RECONSTITUTION

GENERIC
NAME
Actinomycin D
(Dactinomycin)

TRADE
NAME
COSMEGEN
500 mcg.

Bleomycin

BLEOCIN 15 mg.

Carboplatin

CARBOPLATIN
150 mg./15 ml
CARBOPLATIN
450 mg./45 ml
PARAPLATIN
150 mg/15 ml.
PARAPLATIN
450 mg/45 ml.

DILUENT
- SWFI 1.1
ml

- IV-SWFI
5.2 ml.
- SC/IM-NSS
5.2 ml

PREPARATION
FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
0.5 mg / ml
- 2-5 mth.- - D5W / NSS
RT
- 10% loss
was observed
when 9.8 mg/l
D5W
3 Unit / ml
- 14 d.-RT - 50 ml NSS
( 3 mg / ml )
- 30 d.-Ref - 1 unit (0.33)
test dose in
50 ml NS
10 mg / ml

- 30 d.-Ref - 250 ml D5W

INFUSION
TIME

STABILITY

COMPATIBILITY

- 24 hrs.-RT

7 d. Ref.

60 min

- In D5W :
7 d. - Ref
- In NSS :
24 hr - RT

COMMENTS
- Protect from
light and
humidity

Incompatible :
- Furosemide
- Methotrexate

- Deduct test
dose from
total dose.

Incompatible :
- Mesna

GENERIC
NAME
Cisplatin

Cyclophosphamide

TRADE
NAME
KEMOPLAT
10 mg./20 ml.
KEMOPLAT
50 mg./100 ml

DILUENT

ENDOXAN
- 1000 mg
200 mg
50 ml
ENDOXAN 1 g.
SWFI
CYCLOXAN
( shake
200 mg.
vigorously to
CYCLOXAN 1 g. dissolve )
- 200 mgSWFI 10 ml
- 500 mgSWFI 25 ml

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
1 mg / ml
- 7 d.-RT - 50-1000 ml
NS and 1/3
NS-2/3 D5W

20 mg / ml

- 14 d.-Ref - 50 ml
D5W / NS

INFUSION
TIME
1 mg / min
or as per
protocol

15-30 min.

STABILITY

COMPATIBILITY

COMMENTS

- 7 d. - RT
Incompatible :
- Do not
- 3 d.- RT
- Fluorouracil
refrigerate
(when mixed - Metoclopramide - Protect
with mannitol)
from
direct light
- May be
mixed with
mannitol
- 7 d. Ref
- 24 hr RT
(NTUH)

GENERIC
NAME

TRADE
NAME

DILUENT

FINAL
STABILITY
CONCENTRATION

INFUSION
SOLUTION

Cytarabine

CYTOSAR
100 mg.

- SWFI 5 ml

20 mg / ml

- 14 d.-RT - Bolus 50 ml
D5W / NSS
- 3-6 hr Inf.
250 ml
D5W / NSS
- 24 hr Inf.
1000 ml
D5W / NSS

Docetaxel

TAXOTERE
20 mg.
TAXOTERE
80 mg.

- Add entire
diluent
provided

10 mg / ml

- 4 hrs
RT / Ref

- 250 ml
D5W / NSS

INFUSION
TIME

STABILITY

15 min
- 7 d. Ref
(low dose)
3-6 hrs
(high dose)
1000 mg/m2

1 hr

- 4 hr.-Ref/RT

COMPATIBILITY

COMMONTS

Incompatible :
- For
- Fluorouracil
Interthecal
- Heparin
Injection, use
- Hydrocortisone a new 100
sodium
mg/ml 1 ml
succinate
size vial.
Discard after
Use.
- Warm vial @
RT prior to
mixing-do
not shake
- Irritant

GENERIC
NAME
Doxorubicin

TRADE
NAME
-

DoXorubicin
(Liposomal)

Epirubicin

DILUENT

ADRIBLASTINA
RD 10 mg
ADRIBLASTINA
RD 50 mg
DOXORUBICIN
HC SOL
10 mg/5 ml.
DOXORUBICIN
HC SOL
50 mg/25 ml.
CAELYX 20 mg
LIPO-DOX
20 mg / 10 ml

- 10 mg SWFI
5 ml
- 50 mg SWFI
25 ml.

FARMORUBICIN
10 mg.
FARMORUBICIN
50 mg.

