Our Knowledge-Driven Panel Design

options to patients.

> 120
FDA Approved

> 320
Cancer
Drug Targets

> 350
Cancer Drugs

MolecularHealths
Targeted Panel

> 230
Indications
> 5000
Clinical Trials

Analysis
of 3 Million
Oncology

> 500
Gene Panel

Endorsed

> 160
Predictive
Biomarker
Genes

Observed in
> 100 Cancer
Indications

Publications

Clinical

Translational

Cancer Drug Targets: Typically a gene/protein that is bound by anti-cancer drugs to elicit a
therapeutic effect.
Cancer Drugs: A pharmacological/biological agent that is administered to patients to kill cancer cells.
Predictive Biomarker Genes: A gene whose biological status (e.g. expression level or DNA sequence)
is useful in predicting the effect of drug therapies.
Endorsed Biomarker: A biomarker whose clinical utility is endorsed by regulated agency (FDA).
Clinical: A biomarker that has been observed in patients to predict the effect of a drug.
Translational: A biomarker that has been observed in model systems to predict the effect of a drug.
Indications:

ABCB1

BIRC5

CDH20

DHFR

FANCL

GSTO2

ITGB5

MLL

PARP8

PTCH1

SOD2

TNFSF13

ABCC1

BLM

CDH5

DIABLO

FAS

GSTP1

ITGB6

MLL2

PAX5

PTCH2

SOX10

TNFSF13B

ABCC2

BMI1

CDK1

DKK1

FASLG

GUCY1A2

ITK

MMP2

PBRM1

PTEN

SOX2

TNKS

ABCC6

BMP10

CDK12

DLL4

FBXW7

GUSB

ITPA

MPL

PDCD1

PTGS2

SPEN

TOP1

ABCG2

BRAF

CDK2

DNMT3A

FGF1

HBB

JAK1

MRE11A

PDCD1LG2

PTH

SPG7

TOP2A

ABL1

BRCA1

CDK4

DOT1L

FGF10

HBEGF

JAK2

MS4A1

PDGFB

PTK2B

SPOP

TOR1A

ABL2

BRCA2

CDK6

DPP4

FGF14

HDAC1

JAK3

MSH2

PDGFRA

PTPN11

SPP1

TP53

ACE

BRIP1

CDK7

DPYD

FGF19

HDAC11

JUN

MSH3

PDGFRB

PTPRC

SRC

TP63

ACPP

BTK

CDK8

E2F1

FGF2

HDAC2

KDM5A

MSH6

PDK1

PTPRD

SSTR1

TP73

ACVRL1

BUB1

CDK9

EDNRA

FGF23

HDAC6

KDM5C

MST1R

PDPK1

RAD50

SSTR2

TPMT

ADA

CA9

CDKN1B

EDNRB

FGF3

HFE

KDM6A

MSTN

PGF

RAD51

SSTR3

TRPM8

ADAM15

CALCA

CDKN2A

EEF2

FGF4

HGF

KDR

MTF1

PGR

RAD51L3

SSTR4

TSC1

AFP

CALCR

CDKN2B

EGFL7

FGF6

HIF1A

KEAP1

MTHFR

PHLPP2

RAF1

SSTR5

TSC2

AKT1

CALM1

CDKN2C

EGFR

FGFR1

HOXA3

KIF11

MTOR

PIK3CA

RARA

STAG2

TSHR

AKT2

CALM2

CDKN2D

EIF4EBP1

FGFR2

HPSE

KIR2DL1

MTR

PIK3CB

RB1

STAT3

TUSC2

AKT3

CALM3

CEACAM5

EML4

FGFR3

HRAS

KIT

MUTYH

PIK3CD

RET

STAT4

TYMS

ALK

CARD11

CEBPA

EMSY

FGFR4

HRH2

KLF4

MYC

PIK3CG

RHEB

STK11

TYR

ALOX12

CASP3

CENPE

ENG

FLT1

HSP90AA1

KLHL6

MYCL1

PIK3R1

RICTOR

SUFU

UBA52

ALOX12B

CASP7

CHEK1

EP300

FLT3

HSP90AB1

KLK2

MYCN

PIK3R2

RNF43

SULT1C4

UBB

ANGPT1

CASP8

CHEK2

EPCAM

FLT3LG

HSP90B1

KLK3

MYD88

PIM1

ROCK2

SYK

UBC

ANGPT2

CASP9

CIAPIN1

EPHA3

FLT4

HSPA5

KRAS

MYH11

PLA2G10

ROS1

UGT1A1

APC

CBFB

CIC

EPHA5

