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TABLE OF CONTENTS
Preface
04
Introduction
08
14
25
31
37
40
49
56
References
61
PREFACE
PREFACE
For years, nicotine was little more to me then an object of scientific
curiosity. It was something to study. Id come across it from time
to time in fat loss and muscle building articles and studies, and I
certainly found some of the research thats been done intriguing, but
its never been an emotionally charged issue for me. Nothing scientific is, nor should it ever be, unless were talking about the euphoria
associated with a new discovery or a hypothesis thats just been
proven.
It wasnt until I tried to publish my own findings on nicotine in the
media, however, that it really piqued my interest and made me want
to do more. Nobody wanted to touch the subject, which is the sort
of truth avoidance that compels me to write longer books like Carb
Back-Loading and reports like this one: The idea that theres something out there that can help us get the bodies we want, that the
powers-that-be, for whatever reason, either dont want us to know
about or refuse to grant credibility to, despite what science is telling
us.
PREFACE
The other important thing to note here is that this information isnt
for everyone. This is high-performance stuff thats intended for the
use of serious people only. Nicotine isnt a magic bullet, so before
you consider taking it for the purposes were talking about, you need
to make sure everything elseyour diet, training, and all the other
supplementation youre doingis dialed in and on point.
Nicotine wont counteract the effects of doing any of these other
things wrong. Its not your diet and training savior. Instead, the idea
is to show you how to enhance the things youre doing rightbut
you need to be doing them right first for any of this to mean anything.
What youre about to read ventures far outside the box with regard
to whats typically recommended for health purposes. Ive written
this report to help you make sense of it all and decide for yourself.
When used under the correct conditions, nicotine can safely accelerate your progress without the side effects common to other fat
burnersbut again, when youre dealing with a substance thats
been stigmatized so viscerally for so long, theres a great deal to
discuss first.
Thats what I want to do with this report. The rest is up to you.
Kiefer
PREFACE
INTRODUCTION
Origin Story
INTRODUCTION
Origin Story
My professional background, aside from my work in physics and
software, involves working extensively with physique competitors
preparing for competition. I realize that many of you arent preparing for competition, but since fat loss and muscle gain mean literally
everything to competitorsafter all, theyve necessarily had to refine
the process to a far greater extent than anyone else in the world
Im using physique, and its methods, to explain how and why nicotine works.
What I found in the physique realm was that virtually all higher-level
competitorspeople who have to get down to insanely low levels of
body fat before getting on stageuse massive amounts of prescription medications like clenbuterol and albuterol, among other powerful fat burners. The less the coach understands about the human
body, the more fat burners they prescribe.
These drugs work essentially the way adrenaline and caffeine do,
by stimulating the sympathetic nervous systemthe flight-or-fight
response coordinatorthrough activation of the beta-adrenergic receptors. When you take these fat burners, youre piling them on top
of a stress load that already exists if youre attempting to lose body
fat with exercise and calorie restriction. This means youre eventually going to reach a point of diminishing returns where theyre no
longer effective.
The world of physique competition is saturated with these medications. Youll have a difficult time finding a conditioning coach for the
stage who doesnt recommend taking a lot of them.
The competitors coming to me didnt want to take these drugs
because they destroy the metabolism and can overtax the adrenal glands, leaving the body devastated after the competition.
Some of my clients experienced this themselves, and all of them
said theyd seen it happen with others in the aftermath of contest
preparation using fat burners. After youve taken them for a while,
you go through a rebound effect where you gain weight and fat,
and theres absolutely nothing you can do about itand its all as a
result of the drugs, which Ill explain as we go along.
INTRODUCTION
10
Although the right diet can get you very close to where you need
to be (unfortunately, most coaches dont use anything remotely
resembling the right diet), you can definitely give yourself an edge
if youre willing to take these prescription medications. After seeing their adverse effects, however, I wanted to give my competitors
a natural edgeand I wanted that edge to be even more effective
than the pharmaceutical one.
What These Drugs Actually Do To You
When prescription fat burners are working properlyIll explain
why they stop doing so, and what happens when they stop, later
onthey increase your metabolism and coax your fat cells to help
release fat into the system. This is especially important because
most, if not all, traditional diets stop this process. The diets that
most competitors use make it almost impossible to mobilize body
fatnote the use of the word mobilize, and not burnso you have
to add the drugs in order to make everything work.
