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s
Dr. Mejbah Uddin
Ahmed
• Caused by poliovirus
• Destroys nervous system paralysis
Poliovirus
• Nonenveloped, ssRNA virus of the
Picornavirus family and Enterovirus group
• Nonenveloped, ssRNA.
• Three serotypes: type-1, type-2, type-3
• Reservoir: humans only
• Transmitted through fecal-oral route.
Transmission& pathogenesis
• Entry into mouth
• Replication in pharynx & GI tract in local
lymphoid tissue
• Hematogenus spread to central nervous
system
• Virus can also spread along nerve fibers
• Virus replicates in the anterior horn cells of
spinal cord
• Destruction of motor neurons & alos affect
brainstem
Polio Infection