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Model Paper
Biochemistry
BIOCHEMISTRY
Please use a dark pencil/pen to complete the test. Read the instructions at the
begining carefully. This is a practice test series in Biochemistry.
Please Note: There is a Negative Marking of (-1) for each incorrect response.
1. Given below is a list of Vitamins:
(i) Cholecalciferol (iii) Riboflavin (v) Niacin
(ii) Vitamin B12
(iv) Folic acid (vi) Pyridoxine
Which of the above given vitamins are involved in energy-releasing functions?
A (iii),(vi)
C (ii),(iii),(v),(vi)
B (iii),(v)
D (v),(vi)
C Vit. B6
B Vit. B2
D Vit. B1
C Cytosol
B Mitochondria
D Microsomes
C aminoimidazole carboxamide
B pyridine-3-carboxamide
D N'-methyl-2-pyridone-5-carboxamide
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Series I-C
Model Paper
Biochemistry
C folylpoly--glutamyl synthase
D 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate
B P-aminobenzoic acid
7. Fill in the blanks:
Amino acid1 + E-PLP
[A]_______________ + E-PMP
C 5-methyl-H4PteGlun
B N'-methylnicotinamide
D N-methyl-2-pyridone-5-carboxamide
C Niacin
B Biotin
D Thiamine
C tryptophan
B dihydroacetone phosphate
D tyrosine
C Cysteine
B Methionine
D Histidine
C pregnancy
B rheumatic fever
D rheumatoid arthritis
13. Match the following amino acids according to their corresponding polarity and
charge:
A.
B.
C.
D.
E.
Proline
Valine
Glutamine
Glutamate
Arginine
A.
B.
C.
D.
E.
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Series I-C
Model Paper
Biochemistry
D identification of C terminal
residue
15. To fragment polypeptide chains, the reagent used at cleavage point Phe, Trp, Tyr
at N terminal is:
A Trypsin (porcine stomach)
C Anthranilic acid
B Histamine
D Kynurenic acid
C Bacitracin
B Vancomycin
D Methicillin
C 3-hydroxy-anthralinate
B Kynurenine
D acetoacetate
19. Rearrange the following urea cycle intermediates according to their correct order
of formation:
A.
B.
C.
D.
Arginine
Argininosuccinate
Carbamoyl phosphate
Ornithine
E.
Citrulline
C Valine
B Leucine
D Tryptophan
C pyridoxine-5'-phosphate
B pyridoxal-5'-phosphate
D histidine decarboxylase
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Series I-C
Model Paper
Biochemistry
C Spermidine
B Cadaverine
D Ornithine
C Renin
B Chymotrypsin
D Pepsin
Ornithine decarboxylase
Aromatic L-amino acid
decaboxylase
Polyamine oxidase
A. formation of histamine
B. spermine to putrescine
C. formation of L-Dopa
D.
E.
Tyrosine hydroxylase
Dopamine -oxidase
D. formation of norepinephrine
E. polyamine biosynthesis
C Kala-azar
B Yellow fever
D Dengue
26. Which of the following is a sulphur containing amino acid that contains a
disulphide bond (-S-S-)?
A Serine
C Cysteine
B Methionine
D Cystine
C Tryptophan
B Tyrosine
D Phenylalanine
29. Nanogram concentration of amino acids can be detected by using which of the
following reagents?
A Ninhydrin
C Fluorodinitrobenzene (FDNB)
B Fluorescamine
D Dansyl chloride
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Series I-C
Model Paper
Biochemistry
C Glucocorticoids
B somatostatin
D propylthiouracil
31. The site of entry of threonine into TCA cycle for formation of glucose:
A Succinyl-CoA
C -ketoglutarate
B Pyruvate
D Oxaloacetate
C Penicillin
B Streptomycin
D Trimethoprim
C reptiles
B birds
D bony fishes
35. During urea biosynthesis in humans, carbamoyl phosphate donates its carbamoyl
groups to:
A Citrulline
C Argininosuccinate
B Ornithine
D Urea
C 5-hydroxylysine
B 4-hydroxyproline
C Thiamine
B Folic acid
D Pyridoxine
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Series I-C
Model Paper
Biochemistry
C Plasmin
B 1-AT (antitrypsin)
39. Drug that is given to prevent thrombosis in patients who are prone to develop clots:
A Dicoumarol
C Desmopressin
B Vitamin K
D Ethamsylate
C Antithrombin III
B Thrombin
D Plasmin
Ehlers-Danlos syndrome
B.
C.
D.
E.
Osteogenesis imperfecta
Rotor syndrome
Alport syndrome
Stickler syndrome
A. chronic conjugated
hyperbilirubinemia
B. loose joints
C. abnormal fragility and bone formation
D. degeneration of joint cartilage
E. end-stage renal disease
42. A child diagnosed with homocystinuria has mental retardation and faulty
development of bones. The biochemical basis of this disease is due to defective
enzymeA Kynureninase
B Homoserine deaminase
D Cystathionine -synthase
C Kynureninase
B -ketoacid decarboxylase
D Kynurenine formylase
C phenyllactate
B p-hydroxyphenyllactate
D phenylacetylglutamine
C tyrosine decarboxylase
B tyrosinase
D dopa decarboxylase
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Series I-C
Model Paper
Biochemistry
C nephrocalcinosis
D hyperphosphataemia
B hypophosphataemia
47. Which vitamin acts as a coenzyme for reaction that yields methionine from
homocysteine?
