I

Intoxl'catl.; :sta~ea IPatologlcl 1'I1".",lbill AU illl¥ll'Iii,bfll plI'odusi die una sau ma.i multe ~anobioti:ce d'up. pltrunderea lor tlntr-un arganiism, ·viu ..

'Toxlc"tea: Ipropn'etltli relltiivl I lub.tln'.~lor'ii ce :$8 caracterizeazl prinl Clpaaftltll lor de • proGuCi' un ~I.pun. biollogi.c (efeet,) dup. pl.trundere tn org'.n,.mull viu. II ell.inG'I, de mUll'

facton.; .

'CI_ItI,caNi Imo •• 'IIor:

A. d"pf' ,clltwlul' ,eI/lila.:

1. linto,Jti:QI',li lcut.:

., ,Hlminiltr ... I. 0 aOlllmlr I

.. 1:p8'ri1i1 rlpid. I limptoametor Ontoxica.~i aupnlacute, subacute:)

.2. into>dca,I' crQn'~: .<. ". '.' la termsn scurt (3-6 JunO

lis t.:f'mefl l'Yn.; (,ani),

4' Idmini.~~t_ ,dO,a.lor miicij I rapetMe tJlmllP flnCl.lungl.t .~ C1J.Im'u'.te,

lB.. dupi c""",,' JuridIc::

Claslflca, ... ubetllnt-'Iar'toxl_::

11. ,dup. n:a,tura lor. '~ d.ln.tu~l: ~eg:l,t.~~ 1(II~lO:iZil glicoziide), "d~1 na~url ml,~er-alll.{m~I:'), ~

de, :naturi 8,nlmall (venlne,1 to,Xine)

- toxtei .i;.~'mlticl {cu efect gltnetal., pGtUeiOfbt.iv)

- -

------ \

to,xb:n ai sistemului nervos, central

toldci h.epatici

toxici hematiCi;

- -- - -

3~ d~p. em.,n, fiiico chimic-e:

to~lci gU,Ofi. w1xioi metalici, toxici vo~atni f

.'

imuno

radio TOxicologi~ 1-'1

9'enerall--"'" descllpllvl ,...... : I

analiticl .""

.. t:)

BiOIOQie,

I Oln.tiel

[ Ecologi,e]

. ,.. lo,~icologii., m ~ diLdui (Environmental To,xicoloQY): 8011:111 SCP' in mediu

> Ecotolelcologi:1 (~,totoxiGOlogy'):: efect. aSiulpt,a ,eool,itt.mllor, r.tatn om~m,edlu

)- T:oxi,cologlia d'eclzfo,na,11 (To~Xlcolagy R.gul1atar,;): 'form u,1 a rea, . decizUlor" recomandA,rilor, o',p:,inUior pl1vin.d prevederellmi'Cfolrarea, efectelor polu~rii

,S c.'p : ¢tLb~t.a.·n..~~ eh;"MiC€- pok,(~lJnte..

TruhsutJ, 'f gS9: Intftj,fJ:uc"r8'. ,fe,tmiIJo/O(Jie,; nseQ,toxlcolegie"

.. daune asupra ~sinw __ -Q4,At""ltru'·"·~ . bo 'U- _I • :'~";I!i.' •

- ,I we'CIV~le:l

efecte tardive (mutagen, teratogen)' .

dezecbilibmin elemen .. '

tel,. mC!diuIui (CO'.H 01" '°3, NOJI

diun. tgo]O,IiG8 (p«turbar-el ecosistemului) .~ __ 'dl:ftitta'_~ ~iI' -ca I'Ilkiurilor, extiftdcrea ,de·.III!~'U';10[,

... dame asupm, 'mediului .... \: .,_ It' ""AIl ...... "

/. ..' , '''.. '., . cutrofWdea apGlor Idisl'ari,til uno" specii de

... ,.: ..... , .... 1,"" etc, ~ ... ,

pcrtutbat_ ~hiHbf;elot ~i ciclurilor biologiee

... daUlle uupra bYfiutUot mat~hale

biotic

I.Poluare naturall: mociificarea reverslbill a componentelor nOmlale al:e mediului (C02, CO; HiS", NOJ(J 802, 031 linunda1ii. erup1iii wlcaniC81 efeau'l de se,ri" plai aci:d'e" inverse termiice, etc.

