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Unprotected sex
Skin cuts
Needle pricks / i. v. drugs
Mother to baby etc
Time is Life…. Only 72 hours
PEP is unlikely to work after 72 hours (3 days) of
exposure
* Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health-care workers after percutaneous exposure. N Engl
J Med 1997;337:1485-90 .
How does PEP work ?
Pathogenically, there is time lag between
HIV exposure, viral seeding, replication and
systemic infection
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