QUESTION 1

The mutation, which results in Sickle Cell Disease, is usually in a

specific gene.
a) Which chromosome contains this gene?
b) What polypeptide is coded for by this gene?
a) Sickle cell disease is caused by a mutation in the hemoglobin-Beta
gene. The chromosome that contains this gene is found in
chromosome 11.
b) The cause of sickle-cell disease is a point mutation, meaning the
alteration of a single nucleotide base within the DNA of the gene
coding for the beta-hemoglobin polypeptide.
QUESTION 2
a) What is the specific change in base sequence in the mutant gene?
b) What is the specific change in the amino acid sequence of the
mutant polypeptide?
a)