Nanomedicina si vaccinul terapeutic

n infecia cu virusul HIV

Cicala Ecaterina, an III

Cuvinte-cheie

Vaccin terapeutic

HIV-SIDA

Cuvinte-cheie

Terapie antiretroviral combinat

(cART combinated antiretroviral therapy)

Celule Langerhans, celule dendritice

Imunogenitate
pADN (plasmid ADN)
VLP (virus-like particle)

Vaccinul terapeutic pe baza

celulelor dendritice

Puncte slabe
1.Procedur laborioas
2.Durat
3.Risc

Nanoparticula

PEIm polietilenimin manoz

API active pharmaceutical

ingredient

Conceptul

Lisziewicz J, Bakare N, Calarota SA, Bnhegyi D, et al. (2012) Single DermaVir Immunization: Dose-Dependent Expansion of
Precursor/Memory T Cells against All HIV Antigens in HIV-1 Infected Individuals. PLoS ONE 7(5): e35416.
doi:10.1371/journal.pone.0035416
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035416

Puncte forte

+ reactii adverse minime

+ schem terapeutica simpl

Puncte slabe

Variabilitate viral
Variabilitate genetic a pacientului (rspunsul
imun)

Solutie

Tratament personalizat

Soft de prelucrare a datelor genetice si a tipului

HIV
Cost-eficient (?)

Bibliografie

1. Julianna Lisziewicz, PhD, Enik R. Tke, PhD, Nanomedicine applications

towards the cure of HIV, Nanomedicine: Nanotechnology, Biology, and Medicine 9
(2013) 2838, received 10 February 2012; accepted 16 May 2012
2. Gh.Coman, M.Badea, N.Bigiu, A.Vlceanu Matei, Biochimie Clinic.
Enzimologie, Ed.Univ.Transilv. din Braov, 2012

3. Fauci, Braunwals, Isselbacher, Wilson, Martin, Kasper, Hauser, Lougo Principii

de Medicin Intern a lui Harrison, Ediia a XIV-a, Ed. Teora, Bucureti, 2003

4. Arthur C. Guyton, John E. Hall, Tratat de Fiziologie a Omului, Ediia a XI-a,

Editura Medical Callisto, 2007

5. I. Fulga Farmacologie, Editura Medicala, 2006

6. Julianna Lisziewicz, PhD, DermaVir Immunotherapy Towards HIV Eradication,

geneticimmunity.com, December 6, 2012