Documente Academic
Documente Profesional
Documente Cultură
Transmiterea i procesarea
semnalului n sistemul nervos
Repere istorice
L.Galvani 1791- 97-electricitatea
animal
A.Volta-bateria electric
J.Bernstein- potential bioelectric
Ch. Sherrington 1897- Sinapsa
Cole i Curtis -1939, Hodkin&Katz
Hodkin & Katz- 1949- PA / Na
Otto Loewi-1920- Ach
Componenta trigger
trigger si de conducere
Transmiterea i procesarea
semnalului n sistemul nervos
I. Transmiterea sinaptic
Transmiterea sinaptic electric
Transmiterea sinaptic chimic
Transmiterea sinaptic gazoas
Transmitere efaptic
Transmiterea i procesarea
semnalului n sistemul nervos
Transmiterea sinaptic chimic
Enzime
Activitate
Acetil colin
Colin acetiltransferaz
Specific
Dopamin
Tirozin hidroxilaz
Specific
Epinefrin
Tirozin hidroxilaz i
dopamin b hidroxilaz
Norepinefrin
Tirozin hidroxilaz i
dopamin b hidroxilaz
Specific
Serotonin
Triptofan hidroxilaz
Specific
Histamin
Histidin decarboxilaz
Specificitate incert
Amine biogene
Aminoacizi
GABA
Glutamat
Enzime din
metabolismul general
Cale specific
nedeterminat
Glicin
Enzime din
metabolismul general
Cale specific
nedeterminat
Peptide
Vasopresin, Oxitocin
Peptide hipofizare
ACTH, BB-endorfin, A
A--MSH, Prolactin,
LH, GH, TSH
Peptide gastrointestinale
Peptide cardiace
ANF
Altele
Sinapsa chimic
Segment
presinaptic
AGONITI
ANTAGONITI
Sinaps excitatorie
Sinaps inhibitorie
Segment
postsinaptic
sinapsa colinergic
Receptori colinergici
Nicotinici
Ag.nicotina
Atg. d-tubocurarina
Muscarinici
Ag.muscarina, pilocarpina
Atg. atropina
Nicotinici musculari
Nicotinici neuronali
Ag.oxotremorina
Ag.feniltrimetilamoniu Ag.dimetilfenilpiperazina
Atg. propilbenzilcolina
Atg. d-tubocurarina
citisina
Atg. trimetafan, bungarotoxin
embrionar
(1)2
jonctional
(1)2
nicotinici
neuronali
2-5
nicotinici
neuronali
2-10
muscarinici
M1-5
R. MUSCARINICI
Muscarinici M1
pirenzepin
Muscarinici M2
metoctramin
Muscarinici M3
hexahidrosiladifenidol
Muscarinici M4
himbacin
Muscarinici M5
?
Sinapsa Colinergica
Transportor
de colina
Transportor
vezicular ACh
ACh
ACh
Muscarinici
atropina
Nicotinici musc.
D-tubocurarina
Nicotinici nn.
hexametoniu
vesamicol
ChAT
Colina
ACh
Muscarinici
carbachol
edrofoniu
Nicotinici musc.
suxametoniu
Nicotinici nn.
lobelina
AcCoA
M.Gravis ?
AChE
ACh
fizostigmina
hemicolinium
Colina + Ac-
-AdrR
M2/M4
mAChR
AC
ATP
GTP
cAMP
GTP
M(1,3,5)
mAChR
PI-PLC
Protein
kinazaC
q/11
PIP2PIPPI
Ca2+
GTP
Diacilglicerol
IP3
sinapsa adrenergic
inim, ficat,
cerebellum,
cortex cerebral,
vase sanguine
1B
515
5
Ca2+, PKC
1D
560
20
Ca2+, PKC
2B
Aminoacizi
450
450
Cromosom
10
2
Cale efectoare cAMP
cAMP
Distribution
pancreas,
ficat,
intestin subire, talamus
locus ceruleus
hipocampus
2C
461
4
cAMP
inim,plmn
aorta, hipocampus
bulb olfactiv,
Aminoacizi
477
413
Cromosom
10
Cale efectoare
cAMP
cAMP
Distributie
3
402/408
8
cAMP
inim, rinichi,
plmn,ficat
creier,
cortex cerebral, cerebellum,
esut adipos
hipotalamus
hipocampus,
cortex cerebral,
muschi neted,
bulb olfactiv
Fenotip
Receptor adrenergic 1A
Receptor adrenergic 1B
Receptor adrenergic 1D
Receptor adrenergic 2A
Receptor adrenergic 2B
Receptor adrenergic 2C
Fr un fenotip evident
Receptor adrenergic 1
Receptor adrenergic 2
Receptor adrenergic 3
Sinapsa noradrenergica
Sinapsa glutamatergica
Transmiterea i procesarea
semnalului n sistemul nervos
Transmiterea nonsinaptic