II.Po'lu.,. .~ .... : Iptlrni1i lunOr ,component. Itr.in. 011 urmare a activitl~i, om'UlIUi UIOh.,lr6 ,esA nltufllllntro:r:JiCl, ijlmln mid.").

r·_·-"-·'·

I ,....._.~ I

. - I I 111M I I .0 ..

• '!II! .:lit.?+- ~ J

Av,arii ehiml~ eftcteacute ,.Ie: polyl,rii:

:)0' rispindiire de bioxiG de lut£: McuJC (U]36~" Donara,"PRI}'lvania, Londra

(19'52),;

)0, gaze de ~apament (Ncw .. Y:orkJ Ohi,c, Piasburg .• ""G); ,. :rlspin,djre de hidrosen sldturat: ,Poza Rica" Me:xic;

)0, gaze de q,apament

>'pI01 ,lcide (m,andIJ O~rmGia '80, Mhena, ,;ttjunS,biul negru");

• Se\'eso (I~ali3, 197'6) = talastto~ CU dioxli:illJ~

• Miss.is~aga I(Crumda, 1'978) - e'xp~o6 a unui Uien ell elor;

• ,Pakis,tan -liiecident cu izo:malatiQII (20000 de miI'iIorp);,

• BhopaJ (bdia, 1984) -accideliilt CU mel.ilizociu3t (2.000 de motl,i);, , Yush6 (1aponia)-,aocidefi't cu bifenU dorum~ (PCB);

)-!Moguifilto rehi,lni.e ox:ida,tiv €CH.t .... C(;b;, NOx' 03) -la Los Ang,el".s, MeX,IC:O.t:lty, Tokm (1980-2000). ne~Jmg

)- miqora:rea stratufilolt de ozon;

Ava~ii ,ebilDice" ,efeete 8ltUte: aI,e poluirii (CltRtiDuare):

)0, p'o~S~a~a apelor ,eu, ~i~uri ,(iotE'7 anii 1990~2000 - RusilJ AmerIca, oe. ud, f_nsulele .Fdlpme, Sparua, Romarua);

)0 lh~o~-ie:alii de mui cu al.iment:e co'ntami:Qale (vin bo'ill. de ardei

filna'j ulud!:lemn). !.

D,o'li ,croni,(,c, e,ptdendi

>·~a~a~~\~~aY .. hay (Japon:ia. '60) - into)lica~ia ctonica in masa, CU ). Do'ata Mlllamata (laponil~ 11:8C);

,,. NCUlfop:atia epidemi,c1 CII1 med.:ltHetcut ([tak, Pakistan) . . Efette te'rato,ge,ftlt

>2.4. S T '(ierbiciClj SLl\lm.n~ de ,~upti), - Viitnam ("6:0) )P Talidomida ("60)

Catastllofe nUlclea,re

> Experi,eoJct Cemobll.

\

c

L

'BAZA DED~TE

t:

'I!s •

' ..

....

OBIECTIVELE EV ,- I DARn lUSCtJLM (ENVlRONMBMTAL RISK .ASSBSSMENT, ERA)

II. EVM.DAlIBA.RISCOLm:

(IllSV' .""DaDCI~, I .. AaQ~~"II.,.1

• ff""X'"'

IlL ,eAlAcrERI. .. , IV .. MANAG~

ZAIt£A IUSCULlJI 'MENTtJL 'RlSaILlll (lUSt( 'CHAJlACJ'E. (RISlt MANAGEMD11

HIlA 110M) ",' ,OONTIOL

Care eB 8Mt1ft1. .. INFORMARE

~ incideilsa· CO.lKlJNlCARE, ,.te'lol,advers·

m popu1afie?

fOLITICA DECIZIONALA Acrmm

Rise ima"ptabU ----~--~~~~--~~--~~ij!~3)J

1

~ Rise tolerabil

". I

1'902-,1960 Convupi ¥izJ.Dd oc:mtiral DIDIii, (0013., mum. :apdclI atmosfera:)

