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Review Questions: Nerve muscle physiology

1. Draw a neat labelled diagram of a nerve action potential.


2. Explain the ionic basis of the different phases of an action potential
3. Explain the following terms with respect to nerve fibers
a. All or none law
b. Absolute refractory period
c. Relative refractory period
4. Classify nerve fibres as proposed by Erlanger and Gasser.
5. List three factors that affect nerve conduction velocity
6. Draw a neat labelled diagram of a skeletal muscle sarcomere
7. Explain briefly the sliding filament theory of muscle contraction
8. List the four key steps in cross-bridge cycling in skeletal muscle
9. Draw a flow chart showing the steps of excitation-contraction coupling
10. Discuss the role of Calcium and ATP in skeletal muscle contraction
11. Draw a neat labelled diagram of a neuromuscular junction.
12. Draw a flow chart depicting the steps of neuromuscular transmission
13. Explain the physiological basis of easy fatigability in myasthenia gravis and its
pharmacological management.
14. List two pre-synaptic and two post-synaptic neuromuscular blockers

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