Documente Academic
Documente Profesional
Documente Cultură
Type 1 Diabetes
By Franny, Shasta, Ethan, and Emily
Type
Diabetes
Our
Problem
Previously
Solutions
Attempted
Current
Limitations
Currently people have tried to add new beta cells to the pancreas by a
donor donating these cells. One of the problems with this is that the
bodys immune system will again attack these new beta cells rendering
them useless within a year. Possible solutions have been to create a
shield around the cells that has holes in it. These holes are small enough
to let blood cells and insulin pass through but not T cells of the immune
system.
Proposed
Solutions
Our proposed solution is to create new beta cells in the patient. Using stem cells
we could grow new beta cells in a lab and transplant them into the patient. The
Beta cells could be placed into the patient's pancreas where there are no more
beta cells. Then to protect the beta cells from the immune system we could
attach a barrier onto the pancreas to protect the cells. This barrier will let insulin
out but will top the immune cells from attacking. Companies are already trying to
create this.
Production
1.
2.
3.
4.
5.
6.
7.
Characterization
Our solution can be mostly recognized as a surgery because it involves (an)
incision(s) where beta cells will be replaced and a semi-permeable membrane
will be added. We can confirm that the new beta cells are real by either
extracting these cells from already existing stem cells from infants or from the
patients (or a donors) bones.
Testing
Since our solution involves surgery, we would have to test on
animals (like mice) and do surgery on them before applying it to
humans. The beta cells need to be injected onto the islet tissue of
the pancreas. In the near future, testing on 3D printed organs or
creating cloned organs to test medicines and surgery on would be
another way to see if our solution would work in the correct way.
Our
Virtual
Mentor
Citations
http://www.joslin.org/
http://www.diabetes.org/diabetes-basics/type-1/?referrer=https://www.google.
com/
http://www.hormone.org/contact-a-health-professional/what-is-anendocrinologist