1.960 Convm~ Clublluil de La Roma (~ alcntia UIlI,m., plluIrU glcbalt)

1."2" Staddlol'm Conkria~ med.iulul

» UNEP: PRmul Propam lntanIPonaJl :priviad PmtCClia Mld:iuhd ). INfOtE___RRA: Sistem [nlemaponal dc:Jnfol"ll\3iIe

1912.P,'aris InrWl~ UNESOO

1'91.5, HelsInki f;rogmN, 1n vcd,era «liderU, cmSsiel, de suIf' (ell 30%)

1.'985. Vi,eoa, f'rorcJarta, sCtatull!li d,e (IZOfi

1988. Sofia Regte:lhl!fibf,e3 'e,mis,iJi~or de; o:dti de azot $i a f1 UOforiafbonii,QIl'

1919'.Prald'1urt C!lwta "Sltl~tate public! - Mediu"

~ 9 91" G,ene'!!a ~ 9911 ,Esp.o6

RelleliletltNeal emlstilCli{ de subst, 'Ol"gaM'ce voiaille (VOC) Protooolul de EaE~poo, privrnd UJ.l!-Iwea b'ansfronlru,iefi a cf~telot poluarii

~ -_ .. _ =._-

1992" New~:York 1992. Koppenhall

,Confetinla, desp,re ,Cimii P~blema de.$emilor periculoase

J',P2. Rlp IdCtJ,anctm OonferinJa pentIu mediu ~. Silliitai,e

AZeD,da 11: :Progtam Intemali!ol'l3!l pentru Protectla MediulUi ~i S~prMi1a Cl_ci (futemauoMJI Programme ior Chemical Safety. !!peS)

A II-a, Confe,riIl'la, pentrn Mediu $:i s,AnaUle (Environment and Mealill Action PLan fOE"EUIl'iQpe, SHAPE) (P.l)ogpunw de M~dj,u $i SWtate al N<I~tmilor Urute, prin care 5,.81 [,ecomandllt l~turo,[' tarilor din re,giunea europeani\ OMS elaberarea PlaiUJItilot Na1IIRlh! PChW MQtllb., ~i. ,SiDllite)

Panul European de acu:UiIle penmu m~u §i.. sII:Iltate

.1994" Helsinki

1995.0MS

1997.lGoto

2:Q.GtJqblpgpbUIfII. Rela~ta ,dinfR mediu $i. dozvolfaR..1 eco,oomici.

, .. NAY',.i !_rJ;".'

ORGANlSMt $,1 ctlr-iVE~'Tn lNl'E~ATIONALI ctr IMF'LIC'A m MAJOlU: iN IJEZVOLTAltEA rorrnca IlE 'PBO'tI,tTlt A MEotot,Ul $1 SA~A..'f :\:111

WHO - WOil'~4 Helibh Organization (Organiza\ia Mond:ia~§. a, Sbltlpi,

, ,OMS) $l h~.stituli,ime acestela, ! 919" G.sH4va

OHCD - Or:pmzad,cm, {of EcO,n.omi,c Coope.~lIitiofl,and t.'Ievc~opmefiil D'CS - lntergoW'mfi1ellllal Forum Cbemicals Safety (19'94)

IPCS - lntematl:oMl Pro,~e Of cbe:oocaj Saf'e~y

EPA. - El\viroM\enta,~ Jiroleetio:n Ascncy (A,aen\la, de 'PIGI!C\ie a

MediuM) -a. !~Ibo,ra.l. .. Gbid:ul pentm ~c·tcrizarea riselJui," (1995) FDA. - FOOdan:d Dmg: Ad:m:WstmUon (Admirumatia atimenta;:iei :ii a.

medicameotelOr)

J:AO - Food! and ,A,grieutWe: Or,garusation F'DCA - Food. and Dru,g Cosmetics AdminlsntiG.n GRAS-Uste- Genemu:y'Rec~gniudI tv., SMe

O.D ~ Office ofB.nrirQ~ent:al Poli~

i

\

,

'" ,

l5lOl-1J6O lMO

~_- ,ftdad • ..x.-_ c.. .. __ ~ ---,.:'Ia

1m .... 'n' ......... ..... "-

• _.1oaI

td'.-UNIICO

......II, ........... "IUII(.,.)I

.....lUItUIuldiluea

~ CdliSillOI'MlxLU M,1IDt ,l, •

ttuO~dor "

C1wta .. SIAI1atC pub1icl,~MaUif

.......,. OlII1iLar'ldlllibIt. ,or..- volUll ,(VOQ Prot_11il dIt la-lIoi, pfiwwt ~ trIdIiN .... ,

.... 01 polulllii I

"~

II

1\

~m'*-YOlk 11ft,'~".""

