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  • Iron Review

    Încărcat de

    alobrien
    7 vizualizări2 pagini
    iron metabolism

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    iron metabolism

    Drepturi de autor:

    © All Rights Reserved
    Descărcați ca DOCX, PDF sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    7 vizualizări2 pagini

    Iron Review

    Încărcat de

    alobrien
    iron metabolism

    Drepturi de autor:

    © All Rights Reserved
    Descărcați ca DOCX, PDF sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    din 2
    Ferrop2t Fee Liver Macropnage Biooa Hephaestin Plasma ° veanstorin Must be Fe®* to reabsoro Corulopiasmin Enytroid Lost by shedding of epithelial cels ‘Sensor LTranstetin ion (oss ron attached to tranetertin ‘Ttranserption of epcicin > J nepcicin => * iron eabsorption in uodenum and release of on rom macrophages: “Transterin receptor {TTranstertin ito (more ron attached to transfer: Transterrin with Fo? ‘7 Transerption of hepeidin > T hepclain “> «ron reabsorpion in duodenum and release of Fon rom macrophages. 12.8: iron absorption. The reabsorption of iron is dependent on total iron stores in the body, which i reflected in the amount of iron that iz bound to transferrin. Transferrin with iron binds to immature precursor cells of Normal enterocytes, which serve as ron sensors in the duodenum. The HFE hemochromatosis gene (HFE gene) Protein product in these sensor cels acting together with the transferrin receptor causes the precursor cells 0 Gifferentiate into mature enterocytes that can actively reabsorb iron. Absorptvely active enterocytes absorb ‘ferrous iron (Fe") directly via heme carrier protein 1 or through the divalent metal transporter (OMT), Absorbed itan i ether stored in the cytoplasm as mucosal ferritin or Wansferred to the ferroporin 1 port where itis con verted to ferric iron (Fe") by hephaestin and ceruloplasmin. Plasma transferrin then binds the iron and carries it ‘0 erythroid precursors in the bane marrow. The HFE protein also regulates the production of another protein

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