From what Ive seen, the diets of the vast majority of competitors
are so bad that massive amounts of prescription drugs become
necessary to fix the damage these athletes nutritionists and coaches are inflicting on them.
INTRODUCTION
11
INTRODUCTION
12
INTRODUCTION
13
CHAPTER 01
CHAPTER 01
Dont Just Burn Fat. Lose It.
Exercise is supposed to get you lean, right? This is obviously the
common wisdom, because exercising burns more fat than activities
where youre not exercising. What you need to understand, however,
is that everything burns fat. Sitting at your computer all day burns
fat. Driving your car burns fat. Just about every activity you can possibly undertake will burn fat (even if at a very slow rate)1.
Trouble is, burning fat is a completely separate and independent
process from losing body fat, and thats the distinction most people
fail to understand or acknowledge. We know that fatty acids are
coming in, and we know they go into the oxidative pathway to get
burned for energy. Thats how fat is burned.
We know all this, but where does this fat come from? Well, its mostly from your dietand when your diet cant supply enough, it starts
15
to come from liver reserves, if possible. Weve also just learned that
the entire intestinal tract in the human body has specialized cells
that store fat, too2. In other words, youre getting a fat dump from
places that dont necessarily contain the body fat youre trying to
lose.
The solution? When youre trying to go into any kind of available
energy deficit (calorie deficit), or youre dieting down for the competitive stageor you simply want to stimulate fat cells to lose fatyou
have to create the right environment for this to happen.
For example, a very low-fat, high-carb diet for weight loss will actually force fat cells to refuse to release body fat3-5. This type of diet
will make them try very, very hard to hold onto body fat. Exercising
too much has the same effect, especially when were talking about
cardio. The misapplication of cardio actually forces fat cells to not
get rid of body fat6.
What this means is that even though youre burning fat in your muscles, youre not mobilizing your body fat reserves. This is why people who rely on cardio to get rid of body fat fail. Even though theyre
burning a lot of fat, its only the fat theyre eating and the fat stored
in muscle tissue7. Their fat cells arent releasing it to be burned.
CHAPTER 01
16
CHAPTER 01
17
CHAPTER 02
CHAPTER 02
19
CHAPTER 02
20
CHAPTER 02
21
CHAPTER 02
22
CHAPTER 02
23
Far from it, as Ill discuss later on. The purpose of this section is to
explain why chronic smokers are thin, and why they gain so much
weight back when they stop smoking. Smoking is a deadly habit
that devastates countless systems within the human body, and my
recommendation is to stay as far away from cigarettes as humanly
possible.
CHAPTER 02
24
CHAPTER 03
CHAPTER 03
Nicotine and Muscle Growth
Its fat loss properties notwithstanding, what really excited me about
nicotine originally was its potential as a muscle building agent.
Every cell in the human body has a pathway called the target of
rapamycin (TOR). TOR is essentially a regulatory chain for growth.
If its stimulated, your cells will tend to bring in nutrients, theyll grow,
and if theyre in the correct situation, theyll cause proliferation.
This, obviously, is the ideal situation for muscle cells, and its the
reason insulin and glucose help us growbecause theyre direct
stimulators of the TOR pathway. Leucine is also a regulator of the
TOR pathway, which is the reason youll always hear me recommend leucine supplementation with all my programs.
The problem with glucose and leucine, however, is that they can
both cause releases of insulin. This is not an ideal situation when
youre trying to get rid of body fat. In contrast, the amazing thing
26
about nicotine is that its one of the fewif onlynatural, nonnutritive substances that directly stimulates this TOR pathway of
growth27.
This has two advantageous effects. First, if youre trying to get rid of
as much body fat as possible, nicotine is helping to preserve your
muscle tissue. If youre getting a growth signal, your body wont
destroy this tissueor, at the very least, it will attempt to avoid
destroying it. Next, if youre in a hypertrophy phase where youre
trying to add mass, youll be giving a stronger growth signal to your
muscle tissue.
Nicotines Effect on TOR
If you want to increase growth in any cell in your body, you have to
activate the TOR pathway. If its turned off, its very hard for your
body to grow. Rapamycin is an anti-cancer drug that turns off the
TOR pathway, essentially negating any gains you get from resistance training. When this pathway is turned off, you can lift weights
all day, every day, without any benefit to your muscles.
