By: Francis Gerald Scott T.

Gonzales

VIRAL CHARACTERISTICS
VIRION: Icosahedral capsid
Non-enveloped
28-30 nm in diameter
GENOME: (+) ssRNA
Non-segmented
Linear
7.2-8.4 kb
DIVISIONS: Group A, types 1-24 (there is no type 15, 18, & 23)
Group B, types 1-6

REPLICATION CYCLE
REPLICATION: Cytoplasm
ASSEMBLY: Cytoplasm
MATURATION: Cytoplasm
RELEASE: Cell Lysis

PATHOGENESIS
INCUBATION PERIOD: 2-9 days
TROPISM: Group A Oropharynx
GI tract
Skin & mucous membrane
Group B Heart
Pleura
Pancreas
Liver
ICAM-1 host cell receptor
TRANSMISSION: Fecal-oral
Respiratory droplet
Direct Contact
Ingestion (contaminated water)
DISEASES:
COXSACKIE VIRUS GROUP A
Herpangina
Hand-foot-and-mouth Disease (HFMD)
COXSACKIE VIRUS GROUP B
Pleurodynia
Infectious Myocarditis
Bornholm Disease
Infectious Pericarditis
Generalized disease of infants

LABORATORY DIAGNOSIS

DISEASES
Group A Herpangina (papules in pharynx, tounge,
palate, tonsils; sore throat; headache; pain in
abdomen, neck & extremities; convulsions; vomiting)
Group B Pleurodynia (inflammation of inter-costal
muscles & muscular attachment of diaphragm to chest
wall)

HERPANGINA

PCR (Polymerase chain reaction)

Immunofluorescence
ECG (Electrocardiogram)
ELISA (for IgM)
Cell Culture

HFMD