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Orthomixoviridae

Orthomixoviridae
v. gripale A, B, C
virioni sferici, nucleocapsid helical
ARN m.c.-, segmentat (8/7)
anvelop, 2 glicoproteine
hemaglutinina - ligand
neuraminidaza sialidaz
acces spre receptori celulari
eliberarea virionilor dup morfogenez
previne autoagregarea virionilor
Habitat
A om, mamifere, psri
B, C - om
Structura Ag
variaie Ag a glicoproteinelor de
anvelop (A, B)
variaia Ag minor mutaii
variaia Ag major A reasortri
genomice ntre subtipuri virale
Infecia natural.
Infecia natural.
P
P
atogeneza
atogeneza
mucoasa respiratorie fluidific mucusul
(N) receptori celulari necroza celular
vindecare 3-7Z (If)
v. prezent n nasofaringe 1-2Z nainte de
debut, 1-2Z dup vindecarea clinic
suprainfecii bacteriene datorit
dezorganizrii transportului mucociliar
complicaii
pneumonii v. gripal/ bacteriene (S. aureus -
- sinergism, S. pneumoniae, H. influenzae)
sdr. Reye
Imunitate
Imunitate
IgA anti-H previn infecia
IgA anti-N previn infecia invaziv,
limiteaz contagiozitatea bolii
variaii Ag minore f. uoare de boal
subtipuri pandemice mbolnviri grave
Ac fixatori complement persist cteva L
Ac inhibitori ai hemaglutinrii persist
ani
Diagnostic
Diagnostic
diagnostic direct
tampon/ spltur, faringian()/ nasal()
izolare pe ou embrionate/ c.c.
depistare rapid: IF, ELISA, sonde acizi
nucleici, PCR
diagnostic serologic
ser acut, ser convalescent
seroconversia/ dinamica semnificativ Ac
RFC, RIH, ELISA
Tratament
amantadina, rimantadina
CI derivate acid acetilsalicilic (! sdr. Reye)
tratament patogenetic, AB previn suprainfecia
bacterian
Epidemiologie
sursa de infecie om/ animale
transmitere picturi Flgge, mini i obiecte
contaminate
Profilaxie
vaccin integral inactivat (conine proteine de ou)
vaccinuri purificate (fraciuni de virion/ Ag de suprafa)
vaccinare selectiv/ electiv
chimioprofilaxie electiv
Influenza A Evolution
1874 --- (H3N8)
1890 --- (H2N2) .........................Pandemic
1902 --- (H3N2)
1918 --- (H1N1)..........................Pandemic
1933 --- (H1N1)..........................First strains isolated
1947 --- (H1N1)..........................Variation detected
1957 --- (H2N2).........................."Asian" Flu pandemic
1968 --- (H3N2).........................."Hong Kong" Flu
pandemic
1976 --- (H1N1).........................."Swine" Flu, non-
epidemic
1977 --- (H1N1) + (H3N2)........."Russian" Flu epidemic