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Acute and Chronic inflammation MCQ

Regarding acute inflammation


a) Initial vasoconstriction is the result of histamine and nitric oxide
b) Stasis occurs due to vasodilatation and the larger caliber of vessels
c) Increased permeability leads to protein depleted plasma leaking into the tissue
d) Initial formation of endothelial gaps lasts for only !"#$ minutes
e) Cytokines %I&" and '()) are responsible for the early permeability
*istamine is involved in acute inflammatory responses and is released from mast
cells+ ,hich of the follo-ing statements is incorrect.
a) It is found in blood basophils/ platelets and mast cells
b) It causes increased permeability of arterioles
c) It may be released by physical trauma
d) It causes constriction of large vessels
e) It acts on the microcirculation via * receptors
Complement
a) 0roteins are usually stored in an active state in lysosomal molecules
b) 0ath-ay is inhibited by C# cleavage
c) C# is the most abundant protein in the complement family
d) Activation by the classical path-ay involves microbial surface antigens
e) Cobra venom activates the lectin path-ay
Regarding mediators of inflammation
a) '() is a chemokine -ith chemoattractant properties
b) '() contributes to cachexia of disease
c) '() and I&" are produced mainly by activated leukocytes
d) 'he systemic acute phase response is induced by MI0" and RA('1S
chemokines
e) 0A) causes vasodilation -hen expressed at high levels
Chronic inflammation is characteri2ed by all of the belo- except
a) 'issue destruction
b) Angiogenesis
c) Infiltration -ith neutrophils
d) )ibrosis
e) Increased tissue concentration of lymphocytes
) d
3) c
#) c
4) b
!) c