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heterogeneity corrections. Pencil beam algorithm is proven effective for tumors located in
homogeneous regions with similar tissue consistency such as the brain. The limitation of PB
could be when computing the dose to the extra-cranial tumors such as in the lung, and head and
neck regions where large inhomogeneities exist.
References
1. Discussion with Joshua David Evans, Medical Physicist at the Virginia Commonwealth
University Health System Massey Cancer Center. March 30, 2015.