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ฉ2010 UpToDate ฎ

Water and fat soluble vitamins  

  Function Deficiency syndrome

Water-soluble

Beriberi - Congestive heart

failure (wet beriberi), aphonia,
Thiamine peripheral neuropathy,
B1, thiamine
pyrophosphate Wernicke encephalopathy (
nystagmus, opthalmoplegia,
ataxia), confusion, or coma

Nonspecific symptoms including

edema of mucus membranes,
Flavine adenine
B2, riboflavin angular stomatitis, glossitis,
dinucleotide
and seborrheic dermatitis (eg,
nose, scrotum)

Pellagra - Dermatitis on areas

exposed to sunlight; diarrhea
with vomiting, dysphagia,
Nicotinamide mouth inflammation (glossitis,
Niacin, nicotinic
adenine angular stomatitis, cheilitis);
acid
dinucleotide Headache, dementia,
peripheral neuropathy, loss of
memory, psychosis, delirium,
catatonia

Anemia, weakness, insomnia,

B6, pyroxidine, Transaminase difficulty walking, nasolabial
pyridoxal cofactor seborrheic dermatitis, cheilosis,
stomatitis

One carbon Megaloblastic anemia (

B12, cobalamin
transfer pernicious anemia)
 One carbon
Folate Megaloblastic anemia
transfer

Nonspecific symptoms including

Pyruvate
altered mental status, myalgia,
Biotin carboxlase
dysesthesias, anorexia,
cofactor
maculosquamous dermatitis

Nonspecific symptoms including

paresthesias, dysesthesias ("
Pantothenate Coenzyme A
burning feet"), anemia,
gastrointestinal symptoms

Scurvy - fatigue, petechiae,

Antioxidant,
ecchymoses, bleeding gums,
C ascorbate collagen
depression, dry skin, impaired
synthesis
wound healing

Fat-soluble

Vision, Night blindness, xerophthalmia,

A epithelial keratomalacia, Bitot's spot,
differentiation follicular hyperkeratosis
Retinol    

Retinal    

Retinoic acid    

Prohormone for
Rickets, osteomalacia,
D calcium
craniotabes, rachitic rosary
regulation
Cholecalciferol    

Ergocalciferol    

Sensory and motor neuropathy,

E Antioxidant ataxia, retinal degeneration,
hemolytic anemia
Tocopherols    

Clotting factors,
K Hemorrhagic disease
bone proteins

Phylloquinone    
 Menaquinone    

Menadione    

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