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• Block dopamine receptors in the brain; also alter dopamine release and turnover.
• Prevention of seizures
INDICATIONS:
Chlorpromazine is used virtually in all types of psychoses. It can be combined with other
anti-psychotics. Chlorpromazine is also used to control anxiety or agitation in certain
patients,to relieve a wide range of drug or disease induced vomiting, and in severe
hiccups. Chlorpromazine is also used in the treatment of tetanus in combination with
other drugs.
• Hypersensitivity.
• Cross-sensitivity may exist among phenothiazines. Should not be used in narrow-
angle glaucoma.
• Should not be used in patients who have CNS depression.
• Coma
• bone-marrow suppression
• phaeochromocytoma
• lactation.
DRUG INTERACTIONS:
Potentiation of anticholinergic effects of antiparkinson agents and TCAs may lead to an
anticholinergic crisis. Additive orthostatic hypotensive effect in combination with
MAOIs. Reverses antihypertensive effect of guanethidine, methyldopa and clonidine.
Potentially Fatal: Additive depressant effect with sedatives, hypnotics, antihistamines,
general anaesthetics, opiates and alcohol.
Chorpromazine has additive depressant effect with sedatives, hypnotics, antihistamines,
opiates and with alcohol. It potentiates the anti-cholinergic effects of antiparkinson agents
and tricyclic-antidepressants, which may lead to a anti-cholinergic crisis. It has additive
orthostatic hypotensive effect in combination with MAO inhibitors.
SIDE EFFECTS:
Blurred vision; constipation; dizziness; drowsiness; dry mouth; light sensitivity; nasal
congestion.Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in
the chest or throat; swelling of the mouth, face, lips, or tongue); changes in breasts;
changes in menstrual period; changes in vision; chest pain; chills; confusion; difficulty
swallowing; difficulty urinating; drooling; extreme tiredness; fever; inability to move
eyes; involuntary movements of the face, mouth, tongue, or jaw; jitteriness; lip smacking
or puckering; mask-like face; muscle spasms of the face, neck, or back; prolonged or
painful erection; puffing of cheeks; rigid muscles; seizures; shuffling walk; skin
discoloration; sleeplessness; sore throat; stiff arms or legs; tremors of hands; twitching or
twisting movements; weakness of arms or legs; yellowing of the skin or eyes.
ADVERSE EFFECTS:
NURSING RESPONSIBILITIES:
BIBLIOGRAPHY:
http://www.webhealthcentre.com/drugix/Chlorpromazine_DI0035.aspx
http://www.mims.com/Page.aspx?
menuid=mng&name=chlorpromazine&brief=false#Storage
http://www.drugs.com/sfx/chlorpromazine-side-effects.html
http://www.nursing-nurse.com/drug-study-chlorpromazine-2-162/
Criteria:
Promptness- 5
Format- 5
Drawing- 10
Content- 45
Nursing Responsibility- 35
DRUG STUDY
Submitted to:
Zenaida Lagrosa, RN
Clinical Instructor
Submitted by:
Jenna Christy C. Matalam
On
January 28, 2010