A Biotin
C Pyridoxine
B Thiamine
D Cobalamin
48. A drug that inhibits monoamine oxidase thus prolonging the action of serotonin:
A iproniazid
C prazosin
B imipramine
D fluoxetine
49. Which of the following compound is essential for growth and differentiation of
epithelial cells?
A Retinol
C Retinoic acid
B Retinal
D Retinyl palmitate
C disulphide linkages
B hydrogen bonding
D proline residues
52. Which of the following statements about -Aminobutyric acid (GABA) is/are not
true?
A is formed by decarboxylation of
glutamate
D is an excitatory neurotransmitter
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Series I-C
Model Paper
Biochemistry
C lactate dehydrogenase
B pyruvate decarboxylase
D pyruvate carboxylase
C aldehyde dehydrogenase
B malate dehydrogenase
D D--hydroxybutyrate
dehydrogenase
C a reversible reaction
D source of acetyl CoA for Krebs
cycle
C glutamate
B Ornithine
D Carbamoyl phosphate
C Chymotrypsin
B Aminopeptidase
D Enteropeptidase
59. Regarding binding of DNA around histone, spot the incorrect statement(s):
A Unbound negative supercoil is
plectonemic
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Series I-C
Model Paper
Biochemistry
Fibrinogen
Fibrin clot
Prothrombin
Ornithine transamination
Glutamate transamination
A.
B.
C.
D.
E.
C Pantothenic acid
B Thiamine
D Niacin
62. Amino acid that is unable to furnish carbon for glucose synthesis
(nonglucogenic/nonketogenic):
A Leucine
C Isoleucine
B Cysteine
D Tyrosine
63. Which one of the following functions as lubricants in synovial fluid of joints?
A Chondroitin sulphate
C Heparan sulphate
B Hyaluronic acid
D Keratan sulphate
C urea
B glutamine
D uric acid
C citrulline
B hydroxyproline
D selenocysteine
C Proline
B Histidine
D Arginine
C (iii),(v),(vi)
B (iv),(v),(vi)
D (i),(iii),(vi)
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Series I-C
Model Paper
Biochemistry
C 3 and 4
B 1 and 3
D 2 and 3
C phosphoglucomutase
B Hexokinase
D Glucokinase
C pyruvate dehydrogenase
B pyruvate carboxylase
C Ascorbic acid
B Nicotinic acid
D Pantothenic acid
73. All of the following statements regarding triiodothyronine (T3) are incorrect except:
A deiodinase D3 is the main source
of T3 in the blood
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Series I-C
Model Paper
Biochemistry
C iodinase
B iodotyrosine deiodinase
D Both a & c
C epinephrine
B melanin
D serotonin
76. Which of the following is the best source of ascorbic acid (Vit.C)?
A Currant, black
C Brussels, sprout
B Rose hips
D Parsley
C asparagine
B asparaginase
D arginase
C Serine
B Phenylalanine
D Tyrosine
C 8-25 mg
B 4.5 gm
D 7.5 mg
D Argininosuccinase
C Calcitonin
D 1,25-dihydroxyvitamin D
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Series I-C
Model Paper
Biochemistry
C Uronic acid
B Amino sugars
D Hexosamines
C 0.7, 0.8
B 0.7, 1
D 0.8, 0.7
C Graves' disease
B Fever
D Myxedema
B metabolic acidosis
D Conn's syndrome
C 125 ml/min
B 100 ml/min
D 225 ml/min
88. Net effect of Parathyroid hormone (PTH) on bone and kidney is:
A increases ECF calcium
concentration
C Apoferritin
B Ceruloplasmin
D Siderophyllin
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Series I-C
Model Paper
Biochemistry
90. Most of the filtered load of phosphate (about 80%) is reabsorbed from the:
A proximal tubule
B distal tubule
D Loop of Henle
C Metabolic acidosis
B Respiratory acidosis
D Metabolic alkalosis
C calcium carbonate
B sodium phosphate
D Diisopropyl-fluoro-phoshate
C 60 nmol/l
B 57 nmol/l
D 40 nmol/l
94. Regarding conversion of CO2 into HCO3- in erythrocytes catalyzed by the enzyme
carbonic anhydrase, which of the following acts as a substrate(s)?
A Sunlight
C Glucose
B H2O
D H2CO3-
C 68,000
B 16,890
D 64,000
C carbonic anhydrase
B alcohol dehydrogenase
D succinate dehydrogenase
C hemosiderin
B transferrin
D ceruloplasmin
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Series I-C
Model Paper
Biochemistry
C metabolic alkalosis
B malabsorption
D alcohol abuse
100. Pick the correct pathway of hemoglobin degradation from the given below:
A Heme -> hb -> biliverdin ->
bilirubin -> stercobilinogen ->
urobilinogen
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Series I-C
Model Paper
Biochemistry
Disclaimer: Every attempt has been made to validate each and every
question/answers. Any remaining error is regretted. Author will not be held responsible
for any errors. Please consult standard textbooks given in the reference section for any
discrepancy. Questions with wrong answers may better be left unattempted/
unanswered. This is a practice MCQ series in Biochemistry available free to download
designed for the benefit of prospective PG candidates and UG medical students.
Reference Textbooks:
1. Principles of Biochemistry, Lehninger 4th Edition
2. Stryer Biochemistry, 5th Edition, Berg, Tymoczko and Stryer
3. Lippincott's Illustrated Reviews: Biochemistry, Harvey & Ferrier, 5th Edition
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