Foam Granulation part 3

A report at pilot-scale flow rates compared foamed-binder addition and direct liquid-injection on
granulation. A methylcellulose binder was applied at two concentrations, 6% and 11%, in accordance
with a-lactose monohydrate powder. Two screws were tested in the work to produce differing axial
compression attributes with changing flow pace: one with a single couple of mixing components
generating lower axial compression and a second with two pairs in series to provide a far more
restrictive flow way and higher axial compression. The granule properties from the study showed
that similar sizes and intragranular porosity were achieved by either method, provided appropriate
circumstances were used. The decreased requirement for liquid along the way was a similar finding
compared to that found with high-shear batch mixers.
plastic extruder machine
Wet granulation in twin screw extrusion machinery has several key positive aspects over
conventional strategies, but to advance found in acceptance for GMP production, its operations
ought to be better comprehended and challenges regarding process stableness must be solved.
Continuous foam granulation is a fresh, robust approach that solves the procedure surging concerns
that relate with poor powder wetting by conventional, liquid-addition methods. The large spreading
tendency of foam in granulation, versus the instant soaking aspect of liquids, produces even more
uniformly wetted powders and escalates the overall lubricity of the procedure, which benefits be
dressed in behavior of the minimizes and machine dissipative heating of the product. With
comparable particle homes to standard wet granulation, foam granulation gives formulators higher
flexibility in achieving production goals.