- SWFI 5 ml.
- SWFI 25 ml

FINAL
STABILITY
CONCENTRATION

INFUSION
SOLUTION

2 mg / ml

- 30 d.-Ref - 50 ml
D5W / NSS

20 mg / ml

- 24 hr.Ref

2 mg / ml

- 30 d.-Ref - 50 ml NS

INFUSION
TIME
15 min

- 250 ml D5W

15 min

STABILITY

COMPATIBILITY

COMMONTS

- 24 hr.-RT
- 48 hr.-Ref

- Vesicant
- Protect from
light

- 24 hr.- Ref

- Irritant
- Protect from
light
- Do not
freez
- Vesicant

- 7 d. - Ref

GENERIC
NAME
Etoposide

Fluorouracil

TRADE
NAME
FYTOSID
100 mg./5 ml.

FLUOROURACIL
250 mg./5 ml.
FLUOROURACIL
ABIC 500 mg./
10 ml.

DILUENT

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
20 mg / ml
- 7 d.- NS to a
RT / Ref concentration
of 0.4 mg/ml
or less ( 500
ml )
50 mg / ml
- 7 d.-RT - Bolus50 ml
D5W / NSS
- Inf-1000 ml
D5W / NSS

INFUSION
TIME
60 min

15 min
24 hrs

STABILITY
- 24 hrs if less
than 0.4
mg/ml
Ref / RT
- 7 d. - RT

COMPATIBILITY

COMMENTS
- Irritant

Incompatible :
- May be give
- Do not infuse
direct IV
with any other
drugs including
acidic drugs,
Cisplatin ,
Cytarabine,
Doxorubicin,
Droperidol

GENERIC
NAME
Gemcitabine

Idarubicin

Ifosamide

Irinotecan

TRADE
NAME
GEMZAR
200 mg.
GEMZAR 1 g.

DILUENT
- 200 mg
5 ml NSS
- 1000 mg
25 ml NSS

ZAVEDOS 5 mg. - 10 mg ZAVEDOS 10 mg. WFI10ml

HOLOXAN
- SWFI
1000 mg.
25 ml

CAMPTO 100 mg.

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
40 mg / ml
- 7 d.-RT - 250 ml NSS

1 mg / ml

- 3 d.-RT
- 7 d.-Ref

40 mg / ml

- 7 d.-RT - NSS/D5W to
- 30 d.-Ref concentration
of 20 mg/ml
( 500 ml )
- 30 d.-Ref - 500 ml D5W
(NSS not
recomment)

20 mg / ml

- 50 ml
NSS / D5W

INFUSION
TIME
30 min

- 7 d.-Ref / RT

10-15 min

- 7 d. - Ref

1-3 hrs

- 7 d. - Ref

90 min

- 48 hrs - Ref

STABILITY

COMPATIBILITY

COMMENTS

- Reconstitute
- Stability
with 5 ml WFI to data from
give a conc. 1
Lilly in
mg/ml. Gently
house study
swirl to mix.
- Add the dose to
100 ml N/S. Mix
by squeezing
bag. Avoid
foaming
- Vesicant
Incompatible :
- Methotrexate

- Compactible
with Mesna

- Not
compatible
with NSS.
- Protect
from light

GENERIC
NAME
Methotrexate

TRADE
NAME
-

DILUENT

ZEXATE 50 mg.

NOTE :
2 STRENGTHS

Mitomycin

FINAL
STABILITY
CONCENTRATION

25 mg / ml

Mitomycin C
2 mg
Mitomycin C
10 mg

- 40 mg +
SWFI
20 ml
( CA
Bladder )

1 mg / ml or
2 mg / ml
(Do not refrigerate)

INFUSION
SOLUTION

- Discard - Bolus50 ml
ml vial
D5W / NS
after use - Infusion
- 30 d.-Ref 250-1000 ml
D5W / NS

- 14 d.-Ref
(NTUH)
- 7 d.- RT
or 14 d.Ref

INFUSION
TIME
15 min

- 14 d.-Ref or
7 d.- RT
(NTUH)

STABILITY
- 36 hrs Ref / RT

COMPATIBILITY

COMMONTS

Incompatible :
- For I.T.
- Do not infuse
use preswith any other
free Adults :
drugs including qs to 4 ml
Heparin,
with NS.
Bleomycin,
Pediatrics :
Metoclopramide qs to 3 ml
with NS
- May be
mixed with
hydrocortisone or
cytarabine
for I.T.
- For intervesical
qs. To 50 ml
with NSS and
transfer tip
syringe
- vesicant

GENERIC
NAME
Mitoxantron

TRADE
NAME
MITOXANTRONE
ASTA 20 mg./
10 ml.

