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B. Causative Agent
Bordetella pertussis
C. Incubation Period
D. Mode of Transmission
E. Portal of Entry
Respiratory Tract
F. Host
Humans
G. Vector
H. Portal of exit
Respiratory tract (either through nose when sneezing or through mouth when
coughing)
Pathophysiology of Pertussis
Predisposing factors
®Young age
®Crowding
Precipitating factors
®Infants who are not yet
fully immunized
Bordetella pertussis
It multiplies
attaches on the
to respiratory
respiratory epithelium,
epithelium.
OncestartingA in thethe
anchored,
mucopurulosanguineou
bacterium
nasopharynx produces
and
s exudate
ending
tracheal forms
primarily in
in the
cytotoxin,the
respiratory
which bronchi tract
stops and
the cilia
from
bronchioles.
beating.
This exudate
compromises the small
airways (especially
those of infants) and
predisposes the
affected individual to
atelectasis, cough,
cyanosis, and
pneumonia.