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ANTIBIOTIC

PENICILINA G

DOZELE DE PENICILINE NATURALE


DOZE ADULI / ZI
DOZE COPIL / ZI
1-20 mil.UI, im/iv, 4/6/12 h
50.000-200.000 U/kg

PENICILINA V
EXTENCILINE
(BENZATHIN
PENICILINA G)

3-4 mil.U, po, la 6/8 h


1,2 mil. U/15 zile sau
2,4 mil.U/lun

50.000-100.000 U/kg
600.000 U/15 zile sau
1,2 mil U/lun

DOZELE DE PENICILINE REZISTENTE LA PENICILINAZE


ANTIBIOTIC
DOZE- ADULT
DOZE- COPIL
OXACILLINA/
2-4 g/zi (po:6/8 h; im,iv: 4-12 h)
50-100 mg/zi
NAFCILINA
CLOXACILINA
4-12 g/zi (im, iv: 5-6 h)
100-200 mg/kg/zi
DICLOXACILINA
1-4 g/zi (6-8 h)
50-100 mg/kg/zi

ANTIBIOTIC
AMPICILINA
AMOXICILINA
BACAMPICILINA
METAMPICILINA
PIVAMPICILINA
AMOXICILINA-AC.
CLAVULANIC
AMPICILINA-SULBACTAM

DOZE DE AMINOPENICILINE
DOZE - ADULT
Po:2-4 g/zi;
im,iv: 4-12 g/zi
Po, im, iv: 1-8 g/zi
0,8- 2,4 g/zi
2-12 g/zi
1-3 g/zi
2-3 g/zi
3- 4,5 g/zi

DOZE - COPIL
50-100 mg/zi
100-300 mg/zi
25- 200 mg/kg/zi
50-100 mg/kg/zi
50-200 mg/kg/zi
50-100 mg/kg/zi
30-40 mg/kg/zi
30-40 mg/kg/zi

DOZELE DE PENICILINE ANTIPSEUDOMONAS


ANTIBIOTIC
DOZE ADULT
DOZE COPIL
TICARCILINA
250 mg/kg/zi
75-100 mg/kg/zi
TICARCILINA + ACID CLAVULANIC
12,4- 18,6 g/zi
150-300 mg/kg/zi
MEZLOCILINA
6-15 g/zi
100-300 mg/kg/zi
PIPERACILINA
PIPERACILINA + TAZOBACTAM

6-15 g/zi
4,5- 13,5 g/zi

100-300 mg/kg/zi
100-300 mg/kg/zi

CARBAPENEME
ANTIBIOTIC
IMIPENEM

DOZE - ADULT
2 g/zi, iv

DOZE COPIL
30-60 mg/kg/zi

MEROPENEM
ERTAPENEM

3 g/zi, iv
1 g/zi, im,iv

40 mg/kg/zi

DOZELE DE CEFALOSPORINE DE PRIMA GENERAIE CIG


ANTIBIOTIC
DOZE ADULT
DOZE COPIL
CEFAZOLIN
1-6 g/zi, iv,im (la 6-8 h)
60 mg/kg/zi (la 8 h)
CEFADROXIL

1-2 g/zi, po

30 mg/kg/zi (la 12 h)

CEFALEXIN

1-2 g/zi, po (la 6h)

25-50 mg/kg/zi (la 6 h)

CEFALOSPORINE DE A DOUA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFAMANDOL
3-6 g/zi
CEFUROXIM
1,5- 4,5 g/zi, im,iv

DOZE COPIL
50-100 mg/kg/zi
50 mg/kg la 8 h, iv,
10-15 mg/kg x2/zi, po
10-15 mg/kg x 2 (max 1 g/zi)

CEFPROZIL

500 mg /zi, po

CEFOTETAN

CEFAMICINE:
2-6 g/zi, iv (la 12h)
30-60 mg/kg/zi

CEFOXITIN

3-6 g/zi , iv (la 4-8 h)

80-160 mg/kg/zi (la 6 h)

