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5. DRINKTNG.WATER CASE.$TUDY
5,1 Ohjective
The objective of this fictionai case-study is to demonstrate how the principles and road maps
that conrprise the Toolkit can be used by a public health or related professional to evaluate
potential risks of chemical contaminants in drinking-water as a result of emissions from a
discrete or point source. The specific road maps for this scenario are shown in Figures 8-l I
below.
While the aim of the case-study is to demonstrate the thinking behind all stages of human
health risk assessment, including hazard identification, hazard characteization/guidance or
guideline value identification, exposure assessment and risk characterization, the user of the
Toolkit should be aware that measuring substances in drinking-water for which drinkingwater guidelines exist allows a quick and very first assessment of how big a problem there
might be and whether there is a need to pursue this.
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Guidance or
Reference URL
(2010a)
http://apps.who. inVipsc/database/evaluation
s/chemical.aspx?cheml D= 1 376
WHO
(2008a)
guideline value
Food
guidance
varue
guideline value
FAOIIIVHO
for
in that
section, the guideline value is based on a d.efault ivater
consumption rate of j lires per day, a
body.weight of 60 kg and an allocation to water of 10%o of
the pTWl. It is recognizedthat
population average water consumption rates can vary
significantly, perhaps by a factor of 24, in different parts of the world, particularly where lonJurr"r,
#'"ogaged in manual labour
in hot climates. Similarly, typical bocly weights can also vary
among countries or regions,
with the much larger range in toxicological uncertainty that exists for the vast majority of
chemicals. Consequently, the default assumptions for those parameters are likely to be
adequate in nearlv all situations.
ln order to account for the variations in exposure from different sources in different parts of
the world, a cefiain proportion of the ADI, TDI, PTW[, etc., generally between 1o/o and 80o/o,
is allocated to drinking-water in setting drinking-water guideline values for rnany chemicals.
Where relevant exposure data are available, authorities arc encouraged to develop contextspecific guideline values that are tailored to local circumstances and conditions. For example,
in areas where the intake of a padicular contaminant in drinking-r.vater is known to be much
greater than that from other sources (e.g. food and air), it may be appropriate to allocate a
greater proportion of the ADI, TDl, PTWI, etc., to drinking-water to derive a guideline value
more suited to the locai conclitions.
Output: The WHO drinking-'vvater guideline vahre.for cadmiwn is based on a
default water consumption rate of 2 litres per day, a body weight of 60 kg and
an allocation to water of'10% oJ'the PTILL.
Do those assumptions reflect conditions speci/ic to the local situation?
In the case of Riveftown, the RDEH would require detailed information on lbod consumption
patterns, cadmium levels in specific foods and ievels of cadmium in air and soil to consider
deriving a context-specific drinking-water guideline value for cadmium The water is not used
for inigation of crops, so, in the absence of information on contact rates, body weight,
absorption fiaction and total exposure to cadrnium from the general diet specific to local
conditions, the RDEH elects to rely upon the WHO drinking-water guideline value for
cadmium of 0.003 mg/l in the risk assessment. This is an appropriate decision, as the WHO
drinking-water guideline values account for ingestion through food and are considered, in
most cases, sufficient to account for intake of contaminants through inhalation and dermal
absorption.
OutpLtt: The WHO drinking-water guideline vahte.for cadmitun oJ 0.003 mg/l
is appropriate to be used uncler the given local conclitions.
A road map for the hazard characterization step of the drinking-water case-study is shown in
liigure 9.
In what ways could people corne into contact with the chemical?
The river forms the basis of the water supply to the town, so exposure through drinking-water
is likely. Water is also used for cooking and bathing. It is important to consider whether
drinking-water consumption is likely to be significantly greater than the 2 litres a day for
50
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aduits used by WHO to derive the drinking-water guideline. The water is not used for
irrigation, and therefore it is unlikely that food crops are contaminated.
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Output: People come inlo contact v,ith the chemicul tlrottgh water. lngestion
of drinking-w'ater and water used Jbr cooking and dermal absorption through
bathing are the most relevant routes ofexposure.