" •. ",18*1 •• ~"":"ill""

A .... \.:lI::"..~,PIIIfh ..... , Mlliallli til Sitwtn\& CbimieI OfttMl"lMMlIIIl . , ~f1O~ for CheQQIJI SafelY. lPCS)

,tN, HIItlIldI A U .. Cot.Mftili, pen'b'u Metliu ~ SltIItMe

. (latllHmlnt ill JiMlIbMUQA :'WIi tor l"iII" '1iU!PE) (PIIOJl'IiIJWIIdc MedIu ,i SlalWcIIZ X...,

Unite, priIIi CIIIlI' H recolDlJlda IUiUNr tIIIar- .. NaIm*' .... ,OWS dIbOIINI ,....uo,.

........ ,._MIIIII I)

....... _'.' ,..1 " ... 16"

1""1",',_.E~ _ "".(.'1 .,.': I.~

"-S77e-1 : ... _ .....

\ 1'" ~l..t! I ~, " ..', 1

&.- ......

,OIlGAMlMI,I,COi'VINTD 1nI.I~Tla"A"Z CV JMKIC&1U MAIO. IN' DuvOLt. ' It. 'Ol.mc:1I DE

. :PIOTIC11I A MlDitlLtn ,IIAN1TA1'D .

waG- WIlY KII1~orllA".,(CH"" M-d"jl'l, Slaititti.

.' ,OMIJ , WtltilCWt E9t,9" 0iaM

OKCD -err."• f6r IkIoa4mlc CoclpIIIUoA - DM1optUm, IJCS - ~,'CUI&D 0hIm1Ml11IIIcr (1"4) ,IPCI- ~""".otebl"''' .

.. A- ~"""D"',~&JI.~ •.

Mldlall'" • .:oil ... .,_. #lll.i .... 1 . - _ ....... _- .c-.t' ...... (1-5)

_1M,. _ '."","YIIiI8UI,.au~"""IiWII,"""'UI " .1':;';,'

:I'DA- rGOCt_,_ "".'0' ..... -(MmIIO' ..... aI:IIIea ... II.

"''''UIIIor)

P&\O' ~ 'Food. U4 Af;IIautIlUl OtplIl.1ioa

DCA - Food.ait DNa Caaned'(lI AdmfDiIIntioIl O ....... -GeDcaUy llecopbed. N lite

0 .. - OIIDi;Of~PoUCV '. ,-- ,a.

~

. " ,

I

I

I

AndI ... '_" .. lIt,ioWd:

.' ~Mi~" biald,. 1IIt: (1114), Daa_"lIIIJIwrd, l.cIa6a

(, •. '2)i .

,. ..... __ tWlW~.,trk. GkiI~"krIINrJ. ·"O~);

',_ _....-.. .• '*-i '_"1~

,. ......... ftl

.,. piat. uidl (0 .. CIIrmUII. '10, A tt~l .. Piul. MIlk';,

• ... (\ItAlil,l"6l "" .. tIOIlU _

• MUIlII'Ii' (tMIiM, .1MB) - .tiiI,.\Ii np fii tior;

• .......... iNiIUi liM iIitft.tMiili gooO .: molP)~ .

I •• , ~ 1'9,M)·~MkI6N Gil ~iMIi. (1060 .. lIIi11)i

• YuIM (' .... )~_ ... IIl.wMIiMW $~ {tCl:};

" _~.IisM()*Oal ... ilLiiAlpIll,

\

.A"arU ,ui.l-. ~.h . ,,,,-. .. ..... i.. - .. I iii-

, - _,_ - n. ''''-un)::

"I:~::' "I'~8~~'!=iOM ~ l",,,, AmIlIa

)I ~ 4u 'limihte c66tilmiMt8 ('Iii) bQit .. ,lfdIlt

Boll ~ro.lee. .pWellY .

