- Inability at a cellular level to absorb glucose (inc
- weight loss despite increased appetite glucose resistance) with decrease pancreatic glucose production leads to inc fat and lipid metabolism (catabolic state) - Polyphagia - Inc Gluconeogenesis with glycogenolysis brain sees Endocrine this as fasting state
- Polyuria - Hyperglycemic state exceeds renal threshold, inc
glucosuria. Glucose causes osmotic dieresis
- Inc osmotic dieresis leads to dehydration, Inc thirst and
- Polydipsia ADH
- No depression, sleep patterns,
Psychiatric anxiety
- No verbal output x 1 week - Expressive aphasia (Broca’s Area) , difficulty of
Neurological speaking - Blurred vision - Glucose readily absorbed by the lens, cx flexibility and Eyes shape
- shortness of breath - Increase afterload due to hypertension cld lead to LVH
and thus left sided dysfunction - No exercise intolerance, PND, Cardiovascular orthopnea, edema, palpitations, faintness, loss of consciousness, claudication
- No cough, sputum, wheeze,
Respiratory hemoptysis
- No runny nose, frequent nose bleeds
(epistaxis), sinus pain, stuffy ears, Ears, Nose, Mouth, and Throat ear pain, ringing in ears (tinnitus), (ENT) gingival bleeding, toothache, sore throat, pain with swallowing (odynophagia)
- Difficulty in swallowing Gastrointestinal
Integumentary - No pruritus, rashes
- No pain, stiffness (morning vs day
Musculoskeletal long, improves/worsens with activity), joint swelling - Long standing diabetes and hypertension increases vascular permeability thus increase extracellular matrix Urinary - Edema accumulation thickens the glomerulus leads to glomerulosclerosis.