Paramyxoviridae

Main features
PARAMYXOVIRIDAE
 Paramyxoviridae
enveloped ss –ve sense helical non-segmented RNA viruses

Para influenza RSV Measles Mumps

Meta pneumovirus

All initiate infection in RT

Remain limited to respiratory epithelium disseminate throughout the body and

produce generalized disease

Sub- Paramyxovirinae Pneumovirinae Paramyxovirin Paramyxovirinae

family ae

Genus Respirovirus Pneumovirus Morbillivirus Rubulavirus

& Rubulavirus
 Paramyxoviridae

Human Parainfluen Mumps Measles RSV

viruses za 1,3
parainfluen
za 2,4a,4b
Genus Respiroviru Rubulavirus Morbillivirus Pneumoviru
s s
Rubulavirus
Serotypes 5 1 1 2
1,2,3,4a,&
4b
F + + + ONLY F

Haemolysin NO
HAEMOLYIN
HA +2 +2 +3
NO HA
NO NA
NA +2 +2 NO NA
 Para Mumps Measles RSV
influenza
Transmission Droplet
Direct Ag: IF or Ag: IF or Ag IF or
detection ELISA ELISA ELISA
NA PCR NA PCR NA PCR

Isolation T.C.C Monkey or Monkey or T.C.C

CPE - PCR human human CPE- PCR-
IF kidney kidney IF
HA & HAD
Serology ------- HAI HAI ------
CF CF
NT NT
VACCINE ------ A live attenuated viral ----------
vaccine is available
 Para influenza Mumps Measles RSV

Infectio - Rhinitis Mumps Parotitis Measles + rash Under 1 year

ns of age It is
- Pharyngitis May infect: Complications: the main
& the testes and ovaries: Post-infectious cause of:
atrophy of the organs may
complic Laryngeotrache encephalitis
occur due to pressure
ations o-bronchitis necrosis and sterility may immune mediated, 

(croup) result. occurs after rash. Bronhiolitis

6-18 months 50% of
the kidneys Immunocompromi cases
z-ed patients with
The CNS measles may have
Broncholitis persistent 

& Pneumonia infection, Pneumonia

Pancreas
resulting in death. 25%
< 6 months Joints
-
Subacute
Complications: sclerosing
 Aseptic meningitis, panencephalitis
 (SSPE):
Meningoenchephalitis 7: 106
.
 polyarthritis,

 pancreatitis

 nerve deafness.
 Para influenza Mumps Measles RSV

Treatment mainly Symptomatic Symptomatic mainly

symptomatic No specific No specific symptomatic
antiviral agent antiviral agent
Ribavirin Ribavirin
aerosol in life aerosol in life
threatening threatening
infections infections

Immunity Re-infection Solid Solid Re- infection

common* common*

* Serum antibodies partially protective