"~~v~"Y (lipoDia. '60) - iDtoxicaJii ctoftla 11 muI, ,lUI '_'IoIIi,.M1iMwa (I~ ~80);,

"N.~'" MWtmlIl CUi _-=II .... __ ~ ... It_I.. llDoh... IJ..'

.' -r HIIiI!M.MllCAiiUI" ,\,.u~ "-: 1111

&,... ....

"a, 4., 5 T ,(Wdld. ....... Japtl) _ ...... , (110) "'T~(·.)

Catul:N ..

,. Ic.n.w.

"

[ POLUARE:]

modificarea eompo.. '·6 -.. -..:I. ,-. 1- -" ~-.. .. n· .. ".x.""r- ~ nentelof nonmle. unpun1carea, m~lU w wCO UWIIW "". .

cu ICOnsecinte neptivet toxiceprin:' " prezenta unOI

- 'bo:li ,ICU1e: IC.dlfICU) componente strtin.e

bob Cfoniec .

.. , daune uupra slDltltii~ ........ _ boli ale eivilizatiei efecte tardive (mulai,eft,totltogen)

dezechUibru bl etemefi"" telemediului (C02" 02' ,°3; NOJ

danae eeologice (perwrbarea eeosi,stemului) (defrisarea pldunlor, extirnderea d1lerturilor,

.. dauD,e: uupra m.4iului ~~- eutro ofizarea aNi,,~"'l()r •. 4ispari,ia unOI sf'iIi-"U de

/ ~ animale,~. r-· > ,.....

perturbarea echilibrelor

§i cielurilor blolegice

.. dame lSupta bunurilor materiale

biotic

abiotic

I.IPoluale natura": Im,oGlfi:carea revel'lib:ill, a componentelo:r niormal'e ;ale mediului (COa, CO, H~, NOx)) S021 03!1 inundatiill erup"i vlu'l,canice, ,efectul de, sera~ ploi ,aci,de', iinverse termice, etc.

II.P'olu.r. IrdfiCitll: ap'sriti'Q unor component. attAin., 101, lurmare a actlvitl~i\ omului (po~luare' de naturi EI.ntropi'CI, IImln mld .• ''),.

rL-'~I-_IIjII_-

I ~,,,,, :

I ·DIUIrd I

·'_'-'--.-iiiiiiII

"-'~.I- ••• '

~... I

I nr- II

I ,,... I

.."

.--_ .... J

1--" -.

IIDErmFI.CAREA PIERICOLUL!UI (HAZARD IDENTIFI,CAnON) (ASSEIIING TiOXl,CITY OF CHIMI~LS)

' .... rd. PlrlCGI: _

,.. :8ursA :I8U acUvltate CU polen,all periculO, (a. Iccidentare, lea"., lboall, m.osde) Tn ,anum it. cillcllJma1jnte Iptdfiol;

')0 ,capaclatee linerentl a unei Subltlurlte, dihl1iCl~ i),iDlog.iC8, .,·ant ftzic

,de a p,roduce _feet. dlulnl'Oare (OMS); -

~ efad poten,.'l notiv.

Scopul: dacilUDltlnta cauzead efettfl a~verse'

-'- -

OllleTIVal.. IDlNtlflCAlU1 PE"ICOLUL,Ui

)0. Ananzl. IUueturllactivttate,(Structure .. ActivLty IRelalio.,.nip; IAR.) pe baza. Pflo:pltetilUor fizice,~ C!hi,miC8!: SOhJDiii'tate, 'staDl'I"', pH,

IlIea.ctivitate, eledrcfiUeitate, vOiati1litate. Kwa (Q8AR.); .