DILUENT

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
2 mg / ml
- 30 d.-Ref - 50 ml
NSS / D5W

Oxaliplatin

ELOXATIN 50 mg. - 50 mg vial

Oxalip 50 mg
SWFI10ml

5 mg / ml

- 48 hrs RT / Ref

Paclitaxel

ANZATAX
150 mg./25 ml.
ANZATAX
30 mg./5 ml.
TAXOL 100 mg/
16.7 ml.
TAXOL 30 mg/
5 ml.

6 mg / ml

- 30 d.-Ref - 500-1000 ml
D5W (nonPVC
Container)
To final
Conc Of
0.3-1.2
mg/ml

- 250-500 ml
D5W
(Do not use
normal saline)

INFUSION
TIME

STABILITY
- 7 d. - Ref

- 48 hrs Ref

- 48 hrs - Ref

COMPATIBILITY

COMMONTS

Incompatible :
- Vesicant
- Do not infuse
with any other
drugs including
Heparin
- Flus line
with D5W
after
oxaliplatin
before other
drug.
- Requires
admin via
0.22 filter
- Irritant

GENERIC
NAME
Topotecan

Vinblastine

Vincristine

Vinorelbine

TRADE
NAME
HYCAMTIN 4 mg.

VINBLASTIN
10 mg.
VINCRISTINE RX
1 mg.
NAVELBINE
10 mg
NAVELBINE
50 mg

DILUENT
- SWFI
4 ml
- SWFI 10 ml

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
1 mg / ml
- 24 hrs- - 100 ml
Ref
NSS / D5W
1 mg / ml
1 mg / ml
10 mg / ml

- 30 d.-Ref - Bolus50 ml
D5W / NS
- 30 d.-Ref - 50 ml
D5W / NS
- 30 d.-Ref - 50 ml D5W

INFUSION
TIME

STABILITY

COMPATIBILITY

COMMONTS

15 min

- 7 d.-Ref
- 24 hrs- Ref
(BC CANCER)
- 7 d. - Ref

- Vesicant

15 min

- 7 d. - Ref

- Vesicant

6-10 min

- 7 d. - Ref

- Vesicant
- Admin.
Into port
of a free
flowing IV

ADJUVANT MEDICINE
GENERIC
NAME
Basiliximab

Daclizumab

Leucovorin Ca

Trastuzumab

Zoledronic acid

TRADE
DILUENT
NAME
SIMULECT 20 mg. - SWFI 5 ml

ZENAPAX
25 mg/5 ml.
LEUCORORIN
50 mg.
RESCOVOLIN
15 mg
HERCEPTIN
440 mg.

Zometa

FINAL
INFUSION
STABILITY
CONCENTRATION
SOLUTION
4 mg / ml
- 4 hr.-RT - 50 ml D5W /
- 24 hr.NSS
Ref
5 mg / ml
- 50 ml NSS
10 mg / ml

- 30 d.-Ref - 50 ml
NSS / D5W

- 20 ml
diluent
provided

21 mg / ml

- 28 d.-Ref - 250 ml NSS

(
Dextrose
solution)

- 4 mg
SWFI 5 ml

0.8 mg / ml

- 24 hr.Ref

- 100 ml NSS
- 100 ml D5W

INFUSION
TIME
2 hr.

15 min.

STABILITY

COMMONTS
- Do not
shake

- 4 hr.-RT
- 24 hr.- Ref
- 4 d. Ref

- 24 hrs Ref
- 28 d. Ref
(NTUH)

15 min.

COMPATIBILITY

- 24 hrs Ref

- Do not
shake
- Non cytotoxic

- Reconstitute
- Do not
each 150 mg
give as IV
vial with 7 ml
push or
WFI to give a
bolus
conc. 22
mg/ml. Add
calculated dose
to 250 ml N/S.
DO NOT SHAKE
- Refrigerate

10

11