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In pathology, a cardinal sign or cardinal symptom is the primary or major clinical sign symptom by
which a diagnosis is made.[1]
A cluster of signs or symptoms are often combined (pathognomonic) to better diagnose a specific
disease or syndrome.
Examples[edit]
Inflammation is characterized by five cardinal signs:[2]
rubor (redness),
calor (increased heat),
tumor (swelling),
dolor (pain), and
functio laesa (loss of function).
In acute exacerbations of chronic bronchitis, diagnosis is normally based on the three cardinal signs
of:[3]