When the TOR pathway shuts off, you cant grow. This is obviously
beneficial for cancer patients, because it means no cells can grow.
Cancer cells are typically highly rampant, and they grow rapidly, but
CHAPTER 03
27
CHAPTER 03
28
CHAPTER 03
29
CHAPTER 03
30
CHAPTER 04
Controversial Aspects
CHAPTER 04
Controversial Aspects
What, exactly, is nicotine?
Nicotine is just a naturally-occurring substance produced by a family
of plants called nightshades. This family includes tomatoes, potatoes, bell peppers, hot peppers, and the tobacco plant42, with which
its most commonly associated. Nicotine is really just a small natural
moleculelike caffeinethat happens to bind to some really cool
stuff in our system. And on its own, nicotine is nowhere near as evil
as youve been led to believe.
We regard nicotine as dangerous because our thinking has been guided, historically, by the effects we believe it has on smokers. What we
dont take into account, however, is that smokers ingest nicotine every
single day in dangerously high levels. For years, a typical smoker will
take in 60-80 mg on a daily basis. That kind of dosage for that length of
time is dangerous, and research has shown this time and time again.
32
CHAPTER 04
33
If youre young and healthy, theres very little risk of nicotine having
any deleterious effects with regard to cancer, but there are some
other negatives. Its been shown to age arterial tissueyour arteries
and veinsbut thats only when taken in very high dosages over a
long period of time.
We see this advanced aging of the circulatory system most frequently in smokers, who often experience a hardening of the arteries49.
The dosages of smokers, however, get up into the 60 mg per day
range on a daily basis, and this can happen for decades50. Again,
as youll see in the protocols section, Im recommending much lower
dosages, because you dont need anything near what smokers
ingest to experience the benefits of nicotine. These lower dosages
serve to attenuate the potential downside.
With smokers, nicotine adds yet another double whammy effect.
Everything else contained in cigarettesall the tar thats entering
your lungs, for examplewill create the cancer, and then with all
the nicotine smokers constantly take in, theyre essentially telling
the cancer to grow faster. This is why lung cancer is usually the first
form to develop in smokers, because the nicotine is having an effect
in the lungs very early and very quicklyinteracting with cancer
cells that are already growing rapidly.
CHAPTER 04
34
CHAPTER 04
35
CHAPTER 04
36
CHAPTER 05
CHAPTER 05
Unique Benefits of Nicotine
Nootropic Effects
The ability to reason correctly and logically is a lost art in todays
world, and nowhere is this more evident than in the fitness, health
and medical industries. Logical thinking and the ability to make reasonable connections across large amounts of information depends
on whats called working memory52.
Both animal and human studies demonstrate that nicotine, through
novel receptors in neuronal tissue, can increase the efficiency of
working memory53-54. Nicotine can impart a clear benefit for test taking and technical tasks like figuring out your taxes or programming a
computer.
Appetite Suppression
The unfortunate downside of most fat burners is a potential increase
38
CHAPTER 05
39
CHAPTER 06
The Protocols
CHAPTER 06
The Protocols
To find the correct dosing necessary for the fat mobilizing and burning effects of nicotine, we first need to investigate nicotine metabolisation and blood concentrations necessary for these benefits. For
this section, Im going to discuss the use of nicotine gum, since
most of the data from human trials looks at peak nicotine levels and
clearance rate using gum. We can therefore make sure our dosing
achieves the blood concentrations needed for results.
Direct research on the increase in energy expenditure via nicotine
shows that a 1 or 2 mg piece significantly increased resting metabolism and demonstrated a dose-dependent response58. In other
words, the greater the dosage of nicotine in the gum, the greater
the effect. This study, unfortunately, didnt measure blood nicotine
levels.
In the above cited works17,19, the profound effects seen on fat mo-
41
bilisation and increased fat oxidations were achieved with intravenous infusion of nicotine until levels reached between 7 and 8 ng/ml
(nanograms per milliliter). This would require a piece of gum containing 4 mg of nicotine59.
So, if we want the maximum benefit of fat burning and fat mobilisation, well need to chew 4 mg pieces of nicotine gum. With this, peak
levels of nicotine will be achieved within 30 minutes of chewing and
maintained for roughly two hours or more59.
Researchers also demonstrated that even modest amounts of caffeine added to the nicotine gum significantly increased energy expenditure58,60. If you plan on taking caffeine to enhance the effects of
nicotine, I highly recommend drinking coffee, as it contains chemicalscholinomimetics61-62that may bind to the same receptors that
give nicotine its unique ability to empty fat cells63.