)0 Tests, toxicolog'[ce~ iln v!t~;. ;~ \f:vc~ -

"'-. T ........ · .. -- -G . -.' .. .:.... ~~ -, a, ft" ." 'VOltle 'g,ent::=Uce. ,n VIUOI I, ... ~1V ... ;

). Studn ,de biomaJk.ri (Biomonitonzare}; » Studii epidemiolcgJce env;ironm.enMle_

WIHO: "IUF:E liS ,A RJ:SKY BUSIN~",'"

Rflcul: IP'robIbUltltM p,roducrli unu·' (l8ln·eoll dlflnlt fdlHomfort, afact milnor. lIoIli" moarta), pe ,Q pedCNIdi 1110.' ...,.. .....

unde:

P = probanUitates';,

H:=I intendatea. efect6lor :(,ezulta,tu ex.punenl" harm)

• IGradul de nsc·:. '~1 .

• Mod de! evaluare: caz I po'pU'i!atie I an Rise relativ: J.LR :: 1/1.000.000 =1 O.06/an

(11 oaz de Imoarte pe 1.0001.000' d.e popula,.elan) Ai.sc ,coIecUv: fRpo'p = N . RI

Ex. IpopulaVa: N = 107'

R,pop :,101·· .... 10-5,:= 102 =: 1'OO/1.000 .. 000Jan

Dozi~ntan.ltate ,da .f~ ~aract • .oI .,. ,- .

_ _.v", twa II~IZ •• Z ~axlo.tlt •• ind,iviClullll

~,

,'I l' '1.1

4. (l1~ ~

FACTORI DI II I DEN I DE SUBSTANTA CDoD, : • .,ctura, ch'lm'lcll factarl'flZlco-chlmilcl)

Doza: can,litatel de, lubll'ln_" ClrI pltrunII, in organlam 'nCr-un anum'lt Interval CI,I"ti,mp Ipfiactuoe IUllnllnumlit .Iet.

• Dod eficace: ole ,(,doz. te:rlp.utice)

,e Doze "to,xi:ce: DT (ca,flct,.riUf'. 'toxicitI1ii)

Doze,! care ,~rlctlfiZ'IZI ~gxicitlt.·i _cutl':

IDLa

Dt11 DL1o, D:lso, DL1'OC (Img kg ,corp; ImignOkgl COlrp)

'ot .peda animalului, calea de, iintroducere,

.. rlspUIn8ull u'm'I,lrit, pen,Q'sda de expunero" pe,n,oad:a de observa~e" sa,ria, de doze

....... _

I'

I'

I

/.

/

9

,

,

., •

2: •

~--==~--:=:~,_,_--~-

1 ,0 ·du~ere de cap .

2" a me,ealll" glreatlJ vlr;slturil" itaxi:e 3., tdpotonie, obnubilare,

4. Ipierderea cuno,ttn~il

5. 'com,i, m,oarte

Dod d. P •. I p8'ntrUi lexpozqie de lungl du~atl (,kalzOb d6zi., thereshold d!ose')

[NO~eL .= No O:blervecl Ad",,, [Effect Levell

(dolzl media zUni.eI: firA elect - mglkg corlp)

DZA (AID'!) :: Doze Zilnicl. Acceptatl (Acceptlblll Gaily lint.lke)

A.DI-= NOAIL' 10

- FS

~OAEL = Low •• ,: O_Nla Adv _liM iftet Levil I(CaI lm.l!i JOI "'ivall de lefeet IclvflIO~bII·rvlt)

U • 90 substanta e cum,ul1ativl

AF r> 2 subltan~ e rel1atlv cumUI.tivl AF' <12 8ubatanta nu Mt. cumulativl

The

Chemical formula NOAEL 'I.OAEL (voL
(VQ~. '%) %)
CID 0 CB.3 ~O 20 -
CH3CH2,CH3 S 10 -
CH1,DCH~H3 - \5
CF3CF'2CP2CF3 .- 40 >.40
GF3CF~CF3 -- ]0 >jO
C:F3CHFCHFl 1 2,5 I 3.5
CF,3CHFCP3 () II 10.5
CF3CH2CF3 ;,0. ~5
CH2f2 10 25
CHF',3, 30 >50
CH2FC'!3, ,4 - 8
I C:H3CF3, . 4 8
1 CltF2.CF3 7.S W
-
'Cil3CF2H S 15 .
C~GIH 2.S 5
CF2Cl2' 2 . .5 :5
CfC[3 0.5
caz-ccia 2,.5 5,
CC13r'RJ 0.2,5 10.5
CF2C1CH,3, 2.5, 5
C1Cl2CHJ 0.5
CF3CP2Cl ,. 15
Cf3CC[2fI 1 2.
tfC12f:H3 - 1
CF::lC:,CF2Cl ~ 2.5
CtIF~CFC],2 - 0.5 I
0.25
CFlCmCF2CFHCI .. I 2.0 - I hydrofluorocarbons

