ACROMEGALIA

Different causes of acromegaly. In more than 99% of all

cases, a monoclonal pituitary tumor can be demonstrated (classical
acromegaly). The ectopic GHRH syndrome is the second most
common cause of GH hypersecretion. Eutopic GHRH secretion
from hypothalamic lesions cannot be differentiated from classical
acromegaly before operative therapy. The extremely rare ectopic
GH syndrome has been demonstrated unequivocally in only two
cases. SRIF, somatotropic hormone release inhibiting factor.

Features of acromegaly/gigantism in identical twin

Appearance of a patient with florid acromegaly. Cour- f0005

tesy of Professor Stefan S. Fajans.

Increased incisor spacing and prognathism in patient with

acromegaly

Macroglossia (left) and a normal tongue

(right)

Harvey Cushings first acromegaly

patient. A, Some years before presentation and
(B) at admission. (From Jane JA, Laws ER. History of
acromegaly. In: Wass J, ed. Handbook of Acromegaly.
Bristol, UK: BioScientifica; 2001:3-15.)

Tabarcea Eduard
Amza Diana
Studenti an III ,Medicina Dentara ,Universitatea Oradea
Bibliografie
-Endocrinology Encyclopedia ,Luciano Martini
-Endocrinology ,Dr Paul Bolin
-Williams Textbook of Endocrinology 10th edition