FOLH1

IDH1

LAG3

MYST3

PLA2G12A

RPE65

TACR1

UGT1A7

AR

CBL

CLDN18

EPHA6

FOLR1

IDH2

LGALS1

NAE1

PLA2G12B

RPS27A

TBX22

UMPS

ARAF

CBR3

CLU

EPHA7

FOXL2

IFNA2

LHCGR

NAMPT

PLA2G1B

RPTOR

TEC

USP9X

ARFRP1

CCL3

CREBBP

EPHB1

FOXP4

IFNB1

LOXL2

NAT2

PLA2G2A

RRM2

TEK

VCAM1

ARID1A

CCND1

CRKL

EPHB4

FYN

IFNG

LPA

NCF2

PLA2G2D

RUNX1

TERT

VDR

ARID2

CCND2

CRLF2

EPHB6

FZD1

IGF1R

LRP1B

NCL

PLA2G2E

RUNX3

TET1

VEGFB

ASXL1

CCND3

CSF1R

ERBB2

FZD10

IGF2R

LRP2

NF1

PLA2G2F

S100A9

TET2

VEGFC

ATM

CCNE1

CSF2

ERBB3

FZD2

IKBKE

LRP6

NF2

PLA2G3

S1PR1

TGFB1

VHL

ATP1A3

CCNG1

CTCF

ERBB4

FZD5

IKZF1

LTA

NFE2L2

PLA2G5

SELL

TGFBR1

VKORC1

ATP7A

CCR4

CTLA4

ERCC2

FZD7

IL11RA

LTF

NFKB1

PLA2G6

SELP

TGFBR2

VPS4B

ATR

CCR5

CTNNA1

ERCC5

FZD8

IL13

LTK

NFKBIA

PLAU

SERPINA1

TGM2

VWF

ATRX

CD109

CTNNB1

ERG

G6PD

IL13RA2

LYN

NGF

PLCG1

SERPINE1

TH

WISP3

AURKA

CD151

CTSG

ESR1

GATA1

IL1A

MAGEA1

NKX2-1

PLK1

SETD2

TLR2

WT1

AURKB

CD19

CXCL12

ESR2

GATA2

IL2

MAGEA4

NOD2

PLK4

SF3B1

TLR3

XIAP

AURKC

CD22

CXCR1

ETV1

GATA3

IL21R

MAP2K1

NOTCH1

PMP22

SFTPC

TLR4

XPC

AVPR2

CD248

CXCR2

ETV4

GATA4

IL25

MAP2K2

NOTCH2

PNP

SHH

TLR5

XPO1

AXL

CD274

CYBA

ETV5

GDF2

IL29

MAP2K4

NOTCH3

POLD1

SLC10A3

TLR7

XRCC1

BAD

CD37

CYP11B1

ETV6

GGH

IL2RA

MAP3K1

NPM1

POLE

SLC16A1

TLR8

XRCC2

BAP1

CD38

CYP11B2

EWSR1

GID4

IL4

MAPK1

NQO1

PPARA

SLC19A1

TLR9

YES1

BARD1

CD4

CYP17A1

EZH2

GLP2R

IL4R

MAPK3

NR4A1

PPARD

SLC29A1

TMPRSS2

ZEB2

BBC3

CD40

CYP19A1

F13B

GNA11

IL7R

MCL1

NRAS

PPARG

SLC5A5

TNC

ZNF217

BCL2

CD44

CYP1B1

F2

GNA13

INHBA

MDM2

NRP2

PPP2R1A

SLC6A2

TNF

ZNF703

BCL2A1

CD52

CYP2C19

F3

GNAQ

INSR

MDM4

NTRK1

PRAME

SLC7A11

TNFAIP3

BCL2L1

CD70

CYP2C8

F5

GNAS

IRF4

MED1

NTRK2

PRDM1

SLCO1B1

TNFRS-

BCL2L2

CD74

CYP2C9

FAM123B

GNRHR

IRS2

MED12

NTRK3

PRKAR1A

SMAD2

F10A

BCL6

CD79A

CYP2D6

FAM46C

GPC3

ITGA1

MEF2B

NUP93

PRKCA

SMAD3

TNFRS-

BCOR

CD79B

CYP3A4

FANCA

GPR124

ITGA5

MEFV

OPRD1

PRKCB

SMAD4

F10B

BCORL1

CDA

CYP4B1

FANCC

GRIN2A

ITGAM

MEN1

P2RX7

PRKDC

SMARCA4

TNFRSF14

BCR

CDC7

DAXX

FANCD2

GRIN3B

ITGAV

MET

PAK3

PRLR

SMARCB1

TNFRSF4

BGLAP

CDC73

DCT

FANCE

GRM3

ITGB1

MGMT

PALB2

PRSS1

SMC4

TNFRSF8

BIRC2

CDH1

DDR2

FANCF

GSK3B

ITGB2

MITF

PARP1

PSMB5

SMO

TNFRSF9

BIRC3

CDH2

DDX5

FANCG

GSTO1

ITGB3

MLH1

PARP2

PSMB8

SOCS1

TNFSF10

result of any kind. This test was developed and its performance characteristics determined by MolecularHealth, Inc. It has not been cleared or approved by the U.S. Food and Drug Administration.

www.molecularhealth.com

Rev 06-2014