listed,

and

,-_ ..
C.hcOIlul r.fmuia NOA:EL l,OAEt.
(vo,l. %) (\i,(jl, %)
-
CF'31 0.2 0.4
CF':aBr . 5,0' 1',S
-
CFiH1!r 2 3,,9'
CF'iB'r· . -
CFiBrCl tQ .. 5 1.0
CF'lBrCF:2Br . 0.1
CBrCIIFCBrP,2 0 .. 5
Cf'JCFtCFlI * 0.1. ~

' ...

.110. u,. iI.

- ...... - , ):

, '.

Do ••

'_,~,r" 2' .. 6~ Intlivldrttll dDJI-reslolls; ",iaHonship /Of QIi ~$S'IIr14' lub~

- ,"IQ"c~'~_q~1a ~.6 vitamin or.trac, ,"""nt. ....-._~).,'

, I

Fl,IIH44. :ramo'kincti.c (1K) 11M t~JntIMh tTDJ ~mlIll'#iiDfU lnhCI'f'ruln in1tn"t;dn ,tm4 w,,1'·11r~

lIivlJtuJ Ub'qOltIJioM. ..\,; ". . -

..... -..~ - - -

.~ ....

I

,

'\

I 1

I

"\

Curbl dozl-rAspu -

401 -

/

/

,

I

'I

C:EI'1l [01:99

'r

\ log (fOlIa "=' .

~·?ONADE ~-ib~~AMTAV: bL~ I.DE. ~~ BIZTON'!,AGI ZONtLLDL, I'DE-gj __

segment I: nu produce mOtrtllitateJ., ;

segm.ent n: aunt afecta~ ceil mal Sensibili in,divizi diin popula~e segment 11~1:, 0 ,mare 'parte ai;li1dMiU~or rAsplJ.llllld ta ,do:2el admlnllb'ate (efecte:k)xice1 lefecte mortat.)

.. IIIm,nt IV: c.il ml,i IreZi •• n,iinldiivi,zi Iunt intoxicati eegmlnt V: 1 00% dintre~indivilzi Syn,t iiMIlUdClti

, t

- I I I I

Ii '10'110 10 - tao _ -,.co _

- iD6alI (rI'IQ/iIG)

I

I S.o-

I I

3A....-~_,.

9:5t!COftfidcnH UdervaJI

oa..(Ioc)-I(I;!)

liniarizare p~in Imetoda Ipliobit: pracentul de t,etaUtate 60% Icofiespunde 'probitldui5,

- .... .-

IDENTlFIIC,AREA PERJ'COLIU~UI (HAZARD IDENTIFICAnON) (,ASSeSSIN'Q TOXI,CITV 10F ICHEMICALS) H __ rd" ,perlcol:

» ,sursl $aU act1vitate ,eu poteln,ial periculo. (de ,scc:identare, fezare I boall. moarte) in anlu,mlt. cil\culmstan~ 8~~ce;

> capacitatea ine,rentA a uneil substante chimfcej bi'ofoglc;e,. ag'ent 'fizic de a produce efecte dlunltoare' (OMS);

)- efect potential' nociv.

,)-, ,Anafi,zl structurl/actJMtate (Structulr~Activtty Refatio,nship, SAR) pe baza proIP:rietl(Uor fizi,oo ,i ohimice: solubintate" stabUitate't pHI react,ivitate, electrollicitate", vo,'atUitQt~J Kula (QSAR):

• 'Teste' to!xicologioe: in vitro, in vivo:: )- Teste geneUce:' in vitro~ En vivO;

)0, Studii de biomarker1I(Biom,anitarizare); >' :StudU epidemialogiC6 ilnlviro,nmentalle.