CEFALOSPORINE DE A TREIA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFOPERAZON
4 g/zi

DOZE COPIL
30-60 mg/kg/zi

CEFOTAXIMA

3-8 g/zi

50-100 mg/kg/zi

CEFTAZIDIMA
CEFTRIAXON

50-100 mg/kg/zi
50-75 mg/kg/zi

CEFTIZOXIMA
LATAMOXEF

3-6 g/zi
2 g/zi (<65 ani)
1 g/zi (>65 ani )
2-12 g/zi
2-6 g/zi

CEFIXIMA

ORALE
400 mg/zi, po

8 mg/kg/zi 2 prize

CEFPODOXIMA

200-400 mg/zi

10 mg/kg 2 prize

CEFTIBUTEN
CEFDINIR

400 mg/zi
600 mg/zi (1-2 prize)

4,5 mg/kg 2 prize


-

CEFALOSPORINE DE A PATRA GENERAIE


ANTIBIOTIC
DOZE ADULT
CEFEPIME
2-4 g/zi, iv
CEFPIROM

2-4 g/zi, iv

30-60 mg/kg/la 8h
-

DOZE COPIL
150 mg/kg/zi a 8 h

LINCOSAMIDE
ANTIBIOTIC
CLINDAMICINA

DOZE ADULT
0,6-2,4 g/zi, po, im, iv, (la 6-8 h)

LINCOMICINA

0,6-1,8 g/zi, im, iv, po (la 8 h)

DOZE COPIL
8-25 mg/kg, po
15-40 mg/kg, im,iv
30-60 mg/kg/zi, po
10-20 mg/kg/zi, im/iv

AMINOGLICOZIDE
ANTIBIOTIC
AMIKACINA

DOZE ADULT
15 mg/kg/zi (12-24 h)

DOZE COPIL
15 mg/kg/zi

DIBEKACINA

3 mg/kg/zi (12-24 h)

GENTAMICINA

3 mg/kg/zi (8,12,24 h)

2-4 mg/kg/zi

NETILMICINA

4-7 mg/kg/zi (8,12,24 h)

6-9 mg/kg/zi

SISOMICINA

3 mg/kg/zi (8,12,24 h)

3-5 mg/kg/zi

TOBRAMICINA

3-5 mg/kg/zi (8,12,24 h)

3 mg/kg/zi

KANAMICINA
STREPTOMICINA

15 mg/Kg/zi (12 h)
0,5-1 g/zi (24 h)

15 mg/kg/zi
30-50 mg/kg/zi

ISEPAMICINA

15 mg/kg/zi

CICLINELE
ANTIBIOTIC

DOZE ADULT

DOZE COPIL

PRIMA GENERAIE
TETRACICLIN

1-2 g (6 h), po

25-50 mg/kg/zi

OXITETRACICLIN
ROLITETRACICLIN

1-2 g (12 h), iv


300 mg, im

10-20 mg/kg/zi
-

LIMECICLIN

A 2-A GENERAIE
10-30 mg/kg (12 h)

10-15 mg/kg/zi

METACICLIN

10-30 mg/kg (12 h)


A 3-A GENERAIE

DOXICICLIN

200 mg (1 zi), apoi 100 mg

2-4 mg/kg/zi

MINOCICLIN

200 mg (1 zi), apoi 100 mg

2-4 mg/kg/zi

MACROLIDE
ANTIBIOTIC
ERITROMICINA
CLARITROMICINA
DIRITROMICINA
ROXITROMICINA

DOZE- ADULT
14 ATOMI C
2-3 g/zi, po
0,5 -2 g/zi, po
0,5 mg/zi, po
300 mg/zi

AZITROMICINA

15 ATOMI C: AZALIDE
500 mg/zi, po

10 mg/kg/zi

SPIRAMICINA
JOSAMICINA

16 ATOMI C
2-3 g/zi;4,5-9 mil UI/zi
1-2 g/zi

50.000 UI/kg/zi
30-50 mg/kg/zi

PRISTINAMICINA
VIRGINIAMICINA

SINERGISTINE
3 g/zi, po
3g

50-100 mg/kg
50-100 mg/zi

GLICOPEPTIDE
ANTIBIOTIC
VANCOMICINA
TEICOPLANIN
ORITAVANCIN
DALBAVANCIN

DOZE ADULT
1,5-2 g, iv (12 h)
200-400 mg/zi
(ncrcare: 12 mg/kg la 12 h x 3)
200 mg/zi