It is important to obtain further information on the concentration of cadmium (and any other
identified contaminants of concern) in order to more accurately assess exposure. Where there
is water treatment, it rvould be appropriate to measure the concentration in water at the water
treatment plant after heatment. I{orvever, cadmium can also leach from galvanized water
supply pipes (usually in buildings), so if such pipes are in use, a sample at atap in a building
using such pipes would be important in judging overall exposure from drinking-water. Crops
have not been irrigated, and therefore crop sanples are not needed to judge the total exposure
to cadmium.
Measurements require that the assessor has access to appropriate protocols and supplies for
sampiing, storage, transport and analysis of water samples obtained from the river and
drinking-water. This also means that there must be access to suitable analytical facilities with
an adequate level of expertise and qualiff assurance, as incorrect analytical data are highly
misleading and have led to inappropriate ciecisions in a number of circumstances. ln some
cases, it may be appropriate to use models to determine how much of a contaniinant will
reach a point downstream from a discharge. Modeis require information on the discharge rate
of cadmium through the effluent pipe that extends from the facility to the river.
Unable to obtain information needed to model the concentration of cadmium in water drawn
from the river, the RDEH makes the decision to estimate long-term average exposure
concentrations from direct measurernents. Infonnation on sampling and analysis methods is
available in EHCs and CICADs prepared for specific chemicals. EHC 134 on cadmium
([PCS, 1992) contains introductory information on analytical methods for cadmium,
including collection and preparation of samples, separation and concentration, methods for
quantitative determination and quality control. Specific methods for sampling water and
analysis of cadmium and other metals are available from country resources, such as the
USEPA's Method 1669: Sampling ambient water for trace ntetals at EPA water qualityn
52
Table
21 :
loo/,rl
Location
<LOD
<LOD-0.2
0.4
0.1-1.0
0.3
0.2-0.8
Upstream of facility
Downstream of facility
The results of the water sampling indicate that concentrations of caclmium downstream of the
metal finishing facility are greater than concentrations upstream of the facility. The results
also indicate that cadmium concentratiorrs in potable water received from the Flowing River
are approximately equal to th.e levels in the river downstrearn of the facility.
1s
occur?
The assessor has knowledge that the facility routinely operates 24 hper day, 7 days per week.
Therefore, long-term average conditions and long-term exposure are of primary interest. The
assessor should also consider variation in operations of the facility or flow of the river that
could result in transient increases in exnosure concentrations.
oJ' the
Jhcility.
Having selected the euvironmental medium (water), exposure route (mainly irrgestion) and
exposure duration (long-term) of interest, the next step is to determine if an international
guidance or guideline value exists that corresponds to those cdteria. In this case, data
gathering conducted in supporl of the hazard characterization step revealed that WHO has
established a guideline value of 0.003 mg/l for long-term ayffage concentrations of cadmium
in drinking-water. The fcrrrr of the guideline value dictates the form of the exposure estimate
reqnired for the risk characterization step. Thus, the risk assessor in this case-study requires
an estimate of long-term averege concentrations of cadmium in water drawn from the
Flowing River in order to proceed to the risk chatacterization step.
i's
road map for the exposure assessment step of the drinking-water case-study is shown in
Figure
10.
)J
E4:asrtre tlrte ct
drinking-water case'study'
Figure 10: case-specific road map for exposure assessment:
described in the text'
analysis
and
gathering
information
of
Bold lines indicate the flow
""porr',r.'*ould
If
the concentration in the river was below but close to the guideline
value, it would still be
appropriate to determine whether there was potential
from the phimbing
""porur:"
system.
In
terms
of actions,
vent
conditions change.
A road map for the risk characterization step of the clrinking-water case-study is
shown in
Fisure 1 l.
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Figure 11: Case-specific road map for risk characterization: drinking-water case-study.
Bold lines indicate the flow of information gathering and analysis described in the text.
Wssessrnentfoolkit
5,7 Summary
An
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