 1,5-2,5 mg
hidroclorothiazida Nefrix 25 mg
spironolactona + furosemid Diurex 50 100 mg
Blocante ale canalelor de calciu
amlodipina
Amlodipin 5, 10 mg
Amlohexal 5, 10 mg
Norvasc 5, 10 mg
Tenox 5, 10 mg
diltiazem
Diacordin 60 mg
Dilzem Retard 90 mg
Beta-blocante
atenololum Atenolol 50, 100 mg
betaxolol Lokren 20 mg
bisoprolol
Bisogamma 5, 10 mg
Concor 2,5-5-10 mg
carvedilol Carvedilol 3,125; 6,25; 12,5; 25 mg
nebivolol Nebilet 5 mg
Altele
pentoxifilin Pentoxi Retard 400 mg, 600 mg
acenocumarol Acenocumarol 2 mg
Sintrom 4 mg
Trombostop 2 mg
isosorbid dinitrat Dinicord Retard/SR 20/40 mg
Maycor Retard 20 mg
isosorbid mononitrat Mononitron EP 60 mg
Olicard 40, 60 mg
piracetam Piracetam 400; 800 mg
Nootropil 800; 1200 mg
trimetazidin Dilatan 20 mg/MR 35 mg
Preductal 20 mg/MR 35 mg
Trimetazidin 20, 35 mg
2 4 mg perindopril + 0,625 - 1,25 mg
indapamid
Noliprel