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CYTOPLASME

MITOCHONDRIE

enzyme malique

Acides gras

-oxydation

OAA malate pyruvate+NADPH

oxaloacetate

Citrate

Citrate

Citrate lyase

(2) Acetyl CoA


(2) Acetyl CoA

Thiolase

Thiolase

Acetoacetyl CoA

HMG CoA synthase

Acetoacetyl CoA
HMG-CoA
synthase

HMG CoA
HMG CoA lyase
Acetoacetate

cytoplasme

HMG CoA
-Hydroxybutyrate

HMG CoA
reductase

CORPS CETONIQUES
(dans le foie )

reticulum
endoplasmic

Mevalonate
CHOLESTEROL
93

;" 4

-")!

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ACAT: acyl CoA:cholesterol acyltransferase


O
||
O
R-CS-CoA
||
A CAT (pour tre stocker
O
O
dans les cellules)
O
R-C
||
||
Acyl CoA
||
R-C
R-C
HO
R-CO
O O OO
|| ||
|| ||
Cholesterol
R-COlibre R-CR-C R-C
P-choline LCAT
Lecithin (pour tre transporter par le
HDL)

LCAT: lecithin:cholesterol acyltransferase

Esterification du Cholesterol

O
||
R-C-O
Cholesterol
esterifi

12

12
( .

!2(
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