PATOFISIOLOGI

Virus oncogenic
Endogen factor
Exogen factor

ALL

Over production of WBC

Competition fo nutrients

infiltration

Generalized hypermetabolism

Cellular
Starvation

weight loss

GI tract

hepatosplenomegali

Altered nutrition less

than body requirement

CNS

bone marrow

mouth ulceration, lympe nodus

increase fluid/
monilia & esofagus
intracranial pressure

anorexia

decrease RBC

anemia

altered perfussion

Involvement on cranial nerve

severe headache
(N.VII,spinal nerve,lumbosacral nerve,
hippothallamus,cerrebellum)

vomiting

papil edema

iritability

lethargi

decrease WBC

risk infection

fatique

meningen iritation

decrease platelets increase pressure

risk injury

bone & joint thining & weakening of bone

pain

pathologic fracture