SIRIPHATTARAWONG 1

Julamanee Pim Siriphattarawong

Mr. Abel Cadias
English 10 / 1005
June 26, 2016
The Negative Effects of Taking in Numerous Paracetamol
Taking in too much paracetamol causes people to become addicted, liver
damage and rebound headaches. The purpose of this research report was to identify
the effects of paracetamol. The importance of this research report is to provided
awareness on the negative effect of taking paracetamol. The pieces of the information
found in this researched report were based on eight references. First, according to
Carole Pelland, the writer of the website tried to give the information to the people
who overuse the paracetamol. Second, Michelle Roberts articles showed the result
about how paracetamol is dangerous to human. This article also provided paracetamol
warning by explaining the different type of symptoms from the university research.
Third, the article from Multum Information Services gave the example of the diseases
and rare symptom that causes from paracetamol. Next, the article from Graham
scholarly article or American Journal of Therapeutics compared paracetamol with
other of medicine and how it affect to the body system. Fifth, the article was about
Robin Dodd. She gave examples of the case study that died from paracetamol drugs.
Sixth, the article from Mahidol University was mainly identify about the advantages
and disadvantages of the medicine. Seventh, the article from medicine website was
telling how rebound headaches happen and what cause rebound headaches to happen.
Finally, the article from Tepper shown how to treat the rebound headache.

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Addiction to Paracetamol

According to the evidence, many people use overdose of paracetamol and

become addicted to it. This means that the paracetamol have advantages and
disadvantages to the users from using in more than five days. The advantage of
paracetamol is that it can decrease the pain of the patients. The disadvantage of
paracetamol is that it contain the high amount of toxic that can kill the users from
overdose. To avoid themselves from overdose of paracetamol the patients take in
paracetamol by following the doctor prescription. Paracetamol can makes the users
become addicted from using every days, weeks and months. The effect that cause
after taking overdose are the feeling that you get angry easily, feel worry, painful
symptoms, vomiting and die from pain after use for a long period of times (Pelland,
2011). After the experiment, the researchers told the British Journal of Clinical
Pharmacology that doctors may not know how much paracetamol that the users take
in from the blood test until the damage builds up and show the symptoms (Roberts,
2011).

Liver Damage from Paracetamol

Paracetamol is a type of medicine that the users can buy it at the drugstores.
Even though, the paracetamol are safe medicine to use when your body feel hurt, or
pain. The doctors still not allow the user to take in more than four grams of the
paracetamol per day because it will increase the amount of toxic in the liver call
hepatotoxicity Effect of the paracetamol are acute liver failure. Acute liver failure

SIRIPHATTARAWONG 3

happen with the people that are addicted to the alcohol, liver disease because the
amount of toxic metabolite in their stomach are produced differently from other
people. Which are more dangerous to take in four grams of paracetamol per day. So,
they are not allowed to use the paracetamol. Normal people that dont have a problem
with their liver will produce the toxic metabolic normally to metabolism the food or
any chemical that you take in but it can still cause the acute liver after use the
paracetamol for a long period of time or overdose. To prevent this from happen,
person must read the medicine labels, and not use it more than five days.
The person also not use other type of medicine that also contain the high amount of
toxic like paracetamol for long period of times. As well as see the doctor if you dont
get well, know the exact effect and cause of the medicine before you take in and ask
the doctor for the prescription (Sukka, 2010).

Rebound Headaches

Rebound headaches is a symptom that makes the people feel headache again
and again from the medicine that contains caffeine. Some people that can be affected
by the rebound headaches such as the people that have brain surgery, migraines, etc.
The rebound headaches wont happen to the people who never have headache
disorder. This type of symptoms is one of the most dangerous because the amount of
toxic inside of the medicine can combine with the amount of caffeine. Which can
make people gets shock, cant breath and suddenly die. The ways to treat the rebound
headache such as follow the medicine instructions or the order from the doctor. Even
if, you are headache or painful use the medicine in the correct amount to cure your

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pain and not use medicine too often except the doctor orders you to. At least, dont
mix paracetamol with any kind of drink that contain caffeine (Tepper, 2010).

Conclusion
The purpose of this research report was to identify the negative effects of
paracetamol. In conclusion, paracetamol have lots of negative effects to the user that
overuse it in the long period of time. Some people that overuse the paracetamol will
become addicted. It also causes liver damage and rebound headaches after use for a
long period of time. This medicine will directly happen with the people that addicted
to drug, have toxic metabolites, brain surgery and migraines. This research report
recommends further study on how to decrease pain with another type of medicines
that contain less negative effects to the human body.

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References
Paracetamol Side Effects. Retrieved (May 24, 2016) from
http://www.drugs.com/sfx/paracetamol-side-effects.html
Graham, Garry & Scott, Kieran. (January, 2005). Mechanism of Action of
Paracetamol. Retrieved (May 23, 2016) from http://journals.lww.com/
americantherapeutics/Abstract/2005/01000/
Pelland Carole . (April 7, 2011). Addiction to Paracetamol Drug Addict Help.
Retrieved (May 21, 2016) from
http://addicthelp.org/addiction-to-paracetamol-drug-addict-help/
Roberts Michelle. (November 23, 2011). Paracetamol warning: 'Slightly too much can
cause overdose'. Retrieved (May 21, 2016) from http://www.bbc.com/news/
health-15837468
Sukka, Sakuyamon PhD. (June 1, 2010). Drug Safety and Risk Management Advisory
Committee. Acetaminophen Overdose and Liver Injury Background and
Options for
Reducing Injury. Retrieved (May 23, 2016) from http://www.pharmacy.mahidol.ac.th/
th/knowledge/article/19/--paracetamol-
/
Sydney Morning Herald. (May 3, 2015). Paracetamol poisoning: how addiction to
over-the-counter medication took Imogen Cunningham's life. Retrieved (May
21, 2016) from http://www.smh.com.au/nsw/paracetamol-poisoning-howaddiction-to-overthecounter-medication-took-imogen-cunninghamslife-20150502-1mye1g.html
Tepper SJ. (2010). Rebound Headaches. Retrieved (May 24, 2016) from
hic_Overview_of_Headaches_in_Adults/hic_Rebound_Headaches
WebMD, LLC. (2005-2006). Migraines & Headaches Health Center. Retrieved (May
23, 2016) from http://www.webmd.com/migraines-headaches/guide/reboundheadaches