For most people using my programs, the basic beginner protocol
for nicotine entails taking 4 mg first thing in the morning. I advocate
morning ingestion for two primary reasons. First, as I discussed in
the previous chapter, its a good idea to keep your nicotine ingestion
away from your carbohydrate intake. This is why you want to make
sure its cleared from your system when youre loading up on carbs.
CHAPTER 06
42
Next, nicotine will elevate your body temperature, and its also a
stimulant. Both of these factors can and will affect the quality of
your sleep. So, at least until you figure out how your body reacts to
it, limit your nicotine intake to the first part of the day, so its at least
partially cleared out of your system before you go to sleep.
You should ramp up your dosage if youre not accustomed to nicotine. Start with half of a 2 mg piece for the first week of use and step
up the dosage by half of a 2 mg piece per week until you reach the
desired 4 mg level.
Nicotine For Carb Back-Loading
When youre on a typical Carb Back-Loading regimen, nicotine can
be one of the most powerful weapons in your arsenal. This is especially the case first thing in the morning, when youll either be skipping breakfast or eating pure fat in the form of heavy cream and/or
coconut or MCT oil. As weve discussed, nicotines primary advantage in this case is the mobilisation of body fat. This will trigger more
ketone production, and itll accelerate your body fat loss.
With Carb Back-Loading, I recommend training in the evening as
the best option, followed by training first thing in the morning as the
next best thing if evening workouts arent feasible. Since the ideal
CHAPTER 06
43
time to take nicotine is early in the morning, this is an especially effective protocol for people who train in the early AM hours.
Since nicotine is such an effective supplement for accelerating body
fat mobilisation from your body fat stores, itll ensure that your training does exactly what you want it to do. Again, training is going to
burn fat, but this isnt necessarily the fat thats actually on your body.
Nicotine helps you target body fat loss, making your workouts much
more effective60.
MORNING TRAINING PROTOCOL: 2 mg before training, then 2
mg immediately afterward.
When you train later in the evening, the key to using nicotine effectively is keeping it as far away from your carbohydrate loads as possible. In this case, the protocol remains the same, at least in terms
of restricting your nicotine ingestion to the morning hours.
EVENING TRAINING PROTOCOL: 4 mg upon waking.
For people using the Carb Back-Loading Density Bulking and
Strength Accumulation protocols, there are subtle differences between the way nicotine is used for each.
CHAPTER 06
44
CHAPTER 06
45
CHAPTER 06
46
CHAPTER 06
47
Cycling
Your goals for nicotine usage must necessarily be short-term in nature, as opposed to thinking youll be taking this for the purposes of
lifelong maintenance. Although the research says nicotine use in the
small doses Im recommending here is perfectly safeand highly
effectivefor fairly long periods of time, were still not completely
certain with regard to the absolute long-term safety of these protocols.
The idea, then, is to cycle your nicotine intake on and off. A good
rule of thumb is to try the protocols for four weeks, then take a break
of at least two weeks where youre not using any nicotine at all. This
cycling, as far as research can tell, should mitigate any of nicotines
downsides. When combined with the low doses youll be taking, this
wont have any adverse effects on your health.
CHAPTER 06
48
CHAPTER 07
A
D
E
R
_
[
]
_
D
E
T
C
CHAPTER 08
CHAPTER 08
Frequently Asked Questions
How do I take nicotine?
These protocols have you chewing nicotine gum in 1 mg segments.
Chew the gum for thirty seconds or so, then tuck it in your cheek.
Repeat this process until the nicotine in the gum is depleted.
How will this affect my training? Will I feel any difference?
Theoretically, nicotine should give you slightly more muscular endurance during your heavy training sessions, so you might be able to
squeeze out one more rep in some sets because nicotine adapts
your cells to fat oxidation more readily.
As far as feel is concerned, youll be warmer, youll sweat more,
and youll be slightly more intense because nicotine is a stimulant.
Remember, though, nicotines performance benefits are pretty
57
CHAPTER 08
58
CHAPTER 08
59
long-term data to make definitive statements yet, but what Im trying to do here is give you cutting-edge information to increase your
performance and your fat loss results over the short-term. There are
always risks to being radical.
CHAPTER 08
60
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