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  • Single Fiber Polymorphism in Skeletal Muscles: A Case Example From The Lobster Scott Medler

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    Anonymous hkWIKjoXFV
    12 vizualizări24 pagini
    medler

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    Medler

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    medler

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    © All Rights Reserved
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    12 vizualizări24 pagini

    Single Fiber Polymorphism in Skeletal Muscles: A Case Example From The Lobster Scott Medler

    Încărcat de

    Anonymous hkWIKjoXFV
    medler

    Drepturi de autor:

    © All Rights Reserved
    Descărcați ca PPT, PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    din 24

    SingleFiberPolymorphisminSkeletalMuscles:

    ACaseExamplefromtheLobster
    ScottMedler

    Wolfe,1985
    CellUltrastructure

    GuytonandHall1996
    TextbookofMedicalPhysiology
    9thEd.

    GuytonandHall1996
    TextbookofMedicalPhysiology
    9thEd.

    GuytonandHall1996
    TextbookofMedicalPhysiology
    9thEd.

    S1/S2MHCexpression

    Tmexpressionvs.MHCexpression(mRNA)

    TnT3proteinvs.S1/S2MHCmRNA

    TnI3proteinvs.S1/S2MHCmRNA

    TnI2proteinvs.S1/S2MHCmRNA

    CONTINUUM OF ISOFORM EXPRESSION


    S1 fibers

    = high expression

    = low expression

    S2 fibers

    S1 MHC
    S2 MHC
    TnT3
    TnT1
    TnI3
    TnI2
    S1 Tm

    S2 Tm

    ImmediateResearchFocus:
    Singlefiberpolymorphisminlobsters
    Developmentalchangesinfiberphenotype
    Mechanicalmeasurementsfromsinglefibers
    Innervationpatternandfiberphenotype
    Effectsofelectricalstimulationonfiberphenotype

    LongTermResearchInterests:
    SingleFiberPolymorphisminMammals
    ScalingEffectsonCellular/MolecularOrganizationofMuscles
    PhysiologyofAvianFlightMuscles

    Acknowledgements:
    NationalInstitutesofHealth:PostdoctoralfellowshipAR0859701A1toS.Medler
    NationalScienceFoundation:IBN0077422toD.L.Mykles
    Dr.D.L.MyklesColoradoStateUniversity
    TravisLilleyColoradoStateUniversity

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