WH:O: .,LIIFI: ,I A "IIKY BUSINESS:"

RfS'C:ul: Pft),bablllt... procl'uc.rU unu, p8r1lc'ol deflnlt (dl.aoml'olrt, efect mlln.or, bo '11" mOine) ,. 0 PlfI,Olcl" _blln. d •• mal,nltlll

R=P·I-i

p ,= probabUitatel,;

H =: Ij'nt,ensitatea ,efectelar' (rezultatul expu'ne;ri:ij harm)

• Gradul d,e rise: '0-1

• Mbd de evaluare:' eaz I popula,i:e, I an Rise lreiati¥: tJR::: 1/1.00(1'.000 = 10'-6tan.

(1 caz de Imoarte pe 1.000.1000 de popula'ie/a.n) Rise colectliv: Rpop :: IN . R,'

lEx .. poP'lJlatt'81: N ~' 107

IRpop ':, 1107 - 10-5 = 1102 =1'001'1 .000.000/an

hbbit (DIIId1lldteil) Moue I(CO-~)I HumID

RIt (Spmpe-DIWley) Moue (swtu"

Mo_ (lCR.~'wiIs) .RIt(Wi_>

lit)1 250 602 '908

noo 1.400'" . 21.80

Stiwc',: Adaped rfOlD ATSDR (I.~.l'~ Pmftl~for ChlorofDrm ..

. --...., .s.edI onl IJdI.rt ot'doIlnl, ~!mkt.

D.J:Jtb

0a.II '90 ~ 612

Subc:rnan!I3UJ, 48, 3:

Inllam_ular 4

ln~riwnea1. 33, 1.4

. Inn:vefiOUS 10 - 1.1

IDtraoeU~11'

Dennall

420 15''00

HX) 40

..

1 10."': 'i en Ll5

U'7

~: AdIpCoCd ftaD NrwIbooI;qJ~. ~.An doIa IN In IIII1ts of~.

»a&

Stabiiliirea valorf NOAE,L

II

t

! I I I i

E.ffekt ~lnzid1enz

,experilmentell-' Werte !:vlll!rifilierbt:

'fiktiv,e Allissagen

DosiS --

( L, f ! tI· _...... .' t • .,

'Toxic I ••• lubcronlcl, cronl~ M,TD :: Cancentfa1i& Maxtm to!.rab,nl

C!ru.=: Concenntia IMaxllma Admil.

• MAJK = Maxlilmale Arblitlpl'ltz Kon.nultion,I'n

• TLV;!Il Thr .. hol~d Li,mit Valui

• concenltrliil CI. lulDltln\llli 'Ga,l'i iThJnCitOtii ,pot fi .Xp,U,il condnulu timp Cit a ore zUnl.ell anlii tml tir It .. tnuIlgl vii •. , fir. 8,

o produCl, niCi '-In ,limptOnil ,d'. 101111 (PI'nt~1.I1 m:ldiu ,c,omunlll)

mg/m3, mgII. pp,m,

• TIL.V-BTIEL.:: Thlrelhold !Limit, Value - sholt te"" ":J(lpolure 11'm Itt

• MAl< - fa,v',d expaziciO ~ , 0

Con,cenlr.". '. vi" (pl.tOn): nu pot: fi de;pltite in IliHCii un m,o,ment: PII PI fCU tI II II ZiI.:i cu.' munCi

• (TLV - ,0 .: f'LV - Gt-iling v:alueS"

• (CS~ClkonClntr.Ci,OI)

o elsse de to!xic~ate pe Ibaza, V,lliolrii C1IL!OI

.. extrem de toxice: IDLso~: 1 lmglk,g

... foarte' 'texlca 1 mgl1tgl s Dlsa s 50 mglk,g

.. maderat to~lc:e 50 mglkgl s OLeo, S 500 mQAcSJI

.. :81'ab'io,xice 500 mg/kg ~ Dl5Q S :5000 malk;i

- practi'Q neto,dce5DOO mgJt(g !S: DL.!O ~ 16000 mgtlkg

- Iipsite d,e toldcltate Dll'lll ~ 15000 mgikg -