Vitamin A

Deciency
Night blindness (2nd MCC world wide
Squamous metaplasia
Xerophthalmia
Bitot's spot
Keratomalasia
Follicular Hyperkeratosis (goose-bumps)
PNA
Renal Calculi
Causes
Fat malabsorption
Celiac dz
Cystic Fibrosis
Whipple's dz
Diet
Yellow/green vegetables
Toxicity
Acute toxicity (1x dose) CNS symptoms (N,Vertigo, Blurred Vison)
Chronic toxicity (2+ doses) Cerebral Edema/hepatotoxicity
Teratogenic (1st trimester)
Beta carenemia White sclera w/ yellow skin
Tx for
ATRA for AML M3
Mealses infection
Vitamin D
Deciency
Rickets (children)
Osteomalacia (adults)
Toxicity Hypercalcemia
Metastatic calcication Renal failue
Renal Calculi (MC type of stone)
Causes
Sun exposure decr. 7-dehydrochlesterol
Renal Dz 1a-hydroxylation
Liver failure decr. 25-OH-D Drug induced ETOH
Phenytoin
Barbiturates
Fat Malabsorption
Vitamin E
Deciency Hemolytic anemia Hemolytic dz of Newborn (premi)
CNS symptoms (ataxia, DCML)
Toxicity Hemorrhagic diathesis Decr. Vit K syn
Potentiates Warfarin e!ects
Causes Chronic fat malabsorption CF (MCC)
Celica Dz
Whipple dz
Vitamin K
Deciency
Hemorrhagic disease of Newborn (Type II HSR)
Hemorrhage GIT
Incr. PT & PTT
Vit K dependent factor
(2, 7, 9, 10, Protein C & S)
Causes Fat malabsorption
Broad-spectrum Abx use
Newborns No colonic bacteria
Liver Failure Cirrhosis
Warfarin