DOZE- COPIL

25-50 mg/kg/zi
5-8 mg/kg/zi

DOZE COPIL
0-30 zile: 15 mg/kg/zi
> 30 zile: 10 mg/kg/zi
3 mg/kg/zi

CLORAMFENICOL
< 28 zile: 12,5- 25 mg/kg la 6 h.
Copii mari i aduli: 50 mg/kg/zi (la 6 ore interval)
Copii mari i aduli cu meningit: 100 mg/kg/zi (la 6 h interval)

CLASIFICAREA BIOLOGICA A
QUINOLONELOR
GRUPA I : SPECTRU LIMITAT

CLASIFICAREA
MICROBIOLOGIC

ACID NALIDIXIC
ACID OXOLINIQUE
ACID PIROMEDIQUE
ACID PIPEMEDIQUE
FLUMEQUINE
CINOXACINE
GRUPA II : SPECTRU LARG
FLUOROQUINOLONE
PEFLOXACIN : 400 mg la 12 -24 h, iv, po
NORFLOXACIN: 400 mg la 12 h, po
CIPROFLOXACIN: 500-750 mg la 12h, iv, po
LOMEFLOXACIN: 400 mg/zi
OFLOXACIN: 200-400 mg la 12h, po
ENOXACIN
GRUPA III: SPECTRU EXTINS
FLUOROQUINOLONE
MOXIFLOXACINA: 400 mg la 24 h, iv, po
LEVOFLOXACINA: 250-500 mg la 24h, po
GEMIFLOXACINA: 320 mg la 24 h po
GATIFLOXACINA: 400-600 mg la 24 h, iv, po

Enterobacteriaceae

Enterobacteriaceae i H.influenzae
Neisseria spp.
Staphylococus coagulazo negativ
Patogeni intracelulari (Mycoplasma spp.)
P.aeruginosa
Acinetobacter spp.
Vibrio holerae
M.tuberculosis, M.leprae

Spectrul grupei II + S.pneumoniae


Streptococcus spp. +/- anaerobi

KETOLIDE: TELITROMICINA
Doz: 800 mg/zi (doz unic/zi)

OXAZOLIDINONE : LINEZOLID
Doz: 600 mg x2/zi sau 25 mg/kg/zi

METRONIDAZOL
Doza depinde de infecie
Giardiaz: 250 mg x2/zi, 5-7 zile, sau 2 g/zi, 3 zile
Infecii anaerobi:
i.v. 15 mg/kg apoi 7,5 mg/kg (administrare la 6 h)
p.o. 1-2 g/zi n 2-4 doze
I ALI NITROIMIDAZOLI (ORNIDAZOLUL, CARNIDAZOLUL I SECNIDAZOLUL)

SULFONAMIDE: SULFADIAZINA, SULFISOXAZOL, SULFAMETOXAZOL,


SULFADOXINA I TIMETOPRIM (trimetoprim 80 mg; sulfametoxazol 400 mg)

LIPOPEPTIDE: DAPTOMICINA
Infecii complicate ale pielii i esuturilor moi : 4 mg/kg/zi, iv, doz unic
Endocardite: 6 mg/kg/zi, iv.

GLICILCICLINE: TIGECICLINA

RIFAMICINE

POLIMIXINE: POLIMIXINA E COLISTINUL


Doza p.o. n infecii digestive cu Salmonella, Shigella: 100.000 UI/kg/zi la 6 ore
Doza i.m. : 50.000 UI/kg/zi
Doza i.v.: 30.000 UI/kg/zi

MONOBACTAM: AZTREONAM